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SpectraCode Announces Quantitative Analysis of Tablet Film Coating by Means of Raman SpectroscopyWest Lafayette, IN, December 16, 2005 — SpectraCode, a maker of high-performance fiber optically-coupled microscope probe heads, announces a new approach to eliminate non-uniform coating distribution over a pharmaceutical tablet surface by using a distributive multi-point focus Raman probe.
The probe is used to characterize the average coating thicknesses and coating distribution irregularities in a tablet. Coating prediction models correlate average Raman spectra of different tablet sets with respective coating times. Raman spectra is acquired in one second or less using a high-power laser with a distributive-focus probe, which integrates over a circular region on the tablet to increase sampling area and substantially reduce the effect of coating non-uniformity. This development work was done at Purdue University. The technology fits well with the goals of Process Analytical Technology (PAT), to conduct key in-line or at-line measurements, to obtain vital information faster. SpectraCode holds a patent for this technology along with three other patents, including one for a Raman system for rapid sample identification, one for a portable spectral imaging microscope system (PRIM), and one for a confocal microscope system. FOR MORE INFORMATION: CAPTION: |
