{"id":13565,"date":"2025-02-25T09:41:57","date_gmt":"2025-02-25T14:41:57","guid":{"rendered":"https:\/\/www.purdue.edu\/newsroom\/?p=13565"},"modified":"2025-02-25T09:41:59","modified_gmt":"2025-02-25T14:41:59","slug":"high-tech-startup-crysyst-provides-quality-by-control-solutions-for-pharmaceutical-fine-chemical-industries","status":"publish","type":"post","link":"https:\/\/www.purdue.edu\/newsroom\/2025\/Q1\/high-tech-startup-crysyst-provides-quality-by-control-solutions-for-pharmaceutical-fine-chemical-industries","title":{"rendered":"High-tech startup CrySyst provides quality-by-control solutions for pharmaceutical, fine chemical industries"},"content":{"rendered":"\n<p>WEST LAFAYETTE, Ind. \u2014 International process systems and operation experts have launched high-tech startup <a href=\"https:\/\/crysyst.com\/\">Crystallization Systems Technology Inc.<\/a> (CrySyst) to streamline processes used by companies in the pharmaceutical and fine chemical industries.<\/p>\n\n\n\n<p>CrySyst\u2019s quality-by-control (QbC) framework addresses crystallization monitoring, modeling and control. The framework is based on research published in the <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.cgd.0c00295\">April 15, 2020<\/a>, and <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.cgd.1c00904\">Oct. 5, 2021<\/a>, issues of the journal Crystal Growth &amp; Design and the <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.iecr.2c02013\">Sept. 22, 2022<\/a>, issue of the journal Industrial &amp; Engineering Chemistry Research.<\/p>\n\n\n\n<p><a href=\"https:\/\/engineering.purdue.edu\/ChE\/people\/ptProfile?id=79574\">Zolt\u00e1n Nagy<\/a>, the Arvind Varma Professor of Chemical Engineering in Purdue University\u2019s <a href=\"https:\/\/engineering.purdue.edu\/ChE\">Davidson School of Chemical Engineering<\/a>, and Botond Szil\u00e1gyi, formerly a postdoctoral research associate at Purdue and now an associate professor at <a href=\"https:\/\/www.bme.hu\/\">Budapest University of Technology and Economics<\/a>, founded CrySyst.<\/p>\n\n\n\n<p>The <a href=\"https:\/\/purdueinnovates.org\/otc\/\">Purdue Innovates Office of Technology Commercialization<\/a> has issued a license for CrySyst to commercialize copyright technologies CryMoCo and CrySIV.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CrySiV and CryMoCo software solutions<\/h2>\n\n\n\n<p>Nagy said the most significant challenges in model-based process development are determining which experiments are necessary, selecting the most appropriate model structures and obtaining reliable model parameters.<\/p>\n\n\n\n<p>\u201cCrySyst\u2019s tools directly address these pain points by providing guided experiment selection, offering a semiautomated framework for model development, and delivering reliable, high-confidence solutions,\u201d he said.<\/p>\n\n\n\n<p>Nagy said CrySiV and CryMoCo provide a streamlined, systematic and scientifically rigorous approach to crystallization process development.<\/p>\n\n\n\n<p>\u201cThese tools reduce time, material usage and risk while enhancing process robustness and scalability,\u201d he said.<\/p>\n\n\n\n<p>CryMoCo is instrument vendor-independent crystallization process monitoring and control software. It implements industry-standard communication protocols with typical process analytical technology tools and state-of-the-art process control methods, including direct nucleation control and supersaturation control approaches.<\/p>\n\n\n\n<p>\u201cThis enables the rapid direct design of robust crystallization processes using our innovative QbC framework,\u201d Nagy said.<\/p>\n\n\n\n<p>CrySiV is a user-friendly, interactive population balance model-based crystallization simulator for digital design of crystallization processes. It includes kinetic parameter regression, process simulation and visualization.<\/p>\n\n\n\n<p>\u201cCrySiV also includes process optimization features for both crystallization and integrated crystallization-wet milling processes, using state-of-the-art numerical methods for modeling and optimization,\u201d Nagy said.<\/p>\n\n\n\n<p>Nagy said CryMoCo and CrySiV provide:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>An intuitive and user-friendly interface, reducing the learning curve for industry professionals<\/li>\n\n\n\n<li>State-of-the-art numerical solvers, ensuring reliable, reproducible solutions that also enable rigorous model validation<\/li>\n\n\n\n<li>A structured workflow, guiding users through model selection and refinement while minimizing computational uncertainties<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Industry pain points in process development<\/h2>\n\n\n\n<p>Nagy said pharmaceutical and fine chemical companies face process development challenges due to limited material availability, constraints on experimental resources and extensive timelines required for optimization through experiments only.<\/p>\n\n\n\n<p>\u201cThese challenges can be effectively addressed through model-based digital design and model-free direct design approaches, which have seen increasing adoption,\u201d he said. \u201cHowever, to achieve widespread implementation, there is a critical need for systematic workflows and robust tools to support their integration into industrial practice. This is what CrySyst solutions address. We are committed to helping our clients develop and scale their process technologies faster, using less material. We offer specialized software products for model-free and model-based crystallization process design as well as consultancy and training services for problem-solving with our software tools.