{"id":4700,"date":"2024-01-18T18:42:00","date_gmt":"2024-01-18T18:42:00","guid":{"rendered":"https:\/\/new.www.purdue.edu\/newsroom\/?p=4700"},"modified":"2024-08-20T12:30:33","modified_gmt":"2024-08-20T16:30:33","slug":"treating-diseases-by-eliminating-protein-aggregation-in-the-brain-pancreas","status":"publish","type":"post","link":"https:\/\/www.purdue.edu\/newsroom\/2024\/Q1\/treating-diseases-by-eliminating-protein-aggregation-in-the-brain-pancreas","title":{"rendered":"Treating diseases by eliminating protein aggregation in the brain, pancreas"},"content":{"rendered":"

WEST LAFAYETTE, Ind. —<\/p> \n

Purdue University researchers have taken the first steps to treat Alzheimer\u2019s disease, Parkinson\u2019s disease and Type 2 diabetes by creating multiple patent-pending compounds shown to inhibit protein aggregation associated with those diseases.<\/p>\n<\/div>\n\n\n

According to the Centers for Disease Control and Prevention, as many as 95% of the approximately 38 million Americans with diabetes have Type 2 diabetes<\/a> and as many as 5.8 million Americans were living with Alzheimer\u2019s in 2020<\/a>. The Parkinson\u2019s Foundation reports nearly 1 million Americans are living with Parkinson\u2019s<\/a>.<\/p>\n\n\n\n

Jessica Sonia Fortin<\/a> is an assistant professor of basic medical sciences, physiology and pharmacology in the College of Veterinary Medicine<\/a> and a member of the Purdue Institute for Drug Discovery<\/a>. She leads a team working on the preparation of new small-molecule compounds and their validation through in vitro studies to inhibit the aggregation of several proteins.<\/p>\n\n\n\n

Fortin has received funding from the EveryCat Health Foundation; the Pharmaceutical Research and Manufacturers of America; and the National Institute on Aging, a division of the National Institutes of Health, to conduct the research.<\/p>\n\n\n\n

The role of protein aggregation in disease\u00a0<\/h2>\n\n\n\n

Alzheimer\u2019s and Parkinson\u2019s are the two most common neurological diseases. Symptoms include cognitive decline, movement disorders and premature death. Type 2 diabetes is an endocrinal disease that can lead to circulatory, nervous and immune system disorders.<\/p>\n\n\n\n

The development of these diseases has a common trait: the aggregation of proteins, including certain hormones.<\/p>\n\n\n\n

\u201cIn Type 2 diabetes, about 70% of cases involve a hormone called islet amyloid polypeptide, or IAPP, that accumulates in the pancreas,\u201d Fortin said. \u201cAlzheimer\u2019s disease and Parkinson\u2019s disease are associated with clumps accumulating in specific regions of the brain caused by proteins called tau and alpha-synuclein, respectively. Some forms of dementia are characterized by the presence of both tau and alpha-synuclein aggregated in the brain. There is also an interconnection between Type 2 diabetes and neurodegenerative diseases: Recent studies have found more than one aggregated protein in the pancreas and brain, indicative of the so-called \u2018cross-seeding\u2019 effects of these misshapen proteins.\u201d<\/p>\n\n\n\n

Fortin said current methods to treat these diseases focus on alleviating symptoms. But she and her colleagues are targeting IAPP, tau and alpha-synuclein to treat the underlying causes. She said a multi-targeting approach would be the best option for these chronic diseases.<\/p>\n\n\n\n

\u201cWe aim to offer small-molecule therapeutics that not only prevent aggregation, but also disaggregate already-existing clumps,\u201d Fortin said. \u201cThe body can then eliminate these byproducts and the dual action of these compounds can impede the redistribution of the clumps alongside blood vessels; the risk of such redistribution is intracranial hemorrhage in the brain.\u201d<\/p>\n\n\n\n

Creating treatments for Alzheimer\u2019s and Parkinson\u2019s<\/h2>\n\n\n\n

Fortin and her colleagues have synthesized a library of small-molecule compounds with similar chemical structures for the treatment of Alzheimer\u2019s and Parkinson\u2019s. They measured the compounds\u2019 activity to inhibit protein aggregation at the micromolar level, or one-millionth of a mole per liter.<\/p>\n\n\n\n

\u201cTwo compounds significantly inhibited the formation of oligomers, which are polymers that have relatively few repeating units,\u201d Fortin said. \u201cThese compounds cross the blood-brain barrier and reach the brain in rodent models, which is a big step forward. They stop the formation of inclusions, which are made by the aggregation of alpha-synuclein, in a cell-based model run by my collaborator, Ulf Dettmer at Brigham and Women\u2019s Hospital and Harvard Medical School. We are seeking funding to understand the precise mechanisms of action of these small-molecule terminators of oligomers.\u201d <\/p>\n\n\n\n

Fortin said researchers could administer these Purdue-developed compounds along various pathways by combining them with pharmaceutical carriers like lactose, mannitol and microcrystalline cellulose.<\/p>\n\n\n\n

