{"id":6166,"date":"2022-11-21T19:47:00","date_gmt":"2022-11-21T19:47:00","guid":{"rendered":"https:\/\/new.www.purdue.edu\/newsroom\/?p=6166"},"modified":"2024-07-18T19:50:29","modified_gmt":"2024-07-18T19:50:29","slug":"mans-best-friend-leads-the-way-to-early-cancer-detection","status":"publish","type":"post","link":"https:\/\/www.purdue.edu\/newsroom\/2022\/Q4\/mans-best-friend-leads-the-way-to-early-cancer-detection","title":{"rendered":"Man\u2019s best friend leads the way to early cancer detection"},"content":{"rendered":"

WEST LAFAYETTE, Ind. —<\/p> \n

Cancer strikes without warning. Genetics can explain some of it, as well as environmental and lifestyle conditions. But there is no surefire way to predict who will develop cancer. That tragedy holds true for both humans and their closest domestic companions: dogs.<\/p>\n<\/div>\n\n\n

A canine cancer scientist at Purdue University<\/a>\u2019s College of Veterinary Medicine<\/a> is working to take the first steps to make a serious form of cancer in dogs \u2014 one with analogues to human health \u2014 easier to detect and treat before it has become more advanced<\/a>.  <\/p>\n\n\n\n

Scottish terriers, famous for being presidential pets to presidents George W. Bush and Franklin D. Roosevelt, \u201cJock\u201d in Disney\u2019s \u201cLady and the Tramp,\u201d and the cutest Monopoly game token, are also famous for a less cheerful reason: They get bladder cancer at rates 20 times that of other dog breeds<\/a>. And when Scotties and other dogs develop bladder cancer, it is often an aggressive form similar to muscle invasive bladder cancer in humans.<\/p>\n\n\n\n

That dog-human linkage is part of why Deborah Knapp<\/a>, Purdue Distinguished Professor of Comparative Oncology, has studied bladder cancer in canines for three decades. Knapp is the Dolores L. McCall Professor of Comparative Oncology, director of the Purdue Comparative Oncology Program<\/a> and a co-program leader in the Purdue Institute for Cancer Research<\/a>.<\/p>\n\n\n\n

\u201cFor many types of cancer in dogs or in humans, the cancer is diagnosed \u2018late\u2019 when it is already progressing and causing harm. The early stages of cancer, such as bladder cancer, may not produce any symptoms, and, therefore, the cancer goes unnoticed. And when symptoms do develop, they resemble those of a urinary tract infection, often prompting treatment with antibiotics for a while,\u201d Knapp said. \u201cWhen it becomes apparent that something more is going on and we see the dogs in the oncology clinic, the cancer has often become pretty extensive within and beyond the bladder. And it has changed so much on a molecular level that drug resistance is common.\u201d  <\/p>\n\n\n\n

Other than a few cancers physicians can and do screen for in humans \u2014 using things like mammograms, colonoscopies and PSA screening \u2014 most cancers are found only after they are well established. And in veterinary medicine, it\u2019s even worse because screening programs have not yet been developed.<\/p>\n\n\n\n

Knapp and her team followed a group of 120 Scottish terriers for three years, performing urinary tract ultrasound exams and urinalyses every six months. When those tests raised suspicion for cancer, the team performed cystoscopic biopsies.  Thirty-two of those 120 dogs turned out to have early-stage bladder cancer. The screening caught the cancer before symptoms began to emerge and before the dogs\u2019 behavior and health changed. Knapp\u2019s team also assessed the accuracy of two types of commercially available urine tests for bladder cancer screening but found that those tests did not accurately predict or identify cancer.  <\/p>\n\n\n\n

That early detection gave Knapp\u2019s team the ability to treat the cancer early and to study the way the cancer and tumors changed and developed at a molecular level as the cancer stages progressed. The dogs diagnosed with cancer were treated with deracoxib, a nonsteroidal anti-inflammatory drug (NSAID) that has antitumor activity in dogs and is typically used to treat bladder cancer in dogs. Usually, the drug results in a remission rate of 20% in dogs with the more typically advanced symptomatic bladder cancer. However, with the early detection from Knapp\u2019s team, the drug resulted in a 42% remission rate.<\/p>\n\n\n\n

