Faculty Associates

James C. Fleet

Contact Information
Email: fleet |at| purdue.edu
Office: STON G-1D Map
Phone: (765) 494-0302
Fax: (765) 494-0906
Homepage: Homepage
Distinguished Professor of Nutrition Science

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Education


B.S. Cornell University Animal Science 1981
M.S. University of Delaware Animal Nutrition 1984
Ph.D. Cornell University Nutritional Biochemistry 1988

Research Interests


Vitamin D, impact on calcium metabolism, prostate cancer, Regulation of mineral metabolism, Intestinal biology, Impact of aging on biological function

Teaching Interests


Presentation skills for Graduate students (FN695) Nutritional Biochemistry and Physiology I (FN590B) Nutrition and Genetics (FN special topics course)

Grants


National Institutes of Health
US Veterans Administration
US Department of Agriculture
Private industry and foundations

Publications


Yin, L., Unger, E.L., Jellen, L.C., Earley, C.J., Allen, R.P., Tomaszequicz, A., Fleet, J.C., and Jones, B.C. (2012) Systems genetic analysis of multivariate response to iron deficiency in mice. Am. J. Physiol. 302:R1282-1296.

Cui, M. and Fleet, J.C. (2012) Villin-promoter mediated transgenic of TRPV6 increases intestinal calcium absorption in wild-type and VDR knockout mice. J. Bone Min. Res. 27:2097-2107.

Jiang, Y. and Fleet, J.C. (2012) Effect of phorbol 12-myristate 13-acetate activated signaling pathways on 1a,25 dihydroxyvitamin D3 (1,25(OH)2D3) regulated 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1) gene expression in Caco-2 cells. J. Cell. Biochem. 113:1599-1607.

Jiang, Y., Cui, M., and Fleet, J.C. (2012) Phorbol esters enhance 1a,25(OH)2D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (SP3) in Caco-2-cells. Mol. Cell Endocrinol. 361:31-39.

Farrow, E.G., Yu, X., Summers, L.J., Davis, S.I., Fleet, J.C., Allen, M.R., Robling, A.G., Stayrook, K.R., Jideonwon, V., Magers, M.J., Garringer, H.J., Vidal, R., Chan, R.J., Goodwin, C.B., Hui, S., Peacock, M., and White, K.E. (2011) Altered FGF23 proteolytic regulation causes late-onset hypophosphatemia during iron deficiency in an ADHR mouse model. Proc. Natl. Acad. Sci. USA. 108:E1146-1155.

Kovalenko, P.L., Zhang, Z., Yu, J.G., Clinton, S.K., and Fleet, J.C. (2011) Disrupting vitamin D (VD) signaling increases androgen dependent proliferation and reduces apoptosis in mouse prostate. Cancer Prevention Research.

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