Project C1: Shared-resource simulation tools
Project C1 aims to develop a shared-resource platform hosting simulation tools for various scales (intracellular signaling to multicellular organization) and multi-modal biological cues.
Research Outputs
Digital cousins: Simultaneous optimization of one model for BMP signaling
Single core model captures BMP pathway in both Drosophila and zebrafish; small parameter changes explain differences.
Figure 9. Using multi-objective optimization, we calibrated a single core model to fit experimental data from both Drosophila and zebrafish.
Li, L., et al. 2025. Digital cousins: Simultaneous optimization of one model for BMP signaling. bioRxiv, 2025.02.25.640248v1.