Project Ultrasound-Based Quantification of Intervertebral Disc Strain Under Dynamic Loading Using Texture-Correlation Program DUIRI - Discovery Undergraduate Interdisciplinary Research Internship Term Fall 2023 Status Accepted Research Area Biomedical Engineering, Health and Kinesiology Description Herniated discs in the spine pose a significant burden on patients due to their high prevalence, association with lower back and leg pain, and impact on daily activities and quality of life. However, the underlying mechanical factors contributing to intervertebral disc (IVD) failure remain poorly understood, despite the common occurrence of herniated discs. Therefore, there is a need to better understand the mechanical behavior of IVDs as they relate to herniation and ultimately develop accessible and cost-effective diagnostic methods to assess disease progression. In this study, we aim to integrate high-resolution ultrasound imaging and texture correlation analysis to quantify strain profiles in IVDs during dynamic loading conditions with a custom-built mechanical tester. We will acquire B-mode ultrasound images of the bovine caudal spine and quantify IVD strain using direct deformation estimation (DDE) in MATLAB. Our focus will be on evaluating axial IVD strain under different loading conditions. By analyzing these findings, we aim to enhance non-invasive image-based assessment of IVD herniation and contribute to our understanding of IVD strain patterns under dynamic loading. Supervisor Craig J Goergen Mentor Chad C Carroll Type of work required The intern will work directly with ultrasound imaging and spend time performing DDE analysis. The intern will dissect and prepare IVD samples, collect images during mechanical testing, and analyze the images at varying loading conditions. The specifics of sample preparation and image collection will be taught on site. Websites Qualifications Experience in coding (MATLAB, Python) or previous research experience is strongly preferred. Applicant should possess a strong drive and initiative. GPA of 3.0 or above is desired. A basic understanding of biomechanics is recommended. Credit Hours 3 Weekly Hours 10 (estimated)