Connie M. Weaver

Links

Educational Background

  • B.S., Nutrition at Oregon State University in 1972
  • M.S., Nutrition at Oregon State University in 1974
  • Ph.D., Nutrition at Florida State University in 1978

Awards & Honors

  • David Kritchevsky Career Achievement Award, ASN, 2017
  • Member, Institute of Medicine from National Academy of Science, 2010 - Present
  • Purdue Spirit of the Land Grant, 2013
  • Herbert Newby McCoy Award from Purdue University, 2012
  • Linus Pauling Research Award from Oregon State University, 2011
  • Gilbert A. Leveille Lectureship Award from ASN/IFT, 2011
  • Burton Kallman Scientific Award from National Products Association, 2010
  • ASN Robert H Herman Award from American Society for Nutrition, 2009
  • Harris Award from Ohio State University, 2008
  • Sigma Xi Faculty Research Award from Sigma Xi, 2006
  • Foods and Nutrition Hall of Fame from Purdue University, 2006
  • Centennial Laureate Award from Florida State University, 2005
  • Career Award from American College of Nutrition, 2005
  • W. O. Atwater Lecturership from Agricultural Research Service, USDA and American Society for Nutritional Sciences, 2003
  • Distinguished Professor of Foods and Nutrition from Purdue University, 2000

Activities & Memberships

  • Member (Food and Nutrition Board), Institute of Medicine, National Academy of Science, 2010
  • Member (Past President ), American Society for Nutrition, 1997
  • Member (Fellow), American College of Nutrition , 1995
  • Member (Editorial Board ), American Society for Bone and Mineral Research, 1989 - Present
  • Member (Purdue Chapter), Sigma Xi , 1978
  • Member (Member), Institute of Food Technologists, 1978

Discovery/Contributions to Science

A full list of my published work can be found at http://www.ncbi.nlm.nih.gov/sites/myncbi/connie.weaver.1/bibliography/40779125/public/?sort=date&direction=ascending

Development of peak bone mass and mineral requirements. My research team conducted 11 controlled feeding studies funded by NIH from 1990 to 2014. These were run as summer research camps (i.e. “camp calcium”) to determine diet, sex, and racial influences on metabolism of calcium and other bone minerals. Results from these studies were used to set bone mineral requirements for adolescents in North America by the Institute of Medicine Food and Nutrition Board.

  • Palacios C, Martin BR, McCabe GP, McCabe L, Peacock M, Weaver CM. Dietary calcium requirements do not differ between Mexican American boys and girls. J Nutr 144:1167-1173, 2014.
  • Hill KM, Braun MM, Egan KA, Martin BR, McCabe LD, Peacock M, McCabe GP, Weaver CM. Obesity augments calcium-induced increases in skeletal calcium retention in adolescents. J Clin Endocrinol Metab 96:2171-7, 2011.
  • Wu L, Martin BR, Braun MM, Wastney ME, McCabe GP, McCabe LD, DiMeglio LA, Peacock M, Weaver CM. Calcium requirements and metabolism in Chinese American boys and girls. J Bone Miner Res 25(8):1842-9, 2010.
  • The original individual data and key references are available to the public at https://www.indianactsi.org/

Development of rapid screening method for bone loss therapies using 41Ca.
Our group developed a method to rapidly and Botanical Supplement Interventions Compared to Traditional Therapy for Effects on Bone Calcium Retention in Postmenopausal Womensensitively evaluate the efficacy of interventions to prevent bone loss using urinary appearance of the rare isotope, 41Ca, from pre-labeled bone. Interventions can be assessed in 50 days in humans or 10 days in rats compared to traditional multi-year bone mineral density trials. The method can be used to compare multiple treatments in the same subjects using a crossover design. This method was developed through the NIH Purdue-UAB Botanical Research Center for which I was the Director.

  • Jakeman SA, Henry CN, Martin BR, McCabe GP, McCabe LD, Jackson JS, Peacock M, Weaver CM. Soluble corn fiber increases bone retention in postmenopausal women in a dose-dependent manner: a randomized crossover trial. Amer J Clin Nutr 104:837-43. 2016.
  • Pawlowski J, Martin B, McCabe G, McCabe L, Jackson G, Peacock M, Barnes S, Weaver CM. Impact of equol producing capacity and soy isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a partially randomized crossover trial. Am J Clin Nutr 102:695-703, 2015
  • Pawlowski J, Martin B, McCabe G, Ferruzzi M, Weaver, C. Plum and soy aglycon extracts superior at increasing bone calcium retention in ovariectomized Sprague Dawley rats. J Ag Food Chem. 62:6108-14, 2014.
  • Cheong JMK, Gunaratna NS, McCabe GP, Jackson JS, Weaver CM. Bone seeking labels as markers for bone turnover: effect of dosing schedule on labeling various bone sites in rats. Calcif. Tissue Intl. 85(5): 444-450, 2009.
  • Weaver CM, Martin BR, Jackson GS, McCabe GP, Nolan JR, McCabe LD, Barnes S, Reinwald S, Boris ME, Peacock M. Antiresorptive effects of phytoestrogen supplements compared to estradiol or Risedronate in postmenopausal women using 41Ca methodology. J Clin Endocrinol Metab. 94(10): 3798-3805, 2009.

