ABE 680 - Bioseparations and Bioprocess Engineering: Principles, Practice and Economics
Instructors: Abigail Engelberth and Michael Ladisch
The course covers the modeling, design and engineering analysis of bioseparations processes on macro- and micro-scales, and the bio-processing and characterization of therapeutic properties of biomolecules and biomaterials that affect their fractionation. Fundamental and quantitative analyses of these processes are illustrated by examples of separations of biomolecules derived from pharmaceutical, food, bioproducts, and biofuel industries. Examples and case studies of molecules derived from recombinant organisms include therapeutic proteins and peptides, antibiotics, sugars, and amino acids (for food uses). The application of bioseparation principles to micro-biosensing systems (biochips) for detection of microbial pathogens and proteins are also addressed.
Teach advanced methods for bioseparations that combine engineering fundamentals and biological principles for:
1. Developing purification methods for therapeutic biomolecules and other bioproducts derived from recombinant and wild type organisms, transgenic animals or agriculturally derived materials.
2. Developing purification methods for therapeutic biomolecules and other bioproducts derived from recombinant and wild type organisms, transgenic animals or agriculturally derived materials.
3. Analyzing, modeling, and designing bioseparation processes for purification of biological products by
- liquid chromatography and affinity separations;
- membrane systems (microfiltration, ultrafiltration, dialysis);
- centrifugation and filtration;
- precipitation and crystallization
Typically offered every other Fall semester.
3.0 credit hours