Margaret (Peg) Miller, DVM, PhD

Professor of Veterinary Pathology

Department of Comparative Pathobiology /
Animal Disease Diagnostic Laboratory

Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

Phone: 765.494.7456
Email: pegmiller@purdue.edu

Education

1981 - PhD | Washington State University
1977 - DVM | University of Missouri

Certification

Diplomate: American College of Veterinary Pathologists

Selected Publications

– 1. Cantor GH, Caswell JL, Crissman JW, Gillette DM, Gunson DE, HogenEsch H, Kiupel M, Mense MG, Miller MA, Rush LJ, St. Leger JA, Schoeb TR, Sellers RS, Sills RC, Swayne DE, Thomas HC, Ward JM, Alden CL: Veterinary Pathology and peer review. Editorial. Vet Pathol 2009 46: 173-175

– 2. Bangari DS, Miller MA, Stevenson GW, Thacker HL, Sharma A, Mittal SK: Cutaneous and systemic poxviral disease in red (Tamiasciurus hudsonicus) and gray (Sciurus carolinensis) squirrels. Vet Pathol 46:667-672, 2009

– 3. Webster JD, Miller MA, Dusold D, Ramos-Vara J: Effects of Prolonged Formalin-fixation on Diagnostic Immunohistochemistry in Domestic Animals. J Histochem Cytochem 57:753-761, 2009

– 4. Ramos-Vara JA, Miller MA: Immunohistochemical evaluation of GATA-4 in canine testicular tumors. Vet Pathol 46:893-896, 2009

– 5. Webster JD, Horstman LA, Miller MA: Pathology in practice. Severe multifocal to locally extensive, monophasic skeletal muscle necrosis and multifocal, monophasic myocardial necrosis. J Am Vet Med Assoc 235:827-829, 2009

– 6. Mouser P, Miller MA, Antuofermo E, Badve SS, Mohammed SI: Prevalence and classification of spontaneous mammary intraepithelial lesions in dogs without clinical mammary disease. Vet Pathol 2010; 47(2):275-284

– 7. Reed LT, Balag KA, Boes KM, Messick JB, Miller MA: Pathology in Practice. Granulomatous pneumonia and prostatitis in a German shorthaired pointer with blastomycosis. J Am Vet Med Assoc 236(4):411-413, 2010

– 8. Webster JD, Miller MA, DuSold D, Ramos-Vara J: Effects of prolonged formalin fixation on the immunohistochemical detection of infectious agents in formalin-fixed, paraffin-embedded tissues. Vet Pathol 2010;47(3):529-535

– 9. Alkabes KC, Hawkins JF, Miller MA, Nauman E, Widmer W, Dunco D, Kras J, Couetil L, Lescun T, Gautam R. Evaluation of the effects of transendoscopic diode laser palatoplasty on clinical, histologic, magnetic resonance imaging, and biomechanical findings in horses. Am J Vet Res 2010;75(5):575-582.

– 10. Ramos JA, Miller MA, Gilbreath E, Patterson JS. Immunohistochemical Detection of CD34, E-cadherin, Claudin-1, Glucose Transporter 1, Laminin, and Protein Gene Product 9.5 in 28 Canine and 8 Feline Meningiomas. Vet Pathol 2010;47(4):725-737.

– 11. Bevier DE, Miller MA, Rohleder JJ, Wozniak AD. Pathology in Practice: Superficial necrolytic dermatitis. J Am Vet Med Assoc 2010; 237(4):365-367.

– 12. Reed LT, Miller MA, Visvesvara GS, Gardiner CH, Logan MA, and Packer RA. Diagnostic Exercise: Cerebral Mass in a Puppy with Respiratory Distress and Progressive Neurologic Signs. Vet Pathol 2010;47(6): 1116-1119.

– 13. Frank CB, Hammer JD, Miller MA. Pathology in Practice: Perineal squamous cell carcinoma in a mare. J Am Vet Med Assoc 2010; 237(6):637-639.

– 14. Munson L, Craig LE, Miller MA, Kock ND, Simpson RM, Wellman ML, Sharkey LC, Birkebak TA. Elements of good training in anatomic pathology. Vet Pathol 2010; 47(5):995-1002.

– 15. Burrai GP, Mohammed SI, Miller MA, Marras V, Pirino S, Addis MF, Uzzau S, Antuofermo E. Spontaneous feline mammary intraepithelial lesions as a model for human estrogen receptor and progesterone receptor-negative breast lesions. BMC Cancer 2010;10:156-166.