Diet and Gut Microbiome. Diet can alter gut microbial communities in ways that influence health. We found that prebiotic (nondigestible) fiber consumption increases calcium absorption in pubertal children, postmenopausal women, and animal models. Shifts in microbial communities were significantly associated with increases in calcium absorption. This is the first functional benefit of altered gut micribiome to be reported in healthy individuals. I was the Principal Investigator of a series of projects.

  • Whisner CM, Martin BR, Nakatsu, CH, Story JA, MacDonald-Clarke CJ, McCabe LD, McCabe GP, Weaver CM. Soluble corn fiber increases calcium absorption associated with shifts in the gut microbiome. A randomized dose-response trial in free-living pubertal girls. J Nutr 146: 1298-306, 2016.
  • Jakeman SA, Henry CN, Martin BR, McCabe GP, McCabe LD, Jackson JS, Peacock M, Weaver CM. Soluble corn fiber increases bone retention in postmenopausal women in a dose-dependent manner: a randomized crossover trial. Amer J Clin Nutr 104:837-43. 2016.
  • Nakatsu CH, Weaver CM, Martin BR, Clavijo A, Barnes S. Fecal bacterial community changes associated with isoflavone metabolites in postmenopausal women after soy bar consumption. PLOS One 9:e108924, 2014.
  • Whisner CM, Martin BR, Schoterman MHC, Nakatsu CH, McCabe LD, McCabe GP, Wastney ME, van den Heuvel EGHM, Weaver CM. Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: A double blind crossover trial. Br J Nutr 110:1292-1303, 2013.

Diet and Cardiovascular Risk. We have been studying the influence of dietary minerals on risk of cardiovascular disease and coronary artery calcification funded by NIH and industry for 30 years. We have demonstrated racial differences in mineral metabolism and nutrient interactions with relevance to modulating blood pressure and kidney damage. Underlying racial differences in mineral metabolism can explain racial differences in hypertension and osteoporosis. Our team has used calcium tracer kinetics to measure early soft tissue calcification. This approach detects adverse changes much earlier than can be observed with current diagnostic imaging approaches like PET-CT.

  • Weaver CM, Martin, BR, McCabe GP, McCabe LD, Woodward M, Anderson CAM, Appel LJ. Individual variation in urinary sodium excretion among adolescent girls on a fixed intake. J Hyperten 34:1290-1297, 2016
  • Kopecky SL, Bauer DC, Gulati M, Nieves JW, Singer AJ, Toth PP, Underberg JA, Wallace, TC, Weaver CM. Lack of evidence linking calcium with or without vitamin D supplementation to cardiovascular disease in generally healthy adults: A position statement from The National Osteoporosis Foundation and American Society for Preventive Cardiology Ann Intern Med 2016 (ePub ahead of print) DOI:10.7326/M16-1743.
  • Wastney M, Lee W, Jackson GS, Alloosh M, Sturek, Lachcik P, Peacock M, Martin B, Weaver CM. Soft tissue calcification in the Ossabaw miniature pig: experimental and kinetic modeling studies. Osteoporos Intl 24:2123-2126, 2012.
  • Palacios C, Wigertz K, Martin BR, Jackman L, Pratt JH, Peacock M, McCabe G, Weaver CM. Sodium retention in black and white female adolescents in response to salt intake. J Clin Endocrin Metab 89(4):1858-1863, 2004.

Learning

NUTR 40000 Executive in the Classroom: Lecture and discussion, featuring industry and business executives in food-related areas. Emphasis is placed on careers in the food industry.
NUTR 59000 Basic Bone Biology: This course is intended to provide the fundamental elements of bone biology to graduate students interested in musculoskeletal biology. Topics will include: Cellular/molecular regulation of bone cells; Tissue composition and regulation by remodeling; Bone imaging; Fracture healing; Biomaterials; Mineral homeostasis; PTH, sex steroid, systemic hormone effects on bone; Metabolic bone diseases; Nutrition/Exercise/Pharmaceutical effects on bone; Cancer effects on the bone; Skeletal genetics. Students will also learn how to critically evaluate the scientific literature through a series of journal club presentations. Typically offered Fall (alternate years).
NUTR 60500 Nutritional Biochemistry and Physiology I: The course goal is to provide a foundation in the scientific concepts relevant to nutrient metabolism and nutrient-disease interaction. Dr. Weaver contributes lectures on metabolism methodology and calcium.

Connie Weaver

Distinguished Professor

Office: STON 220-B
Phone: 765.494.8237
Fax: 765.494.0674
E-Mail: weavercm@purdue.edu

Department of Nutrition Science, 700 W. State Street, West Lafayette, IN 47907-2059(765) 494-8228, Fax: (765) 494-0674

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