Amy Brewster

Degree: Ph.D. University of California-Irvine, 2006

Research Interests:

My general research interests are to study mechanisms that underlie molecular and structural dendritic alterations, seizures, and behavioral deficits in epilepsy.

Recent Publications:

Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, Mukhi S, Parghi D, D'Arcangelo G, Anderson AE. (2011) mTORC1 inhibition prevents epileptogenesis and reverses mossy fiber sprouting in NS-Pten knockout mice. Epilepsia 52(11):2065-2075.

Surges R, Kukley M, Brewster A, Rüschenschmidt C, Schramm J, Baram TZ, Beck H, Dietrich D. (2012) Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem. Biophys. Res. Commun. 420(1):156-160.

Lugo JN, Brewster AL, Spencer CM, Anderson AE. (2012) Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning and Memory 19(5):182-189.

Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C. (2012) Differential dorso-ventral distributions of Kv4.2 and hyperpolarization-activated cyclic adenosine monophosphate gated channel (HCN) proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. J Biol Chem. 287(21):17656-17661.

Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, Anderson AE. (2013) Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLOS ONE 8 (3), e57808

Sierra*, A., S, Valcarcel-Martin, R., Pascual-Brazo, J., Aelvoet, S.A., Abiega, O., Deudero, J.J.P, Brewster, A.L., Bernales, A., Anderson, A.E., Baeckelandt, V., Maletic-Savatic, M., Encinas, J.M. (2015). Induction of reactive neural stem cells and impairment of hippocampal neurogenesis due to neuronal hyperactivity. Cell Stem Cell. 16(5):488-503.

Nguyen*, L.H., Brewster, A.L., Clark, M., Regnier-Golanov, A., Sunnen, N.C., Patil, V.V., Anderson, A.E. (2015). mTOR inhibition suppresses established epilepsy in the NS-Pten knockout mouse model of cortical dysplasia. Epilepsia. 56(4):636-46.

Brewster*, A.L., Marzec, K., Hairston, A., Ho, M, Anderson, A.E., Lai, Y.C. (2016). Early electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy. Epilepsia, 7(11):1907-1915.

Schartz*, N.D., Herr, S.A., Madsen, L., Butts, S. J., Torres, C. Mendez, L.B., Brewster*, A.L.  Spatiotemporal profile of Map2 and microglial changes in the hippocampus following pilocarpine-induced status epilepticus. Scientific Reports, srep24988, 2016.

Abiega*, O., Becari, S., Diaz-Aparicio, I., Nadjarm, A., Layé, S., Leyrolle, Q., Gomez-Nicola, D., Domercq, M., Pérez, A., Sánchez-Zafra, V., Paris, I., Deudero, J.J.P., Brewster, A.L., Anderson, A.E., Zaldumbide, L., Galbarriatu, L., Marinas, A., Vivanco, M.dM., Matute, C., Maletic-Savatic, M., Encinas, J.M., Sierra, A. (2016). Neuronal hyperactivity disturbs ATP microgradients, impairs microglial motility, and reduces phagocytic receptor expression triggering apoptosis/microglial phagocytosis uncoupling. PLOS Biology, 14(5): e1002466.

Wyatt-Johnson, SK, Herr, S.A., & Brewster, A.L. (2017). Status epilepticus triggers time dependent alterations in microglia abundance and morphological phenotypes in the hippocampus. Frontiers in Neurology, 8:700.

Wyatt, S.K., Witt, T., Barbaro, N.M. Cohen-Gadol, A.A., & Brewster, A.L. (2017). Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy. Experimental Neurology, 295:184-193.

Schartz, N. D., Wyatt-Johnson, S.K., Price, L. R., Colin, S. A. & Brewster, A. L. (2018). Status  epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy. Neurobiology of Disease, 109, 163-173. 



Amy Brewster

Associate Professor, Neuroscience and Behavior

Mailing Address:
Department of Psychological Sciences
Purdue University
703 Third Street
West Lafayette, IN 47907-2081 USA

Campus Address:
Psychological Sciences, Room 1144

Telephone: (765) 494-5075
CV: Amy Brewster.pdf

Psychological Sciences, 703 Third Street, West Lafayette, IN 47907, (765) 494-6061 FAX: (765) 496-1264

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