– 16. Packer RA, Freeman LJ, Miller MA, Fauber AE, M orrison WB. Evaluation of minimally-invasive brain biopsy and intracranial brachytherapy catheter placement in dogs. Am J Vet Res 2011;72:109-121

– 17. Ramos JA, Miller MA. Immunohistochemical identification of canine melanocytic neoplasms with antibodies to melanocytic antigen PNL2 and tyrosinase: comparison with Melan A. Vet Pathol 2011;48:443-450. doi:10.1177/0300985810382095.

– 18. Valli VE, San Myint M, Barthel A, Bienzle D, Caswell J, Colbatsky F, Durham A, Ehrhart EJ, Johnson Y, Jones C, Kiupel M, LaBelle P, Lester S, Miller M, Moore P, Moroff S, Roccabianca P, Ramos-Vara J, Ross A, Scasi T, Tvedten H, Vernau W. Classification of Canine Malignant Lymphomas According to the World Health Organization Criteria. Vet Pathol 2011;48:198-211.

– 19. Kiupel M, Webster JD, Bailey KL, et al. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol 2011;48:147-155.

– 20. Kamstock DA, Ehrhart EJ, Getzy DM, et al. Recommended guidelines for submission, trimming, margin evaluation, and reporting of tumor biopsy specimens in veterinary surgical pathology. Vet Pathol 2011;48:19-31.

– 21. Corriveau L, Bevier D, Miller MA. Pathology in Practice (Post-rabies vaccination panniculitis in a dog). J Am Vet Med Assoc 2011;238(9):1115-1117.

– 22. Dalesandro N, Stiles J, Miller M. Septic lens implantation syndrome in a cat. Vet Ophthalmol 2011;14(S1):84-87. DOI:10.1111/j.1463-5224.2011.00882.

– 23. Miller MA, Mohammed SI. In pursuit of a prognostic marker in canine mammary tumors. Guest editorial in The Vet J 2011; 189:245. First published online 02Feb2011 as doi:10.1016/j.tvjl.2010.12.005

– 24. Ramos-Vara JA, Miller MA. Immunohistochemical expression of E-cadherin does not distinguish canine cutaneous histiocytoma from other canine round cell tumors. Vet Pathol. 2011 May;48(3):758-763. doi:10.1177/0300985811398251

– 25. Meyerholtz KA, Burcham GN, Miller MA, Wilson CR, Hooser SB, Lee ST. Development of a Gas Chromatography/Mass Spectrometry Technique to Diagnose White Snakeroot (Ageratina altissima) Poisoning in a Cow. J Vet Diagn Invest 2011; 23(4):775-779. DOI: 10.1177/1040638711407899

– 26. Cordero M, McFarlane D, Breshears MA, Miller LM, Miller MA, Duckett WM. The effect of season on the histologic and histomorphometric appearance of the equine pituitary gland. J Eq Vet Sci 2012; 32(2):75-79 DOI: 10.1016/j.jevs.2011.01.003

– 27. Burcham GN, Miller MA, Hickok T. Pathology in Practice—CANV mycotic dermatitis and cellulitis in a Bahama anole. J Am Vet Med Assoc 2011 Nov 15;239(10):1305-1307.

– 28. Sharkey LC, Simpson RM, Wellman ML, Craig LE, Birkebak TA, Kock ND, Miller MA, Harris RK, Munson L. The value of biomedical research training for veterinary anatomic and clinical pathologists. Veterinary Pathology 2012;49(4):581-585. doi:10.1177/0300985811420583

– 29. Jennings RN, Miller MA, Ramos-Vara JA. Comparison of CD34, CD31 and factor VIII-related antigen immunohistochemical expression in feline vascular tumors and CD34 expression in feline nonvascular tumors. Vet Pathol 2012;49(3):532-537.

– 30. Reed LT, Knapp DW, Miller MA. Cutaneous metastasis of transitional cell carcinoma in 12 dogs. Vet Pathol 2013; 50:676-681.

– 31. Frank CB, Valentin SY, Scott-Moncrieff JC, Miller MA. Correlation of inflammation with adrenocortical atrophy in canine adrenalitis. J Comp Pathol 2013;149:268-279.

– 32. Ruth JD, Heng HG, Miller MA, Constable PD. Effect of anisotropy and spatial compound imaging on renal cortical echogenicity in dogs. Accepted by Vet Radiol Ultrasound May 2013.

– 33. Bentley RT, Ober CP, Anderson KL, Feeney DA, Naughton JF, Ohlfest JR, O’Sullivan MG, Miller MA, Constable PD, Pluhar GE. Canine intracranial gliomas: Relationship between magnetic resonance imaging criteria and tumor type and grade. Vet J 2013; 198:463-471.

