A SAAM31          PK8.saam               8/1/98 
C FIRST ORDER ELIMINATION   
C    -TWO COMPARTMENT MODEL WITH IV INFUSION DOSE   
C ALL LINES THAT BEGIN WITH C ARE COMMENTS  
H PAR   
C THIS IS THE PARAMETERS SECTION
C IC(1) IS THE INITIAL CONDITION OF COMPARTMENT ONE (DOSE)  
C L(0,1) IS THE FRACTION LOST PER UNIT TIME 
C P(1) IS THE VOLUME OF DISTRIBUTION
   IC(1)     1000   
   L(0,1)    0.01   
   L(2,1)    0.1
   L(1,2)    0.005  
   P(1)      10 
H DAT   
C THIS IS THE DATA SECTION AND CAN INCLUDE BOTH EQUATIONS   
C     AND DATA POINTS   
C  UF(1) IS THE CONSTANT INFUSION INTO COMPARTMENT ONE  
XUF(1)=F(11)
C THIS SECTION BEGINS THE INFUSION (5 DOSE/TIME) AT TIME=1  
C    AND ENDS IT AT TIME=500
111QO   
            0   
            1             5 
            500           0 
C G(1) IS THE CONCENTRATION OF COMPARTMENT ONE  
C    IT IS EQUAL TO THE CURRENT AMMOUNT (F) DIVIDED BY THE  
C    VOLUME (P) 
XG(1)=F(1)/P(1) 
C THIS SECTION DICTATES WHEN TO MAKE THE CALCULATIONS   
101G(1) 
            0   
2           10                           100
C  TO USE DATA TO FIT THE MODEL, ENTER AS SHOWN 
C  WITH TIME IN COLUMN 13 AND CONCENTRATION IN  
C  COLUMN 27. THEN DELETE THE Cs IN COLUMN 1
C101G(1)
C           0.  
C           10            77
C           20            71
C           30            58
C  **** END OF MODEL**********************************  

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