A SAAM31 PK3b.saam 8/1/98 C FIRST ORDER ELIMINATION C -ONE COMPARTMENT MODEL WITH IV BOLUS DOSE C -FIRST ORDER ABSORPTION AND LAG C ALL LINES THAT BEGIN WITH C ARE COMMENTS H PAR C THIS IS THE PARAMETERS SECTION C IC(1) IS THE INITIAL CONDITION OF COMPARTMENT ONE (DOSE) C L(0,3) IS THE FRACTION LOST PER UNIT TIME C L(2,1) IS THE FRACTION TRANSFERRED PER UNIT TIME C L(3,2) IS THE FRACTION TRANSFERRED PER UNIT TIME C P(3) IS THE VOLUME OF DISTRIBUTION C DT(2) IS THE TIME LAG OF COMPARTMENT TWO C DN(2) IS A TERMINATION SPEED IC(1) 1000 L(0,3) 0.01 DT(2) 50 DN(2) 4 L(3,2) 0.01 L(2,1) 0.01 P(3) 10 H DAT C THIS IS THE DATA SECTION AND CAN INCLUDE BOTH EQUATIONS C AND DATA POINTS C G(3) IS THE CONCENTRATION OF COMPARTMENT THREE C IT IS EQUAL TO THE CURRENT AMMOUNT (F) DIVIDED BY THE C VOLUME (P) XG(3)=F(3)/P(3) C THIS SECTION DICTATES WHEN TO MAKE THE CALCULATIONS C IN THIS CASE, EVERY 10 UNITS, 100 TIMES, STARTING AT 0 103G(3) 0 2 10 100 C TO USE DATA TO FIT THE MODEL, ENTER AS SHOWN C WITH TIME IN COLUMN 13 AND CONCENTRATION IN C COLUMN 27. THEN DELETE THE Cs IN COLUMN 1 C101G(1) C 0. C 10 77 C 20 71 C 30 58 C **** END OF MODEL********************************** ÿ