– 34. Charney VA, Toth B, Couëtil L, Miller MA. Pathology in Practice: Ichthyosis in an alpaca. J Am Vet Med Assoc 2013; 243:1701-1703.

– 35. Peña L, Gama A, Goldschmidt MH, Abadie J, Benazzi C, Castagnaro M, Díez L, Gärtner F, Hellmén E, Kiupel M, Millán Y, Miller MA, Nguyen F, Poli A, Sarli G, Zappulli V, Martín de las Mulas J. Canine mammary tumors: a review and consensus of standard guidelines on epithelial and myoepithelial phenotype markers, HER2, and hormone receptor assessment using immunohistochemistry. Vet Pathol 2014;51:127-145.

– 36. Ramos-Vara JA, Webster JD, DuSold D, Miller MA. Immunohistochemical evaluation of the effects of paraffin section storage on biomarker stability. Vet Pathol 2014;51:102-109.

– 37. Ramos-Vara JA, Miller MA. When tissue antigens and antibodies get along: revisiting the technical aspects of immunohistochemistry—the red, brown and blue technique. Vet Pathol 2014; 51:42-87.

– 38. Ramos-Vara JA, Frank CB, Dusold D, Miller MA. Immunohistochemical expression of melanocytic antigen PNL2, Melan A, S100, and PGP 9.5 in equine melanocytic neoplasms. Vet Pathol 2014; 51:161-166.

– 39. Childress MO, Dhawan D, Leamon CP, Miller MA, Ramos-Vara JA, Naughton JF, Low PS, Knapp DW. Assessment of folate receptor expression and folate uptake in multicentric lymphomas in dogs. Am J Vet Res 2014;75:187-194.

– 40. Charney VA, Bertin FR, Krtichevsky J, Miller MA. Pathology in practice: Myometrial leiomyoma in a Vietnamese potbellied pig. J Am Vet Med Assoc 2014; 244:541-543.

– 41. Hawkins JF, Couëtil L, Miller MA. Maintenance of arytenoid abduction following carbon dioxide laser debridement of the articular cartilage and joint capsule of the cricoarytenoid joint combined with prosthetic laryngoplasty in horses: an in vivo and in vitro study. Vet J 2014;199:275-280.

– 42. Taylor SD, Toth B, Baseler LJ, Charney Va, Miller MA. Lack of correlation between papillomaviral DNA in surgical margins and recurrence of equine sarcoids. J Eq Vet Sci 2014;34:722-725.

– 43. Toth B, Bertin FR, Miller MA, Charney VA, Kritchevsky JE. Evaluation of a technique for percutaneous endoscopic gastrostomy tube placement in horses. Am J Vet Res 2014;75:354-360.

– 44. Twitchell E, Hartman RA, Waxman SJ, Lescun TB, Miller MA. Pathology in Practice (coronary band dystrophy in a horse). J Am Vet Med Assoc 2014;245:385-387.

– 45. Bentley RT, Burcham GN, Heng HG, Levine JM, Longshore R, Carrera-Justiz S, Cameron S, Kopf K, Miller MA. A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes. Vet Comp Oncol. 2014; doi: 10.1111/vco.12106

– 46. Miller MA, Moore GE, Bertin FR, Kritchevsky JE. What’s new in old horses? Postmortem diagnoses in mature and aged equids. Vet Pathol 2016;53(2):390-398

– 47. Heng HG, Lim CK, Miller MA, Broman MM. Prevalence and significance of an ultrasonographic colonic muscularis hyperechoic band paralleling the serosal layer in dogs. Vet Radiol Ultrasound 2015;56(6):666-669.

– 48. Broman MM, Miller MA. Pathology in practice: feline thymic lymphoma. J Am Vet Med Assoc 2016;248(4):381-383.

– 49. Ruff CF, Lim CK, Ramos-Vara JA, Custead MR, Parys MM, Poulson JM, Miller MA. Imaging diagnosis—nuclear scintigraphic, radiological, and pathologic characteristics of metastatic pilomatricoma in a dog. Vet Radiol Ultrasound 2016;57(6):E58-E62.