\u201d<\/p>\n\n\n\n<p>Nagy and Szil\u00e1gyi received funding from the Enabling Technologies Consortium.<\/p>\n\n\n\n<p>\u201cThe consortium included more than 10 of the largest pharmaceutical companies,\u201d Nagy said. \u201cWe collaborated on a project with them for three years and, through close interaction with the crystallization scientists from the member companies, we developed the tools based on feedback we received to fit the needs of the industry.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">About Crystallization Systems Technology<\/h2>\n\n\n\n<p><a href=\"https:\/\/crysyst.com\/\">Crystallization Systems Technology<\/a> is committed to helping pharmaceutical and fine chemical industries develop and scale-up their process technologies faster, using less material by the application of cutting-edge crystallization monitoring, modeling and control solutions. We offer specialized software products for model-free and model-based crystallization process design as well as consultancy and training services for problem-solving with our software.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">About Purdue Innovates Office of Technology Commercialization<\/h2>\n\n\n\n<p>The <a href=\"https:\/\/purdueinnovates.org\/otc\/\">Purdue Innovates Office of Technology Commercialization<\/a> operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university\u2019s academic activities through commercializing, licensing and protecting Purdue intellectual property. In fiscal year 2024, the office reported 145 deals finalized with 224 technologies signed, 466 invention disclosures received, and 290 U.S. and international patents received. The office is managed by the Purdue Research Foundation, a private, nonprofit foundation created to advance the mission of Purdue University. Contact <a href=\"mailto:otcip@prf.org\">otcip@prf.org<\/a> for more information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">About Purdue University<\/h2>\n\n\n\n<p>Purdue University is a public research university leading with excellence at scale. Ranked among top 10 public universities in the United States, Purdue discovers, disseminates and deploys knowledge with a quality and at a scale second to none. More than 107,000 students study at Purdue across multiple campuses, locations and modalities, including more than 58,000 at our main campus in West Lafayette and Indianapolis. Committed to affordability and accessibility, Purdue\u2019s main campus has frozen tuition 13 years in a row. See how Purdue never stops in the persistent pursuit of the next giant leap \u2014 including its comprehensive urban expansion, the Mitch Daniels School of Business, Purdue Computes and the One Health initiative&nbsp;\u2014 at&nbsp;<a href=\"https:\/\/www.purdue.edu\/president\/strategic-initiatives\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.purdue.edu\/president\/strategic-initiatives<\/a><\/p>\n\n\n<div id=\"note\" class=\"post-content__attribution \">\n    <div class=\"columns\"> \n                    <div class=\"column\"> \n                <p class=\"post-content__source\">\n                    <strong>Media contact:<\/strong> Steve Martin, <a href=\"mailto:sgmartin@prf.org\">sgmartin@prf.org<\/a>                <\/p>\n            <\/div>\n                    <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>WEST LAFAYETTE, Ind. \u2014 International process systems and operation experts have launched high-tech startup Crystallization Systems Technology Inc. (CrySyst) to streamline processes used by companies in the pharmaceutical and fine chemical industries. CrySyst\u2019s quality-by-control (QbC) framework addresses crystallization monitoring, modeling<\/p>\n","protected":false},"author":25,"featured_media":13517,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[316],"tags":[],"department":[],"source":[35],"purdue_today_topic":[],"coauthors":[44],"class_list":["post-13565","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-prf","source-purdue-research-foundation"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/13565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/comments?post=13565"}],"version-history":[{"count":1,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/13565\/revisions"}],"predecessor-version":[{"id":13566,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/posts\/13565\/revisions\/13566"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/media\/13517"}],"wp:attachment":[{"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/media?parent=13565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/categories?post=13565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/tags?post=13565"},{"taxonomy":"department","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/department?post=13565"},{"taxonomy":"source","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/source?post=13565"},{"taxonomy":"purdue_today_topic","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/purdue_today_topic?post=13565"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.purdue.edu\/newsroom\/wp-json\/wp\/v2\/coauthors?post=13565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}