Susan Sangha

Degree: Ph.D. University of Calgary, Canada, 2005

Research Interests:

Clinical disorders arising from maladaptive emotion regulation present a large burden on society worldwide. Many of these disorders show comorbidity, for example, addiction with anxiety disorders. Even though there has been much research on reward and fear processing, the majority of studies have been conducted in parallel, investigating the circuitries separately. If we hope to understand and treat comorbid disorders resulting from maladaptive emotion regulation we need to increase our efforts in investigating how these circuitries integrate their functions to influence behavior. This is the focus of the Sangha Lab. We have developed a novel behavioral paradigm explicitly designed to assess reward, fear and safety cue learning together in order to investigate the multiple circuitries that regulate these learning processes. Using a combination of behavioral, electrophysiological and pharmacological techniques, we track biological changes in the rat brain as it is learning about reward, fear, and safety signals.

Representative Publications:

Christianson JP, Fernando ABP, Kazama AM, Jovanovic T, Ostroff LE, Sangha S (2012). Inhibition of fear by learned safety signals: minisymposium review. Journal of Neuroscience, 32(41): 14118-14124.

Sangha S, Chadick JZ, Janak PH (2013). Safety encoding in the basal amygdala. Journal of Neuroscience, 33: 3744-3751.

Sangha S, Robinson PD, Davies DA, Greba Q, Howland JG (2014). Alterations in reward, fear and safety cue discrimination after inactivation of the prelimbic and infralimbic cortices. Neuropsychopharmacology, 39:2405-2413.

Sangha S, Greba Q, Robinson PD, Ballendine SA, Howland JG (2014). Normal fear and safety cue discrimination but alterations in fear regulation after extinction in an animal model of schizophrenia. Front Behav Neurosci, 8: 168.

Sangha S (2015). Plasticity of fear and safety neurons of the amygdala in response to fear extinction. Front Behav Neurosci, 9: 354.

Ng K, Pollock MW, Urbanczyk PJ, Sangha S (2018). Altering D1 receptor activity in the basolateral amygdala impairs fear suppression during a safety cue. Neurobiology of Learning and Memory 147: 26-34.

Müller I, Brinkman AL, Sowinski EM, Sangha S (2018). Adolescent conditioning affects rate of adult fear, safety and reward learning during discriminative conditioning. Scientific Reports, 8: 17315.

Sangha S, Foti D (2018). Neurobiology of Abnormal Emotion and Motivated Behaviors: Integrating Animal and Human Research. 1st edition. Cambridge, Massachusetts: Academic Press.

Greiner EM, Müller I, Norris MR, Ng KH, Sangha S (2019). Sex differences in fear regulation and reward-seeking behaviors in a fear-safety-reward discrimination task. Behavioural Brain Research, 368: 111903.

Sangha S, Diehl M, Bergstrom H, Drew M (2020). Know Safety, No Fear. Neuroscience & Biobehavioral Reviews 108: 218-230.

Woon EP, Seibert TA, Urbanczyk PJ, Ng KH, Sangha S (2020). Differential effects of prior stress on conditioned inhibition of fear and fear extinction. Behavioural Brain Research 381: 112414.


Susan Sangha

Associate Professor, Neuroscience

Mailing Address:
Department of Psychological Sciences
Purdue University
703 Third Street
West Lafayette, IN 47907-2081 USA

Campus Address:
Psychological Sciences, Room 3182

Telephone: (765) 494-0648
CV: Susan Sangha.pdf

Psychological Sciences, 703 Third Street, West Lafayette, IN 47907, (765) 494-6061 FAX: (765) 496-1264

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