Project C3: Shared Imaging Measurement Systems
Project C3 aims to develop shared measurement systems and protocols, including high-resolution imaging and atomic force microscopy (AFM).
Research Outputs
Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging
Dendritic nonlinearities enable "barcoding" through spike timing/firing rate control; sodium spikes crucial for pattern classification.
Figure 16. Multiplexing in basal dendrites of L5 PNs. A) Holographic two-photon uncaging. B) Precision and gain control by multibranch synaptic inputs. C) Barcoding of spatial-temporal input patterns in output spike trains.
Xiao, S., et al. 2024. Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging. Cell Reports, 43(7).