– 50. Ramos-Vara JA, Frank CB, DuSold D, Miller MA. Pax8 and Napsin-A immunohistochemical detection in canine thyroid tumors: comparison with thyroglobulin, calcitonin and thyroid transcription factor-1. J Comp Pathol. 2016;155(4):286-298. http://dx.doi.org/10.1016/j.jcpa.2016.07.009

– 51. Gillespie Harmon CC, Hawkins JF, Jianming L, Connell S, Miller M, Saenger M, Freeman LJ. Effects of topical application of silver sulfadiazine, triple antibiotic (neomycin, polymyxin, bacitracin), or hyperosmolar nanoemulsion on wound healing, bacterial load, and granulation tissue formation in bandaged full-thickness equine skin wounds: a randomized controlled study. Am J Vet Res 2017; 78(5):638-646.

– 52. Charney VA, Miller MA, Heng HG, Weng HY, Knapp DW. Skeletal metastasis of canine urothelial carcinoma: Pathologic and computed tomographic features. Vet Pathol 2017;54(3):380-386. doi:10.1177/0300985816677152

– 53. Vigeral M, Bentley RT, Rancilio NJ, Miller MA, Heng HG. Imaging diagnosis—antemortem detection of oligodendroglioma ‘cerebrospinal fluid drop metastases’ in a dog by serial magnetic resonance imaging. Vet Radiol Ultrasound, 2017 Feb 7. doi: 10.1111/vru.12474. [Epub ahead of print]

– 54. Peat TJ, Edmondson E, Miller MA, DuSold DM, Ramos-Vara JA. Pax8, Napsin A and CD10 as immunohistochemical markers of canine renal cell carcinoma. Vet Pathol 2017 Jan 1:300985817698211. doi: 10.1177/0300985817698211. [Epub ahead of print]

– 55. Beck J, Miller MA, Frank CB, DuSold DM, Ramos-Vara JA. Surfactant Protein A and Napsin A in the immunohistochemical characterization of canine pulmonary carcinomas: comparison with Thyroid Transcription Factor-1. Vet Pathol. 2017; 54(5):767-774. doi:10.1177/0300985817712559

– 56. Moore BA, Duffy DJ, Heng HG, Lim CK, Miller MA. What’s your diagnosis? Canine proliferative villonodular synovitis and cranial cruciate disease. J Am Vet Med Assoc. 2017;251(11):1241-1243

– 57. Ramos-Vara JA, Edmondson EF, Miller MA, DuSold DM. Immunohistochemical profile of 20 feline renal cell carcinomas. J Comp Pathol 2017;157:115-125.

– 58. Vilaplana-Grosso F, Tinkler S, Sola M, Miller M, Heng HG. Radiographic and computed tomographic appearance of caseous lymphadenitis in a goat. Vet Radiol Ultrasound, accepted 27 October 2017.

– 59. Peat TJ, Miller MA. Pathology in Practice: Mulberry heart disease in a two-month-old crossbred gilt. J Am Vet Med Assoc 2018;253(6):719-721.

– 60. Schafbuch RM, Hermida JA, Hammac GK, Kritchevsky JE, Miller MA. Pathology in practice: Thrombotic meningoencephalitis in a yearling bull. J Am Vet Med Assoc. 2018;253(11):1417-1419.

– 61. Ramos-Vara JA, Miller MA, DuSold D. Immunohistochemical expression of CD31 (PECAM-1) in non-endothelial tumors of dogs. Vet Pathol 2018;55(3):402-408.

– 62. Filley A, Henriquez M, Bhowmik T, Tewari BN, Rao X, Wan J, Miller MA, Liu Y, Bentley RT, Dey M. Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas. J Neurooncol 2018; 137(3):469-479.

– 63. Heng HG, Lim CK, Steinbach S, Broman MM, Miller MA. Clinical and histopathologic findings in dogs with the ultrasonographic appearance of gastric muscularis unorganized hyperechoic striations. Acta Vet Scand. 2018;60:11-17.

– 64. Bentley RT, Thomovsky SA, Miller MA, Knapp DW, Cohen-Gadol AA. Canine (pet dog) tumor microsurgery and intratumoral concentration and safety of metronomic chlorambucil for spontaneous glioma: A phase I clinical trial. World Neurosurgery 2018; Aug;116:e534-e542.

– 65. Miller MA, Bruyette DS, Scott-Moncrieff JC, Owen TJ, Ramos-Vara JA, Weng HY, Vanderpool AL, Chen AV, Martin LG, DuSold DM, Jahan S. Histopathologic findings in canine pituitary glands. Vet Pathol. 2018;55(6):871-879.

– 66. Miller MA, Owen TJ, Bruyette DS, Scott-Moncrief JC, Ramos-Vara JA, Weng HY, Chen AV, Martin LG, DuSold DM. Immunohistochemical evaluation of canine pituitary adenomas obtained by transsphenoidal hypophysectomy. Vet Pathol. 2018;55(6):889-895.

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