\u201cThis strategy shows promise as a next-step treatment therapy for Alzheimer\u2019s disease and Parkinson\u2019s disease,\u201d Fortin said. \u201cIt also exhibits potential adaptability for other, analogous neurodegenerative diseases like Huntington\u2019s disease, Lewy body dementia, chronic traumatic encephalopathy, or CTE, and transmissible spongiform encephalopathies, or TSEs.\u201d<\/p>\n\n\n\n

Creating Type 2 diabetes treatments<\/h2>\n\n\n\n

Fortin and her colleagues have discovered three small-molecule compounds that inhibit the formation IAPP, which aggregates in the pancreas of many with Type 2 diabetes.<\/p>\n\n\n\n

\u201cThese small molecules reduced the aggregation of IAPP at about 25-100 micromolar after one hour. They also inhibit the oligomer formation of IAPP,\u201d Fortin said. \u201cThese molecules work on feline and human form of IAPP and could be developed further for human and feline diabetes. They are nontoxic to mouse and rat cancerous beta cell lines. The mechanisms of their action are still under investigation.\u201d <\/p>\n\n\n\n

The next development steps<\/h2>\n\n\n\n

Fortin and her team will continue to develop both lines of treatment at laboratories in the College of Veterinary Medicine and the Purdue Institute for Drug Discovery.<\/p>\n\n\n\n

\u201cWe will conduct additional proof-of-concept studies, focusing on optimizing the effect of the compounds,\u201d Fortin said. \u201cWe also will study the compounds\u2019 pharmacokinetics and pharmacodynamics, or how they move within the body and what effects they have on the body. Preliminary data demonstrated that five representative compounds were present in the brain after injection in mice.\u201d<\/p>\n\n\n\n

Fortin disclosed the compounds to the Purdue Innovates Office of Technology Commercialization<\/a>, which has applied for patents through the U.S. Patent and Trademark Office to protect the intellectual property. Industry partners interested in developing or commercializing the work should contact Joe Kasper, assistant director of business development and licensing \u2014 life sciences, at jrkasper@prf.org<\/a>, about track codes 69967<\/a>, 69996<\/a>, 70004<\/a> and 70255<\/a>.<\/p>\n\n\n\n

About Purdue University<\/h2>\n\n\n\n

Purdue University is a public research institution with excellence at scale. Ranked among top 10 public universities and with two colleges in the top four in the United States, Purdue discovers and disseminates knowledge with a quality and at a scale second to none. More than 105,000 students study at Purdue across modalities and locations, with 50,000 in person on the West Lafayette campus. Committed to affordability and accessibility, Purdue\u2019s main campus has frozen tuition 13 years in a row. See how Purdue never stops in the persistent pursuit of the next giant leap, including its first comprehensive urban campus in Indianapolis, the new Mitchell E. Daniels, Jr. School of Business, and Purdue Computes, at https:\/\/www.purdue.edu\/president\/strategic-initiatives<\/a>.<\/p>\n\n\n\n

About Purdue Innovates Office of Technology Commercialization<\/h2>\n\n\n\n

The Purdue Innovates Office of Technology Commercialization<\/a> operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university\u2019s academic activities through commercializing, licensing and protecting Purdue intellectual property. In fiscal year 2023, the office reported 150 deals finalized with 203 technologies signed, 400 disclosures received and 218 issued U.S. patents. The office is managed by the Purdue Research Foundation, which received the 2019 Innovation and Economic Prosperity Universities Award for Place from the Association of Public and Land-grant Universities. In 2020, IPWatchdog Institute ranked Purdue third nationally in startup creation and in the top 20 for patents. The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University. Contact otcip@prf.org<\/a> for more information.<\/p>\n","protected":false},"excerpt":{"rendered":"

WEST LAFAYETTE, Ind. — Purdue University researchers have taken the first steps to treat Alzheimer\u2019s disease, Parkinson\u2019s disease and Type 2 diabetes by creating multiple patent-pending compounds shown to inhibit protein aggregation associated with those diseases. According to the Centers<\/p>\n","protected":false},"author":7,"featured_media":4701,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[316,7],"tags":[],"department":[24,57],"source":[35],"purdue_today_topic":[66],"coauthors":[44],"class_list":["post-4700","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-prf","category-research-excellence","department-research-foundation","department-veterinary-medicine","source-purdue-research-foundation","purdue_today_topic-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/4700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/comments?post=4700"}],"version-history":[{"count":2,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/4700\/revisions"}],"predecessor-version":[{"id":4706,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/4700\/revisions\/4706"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/media\/4701"}],"wp:attachment":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/media?parent=4700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/categories?post=4700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/tags?post=4700"},{"taxonomy":"department","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/department?post=4700"},{"taxonomy":"source","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/source?post=4700"},{"taxonomy":"purdue_today_topic","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/purdue_today_topic?post=4700"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/coauthors?post=4700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}