\u201cFinding the cancer early in these dogs, who were behaving normally but walking around and brewing cancer in their bladders, meant we were able to treat them earlier in the cancer development process,\u201d Knapp said. \u201cThe drugs worked so much better because we started managing the cancer earlier. We expected the remission rate to be better than the \u2018usual\u2019 20%, but we didn\u2019t expect to see quite this dramatic a difference. The drug we used, Deramaxx, is considered a conservative, oral, affordable therapy. And it doubled the remission rate in the dogs, thanks to the early detection.\u201d<\/p>\n\n\n\n

Scottish terriers\u2019 high genetic predisposition to bladder cancer means they make an excellent population in which to study early cancer detection, which also means veterinarians can do the most good and save the most lives and heartaches. <\/p>\n\n\n\n

Owners of Scottish terriers know the risks going in. Scotties are prone to bladder cancer, as labs are prone to hip dysplasia and dachshunds are prone to spinal injuries. However, humans\u2019 dedication to their dogs is what made the study happen. The Scottie community supported the study, and people drove dogs hundreds of miles to participate in the trial, showing how meaningful early cancer detection is for them and highlighting how much hope people hold for early cancer screening in both dogs and people.<\/p>\n\n\n\n

\u201cFrom the veterinary perspective, our study shows that we ought to be screening dogs for bladder cancer,\u201d Knapp said. \u201cThis should become more routine for certain dogs in the future. But from the science side, we found so much more than that, especially in comparative genomics. Our study is the first to show that if you can truly find cancer early, and treat it, it makes a huge difference. Ours is the first, but we hope this will start a paradigm shift. We are moving toward a more personalized, proactive approach to addressing cancer.\u201d <\/p>\n\n\n\n

PAPER<\/strong><\/h2>\n\n\n\n

Identification of a naturally occurring canine model for early detection and intervention research in high grade urothelial carcinoma<\/p>\n\n\n\n

Frontiers in Oncology<\/p>\n\n\n\n

doi.org\/10.3389\/fonc.2022.1011969<\/a><\/p>\n\n\n\n

The abstract and author list are available online.<\/a><\/p>\n\n\n

\n
\n
\n

\n Writer\/Media contact:<\/strong>\u00a0Brittany Steff,\u00a0bsteff@purdue.edu<\/a>\u00a0
Source:<\/strong>\u00a0Deborah Knapp,\u00a0knappd@purdue.edu<\/a>\u00a0
<\/p>\n <\/div>\n

\n
\n

Note to journalists:<\/p>\n

\n A video of Knapp discussing her research is\u00a0available<\/strong><\/a>\u00a0to all AP Video Hub subscribers. <\/p>\n <\/div>\n <\/div>\n <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

WEST LAFAYETTE, Ind. — Cancer strikes without warning. Genetics can explain some of it, as well as environmental and lifestyle conditions. But there is no surefire way to predict who will develop cancer. That tragedy holds true for both humans<\/p>\n","protected":false},"author":2,"featured_media":6167,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[54,7],"tags":[],"department":[58,57],"source":[29],"purdue_today_topic":[66],"coauthors":[77],"class_list":["post-6166","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","category-research-excellence","department-purdue-moves","department-veterinary-medicine","source-purdue-news","purdue_today_topic-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/6166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/comments?post=6166"}],"version-history":[{"count":1,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/6166\/revisions"}],"predecessor-version":[{"id":6168,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/6166\/revisions\/6168"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/media\/6167"}],"wp:attachment":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/media?parent=6166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/categories?post=6166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/tags?post=6166"},{"taxonomy":"department","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/department?post=6166"},{"taxonomy":"source","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/source?post=6166"},{"taxonomy":"purdue_today_topic","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/purdue_today_topic?post=6166"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/coauthors?post=6166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}