Model 11: Fluid-Phase Endocytosis
A SAAM31 ENDOCYTOSIS.S
C DECK FROM MIKE GREEN, PENNSYLVANIA STATE UNIVERSITY
C Ref: Blomhoff R, Nenseter MS, Green MH and Berg T. A
C multicompartmental model of fluid-phase endocytosis in rabbit
C liver parenchymal cells. Biochem J 262:605-610, 1989.
CA SAAM31 RABPC.112 (06/12-88)
C
C FLUID PHASE ENDOCYTOSIS IN SUSPENDED RABBIT
C PARENCHYMAL CELLS.
C
C UPTAKE OF PVP FOR 240 MIN. (MEAN OF RESULTS FROM
C 28/1, 17/2, 16/9 AND 17/9)
C
C RELEASE OF PVP AFTER 20, 60 AND 120 MIN OF
C CONTINOUS UPTAKE. (MEAN OF RESULTS FROM 28/1,
C 17/2, 16/9 AND 17/9)
C
2 10
H PAR
IC(1)=100
IC(5)=P(5)
IC(21)=P(21)
IC(6)=100-P(5)-P(21)
IC(8)=P(8)
IC(22)=P(22)
IC(9)=100-P(8)-P(22)
IC(11)=P(11)
IC(23)=P(23)
IC(12)=100-P(11)-P(23)
L(1,2) 8.581533E-02 0.000000E+00 1.000000E+00
L(2,1) 4.692068E-05 0.000000E+00 1.000000E-01
L(3,2) 2.233459E-02 0.000000E+00 1.000000E+00
L(1,3) 2.412019E-02 0.000000E+00 1.000000E+00
L(20,3) 4.142378E-02 0.000000E+00 1.000000E+00
L(1,20) 3.184077E-03 0.000000E+00 1.000000E+00
P(5) 1.709295E+01 1.500000E+01 5.000000E+01
P(8) 2.299999E+01 2.000000E+01 4.000000E+01
P(11) 5.989899E+00 5.000000E+00 3.000000E+01
P(21) 7.676767E-02 0.000000E+00 1.500000E+01
P(22) 3.000000E+01 1.000000E+00 4.000000E+01
P(23) 4.000000E+01 1.000000E+01 8.000000E+01
L(5,4)=L(2,1)
L(4,5)=L(1,2)
L(6,5)=L(3,2)
L(4,6)=L(1,3)
L(21,6)=L(20,3)
L(4,21)=L(1,20)
L(8,7)=L(2,1)
L(7,8)=L(1,2)
L(9,8)=L(3,2)
L(7,9)=L(1,3)
L(22,9)=L(20,3)
L(7,22)=L(1,20)
L(11,10)=L(2,1)
L(10,11)=L(1,2)
L(12,11)=L(3,2)
L(10,12)=L(1,3)
L(23,12)=L(20,3)
L(10,23)=L(1,20)
H DAT
101
0.0
2 1 15
2 5 45
113G(13)
0.0
2 1 15
2 5 45
104
0
2 1 15
2 5 41
114G(14)
0
2 1 15
2 5 41
107
0
2 1 15
2 5 33
115G(15)
0
2 1 15
2 5 33
110
0
2 1 15
2 5 21
116G(16)
0
2 1 15
2 5 21
C
H DAT
C DATA FROM UPTAKE EXPERIMENT
C
101 FSD=.068
10 99.966
20 99.956
30 99.940
60 99.916
120 99.899
240 99.842
113G(13) FSD=.068
XG(13)=F(2)+F(3)+F(20)
10 .034
20 .044
30 .060
60 .084
120 .101
240 .158
C
C DATA FROM RELEASE AFTER 20 MIN LOADING
C
104 FSD=.068
10 24.0
20 34.3
30 48.8
60 50.4
120 57.6
220 72.1
114G(14) FSD=.068
XG(14)=F(5)+F(6)+F(21)
10 76.0
20 65.7
30 51.2
60 49.6
120 42.4
220 27.9
C
C DATA FROM RELEASE AFTER 60 MIN LOADING
C
107 FSD=.068
10 21.3
20 29.6
30 38.0
60 45.3
120 54.6
160 58.7
115G(15) FSD=.068
XG(15)=F(8)+F(9)+F(22)
10 78.7
20 70.4
30 62.0
60 54.7
120 45.4
160 41.3
C
C DATA FROM RELEASE AFTER 120 MIN LOADING
C
110 FSD=.068
20 20.5
30 26.2
60 35.1
90 40.5
120 49.6
116G(16) FSD=.068
XG(16)=F(11)+F(12)+F(23)
20 79.5
30 73.8
60 64.9
90 59.5
120 50.4
C ***** END OF MODEL