Greg Henderson

Educational Background

  • B.A., Integrative Biology, University of California, Berkeley, 2001
  • Ph.D., Integrative Biology, University of California, Berkeley, 2007
  • Post-Doc, Division of Endocrinology, Mayo Clinic, Rochester, MN (2007 – 2010)

Dissertation Title

Energy Substrate Partitioning during Post-Exercise Recovery

Awards & Honors

  • Star Reviewer, American Physiological Society Journals (2013)
  • Vernon R. Young International Award for Amino Acid Research, American Society for Nutrition (2011)
  • Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award for Meritorious Research, American Physiological Society.  Experimental Biology Annual Meeting (2007)
  • Predoctoral Recognition Award, American Physiological Society, Environmental and Exercise Physiology Section.  Experimental Biology Annual Meeting (2007)


Lipid metabolism plays a critical role in the supply of fuel to various tissues, and it is physiologically important to alter the rate of lipid shuttling between tissues and cellular compartments as energy needs change throughout the day.  Improper  regulation of lipid metabolism leads to enhanced risk for metabolic and cardiovascular disease.  My laboratory studies lipid metabolism at a biochemical level and in vivo, with focus on lifestyle factors such as energy balance, exercise, and diet selection.  Specifically, we study responses of free fatty acid mobilization, lipoprotein kinetics, and accumulation of various lipids within tissues such as the liver.  The overall goal is to understand how lipid metabolism responds to physiological stressors and healthful lifestyle factors.

Discovery Publications

Koh JH, Johnson ML, Dasari S, Lebrasseur NK, Vuckovic I, Henderson GC, Cooper S, Shulman GI, Lanza IR, Nair KS.  TFAM enhances fat oxidation and attenuates high fat diet induced insulin resistance in skeletal muscle. Diabetes 68(8):1552-1564, 2019.

Tuazon MA, Campbell SC, Klein DJ, Shapses S, Anacker KR, Anthony TG, Uzumcu M, Henderson GC. Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice. Metabolism: Clinical and Experimental 83:234-244, 2018.

Bloomer SA, Wellen KE, Henderson GC. Sexual dimorphism in the hepatic protein response to a moderate trans fat diet in senescence-accelerated mice. Lipids in Health and Disease 16(1):243, 2017.

Davitt PM, Henderson GC, Walker AJ, Arent SM. Postprandial hormone response after endurance or resistance exercise in obese women. Comparative Exercise Physiology 13(4): 227-235, 2017.

Henderson GC. Lipid-Based Therapeutic Strategies for Sarcopenic and Dystrophic Muscular Impairments. Cellular and Molecular Biology 61:2, 2015.

Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS. Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age. Journal of Clinical Endocrinology and Metabolism 100(4): 1654-63. 2015.

Johnson ML, Irving BA, Lanza IR, Vendelbo MH, Konopka AR, Robinson MM, Henderson GC, Klaus KA, Morse DM, Heppelmann C, Bergen HR, Dasari S, Schimke JM, Jakaitis DR, Nair KS. Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.  Journal of Gerontology A: Biological Sciences and Medical Sciences 70(11):1386-93, 2015.

Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon J, Henderson GC, Wek RC, Anthony TG. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. American Journal of Physiology: Endocrinology and Metabolism 308(4): E283-93, 2015.

Henderson GC. Sexual dimorphism in the effects of exercise on metabolism of lipids to support resting metabolism. Frontiers in Endocrinology 2014 Oct 7;5:162.

Tuazon MA, McConnell TR, Wilson GJ, Anthony TG, Henderson GC. Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise. Journal of Applied Physiology 118: 61-70, 2015.

Henderson GC, Evans NP, Grange RW, Tuazon MA.  Compared with monounsaturated fatty acids, a high dietary intake of n-3 polyunsaturated fatty acids does not reduce the degree of pathology in mdx mice. British Journal of Nutrition 111:1791-800, 2014

Henderson GC, Alderman BL.  Determinants of resting lipid oxidation in response to a prior bout of endurance exercise. Journal of Applied Physiology 116: 95-103, 2014.

Liou J, Tuazon MA, Burdzy A, Henderson GC. Moderate compared to low dietary intake of trans-fatty acids impairs strength of old and aerobic capacity of young SAMP8 mice in both sexes. Lipids 48: 1135-1143, 2013.

Tuazon MA, Henderson GC. Fatty acid profile of cardiac muscle phospholipid and triacylglycerol in mdx mice and C57BL/10ScSnJ controls. Lipids 48: 849-51, 2013.

Davitt PM, Arent SM, Tuazon MA, Golem DL, Henderson GC. Postprandial triglyceride and free fatty acid metabolism in obese women after either endurance or resistance exercise. Journal of Applied Physiology 114: 1743-1754, 2013.

Henderson GC. Kinetic measurement techniques in the evaluation of lipid metabolism. Current Drug Discovery Technologies 10: 209-23, 2013.

Sinner DI, Kim JY, Henderson GC, Igal RA. StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation. PLoS ONE 7: e39787, 2012.

Soop M, Nehra V, Henderson GC, Boirie Y, Ford GC, Nair KS. Co-ingestion of whey protein and casein in a mixed meal - demonstration of a more sustained anabolic effect of casein.  American Journal of Physiology: Endocrinology and Metabolism 303: E152-62, 2012.

Tuazon MA, Henderson GC. Fatty acid profile of skeletal muscle phospholipid is altered in mdx mice and is predictive of disease markers. Metabolism: clinical and experimental 61: 801-811, 2012.

Henderson GC, Tuazon MA. Separation of positional and geometrical fatty acid isomers as 2-nitrophenylhydrazide derivatives by high performance liquid chromatography. Analytical Biochemistry 413: 66-68, 2011.

Jaleel A, Henderson GC, Madden BJ, Klaus KA, Morse DM, Gopala S, Nair KS. Identification of de novo synthesized and relatively older proteins – Accelerated oxidative damage to de novo synthesized ApoA-1 in type 1 diabetes. Diabetes 59: 2366-2374, 2010.

Henderson GC, Fattor JA, Krauss RM, Faghihnia N, Luke-Zeitoun M, Brooks GA. Plasma triglyceride concentrations are rapidly reduced following individual bouts of endurance exercise in women. European Journal of Applied Physiology 109: 721-730, 2010.

Henderson GC, Nadeau D, Horton ES, Nair KS. Effects of adiposity and 30 days of caloric restriction upon protein metabolism in moderately and severely obese women. Obesity 18: 1135-1142, 2010.

Henderson GC, Dhatariya K, Ford GC, Klaus KA, Basu R, Rizza RA, Jensen MD, Khosla S, O’Brien P, Nair KS. Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB Journal 23: 631-641, 2009.

Henderson GC, Fattor JA, Horning MA, Faghihnia N, Johnson ML, Luke-Zeitoun M, Brooks GA. Glucoregulation is more precise in women than men during postexercise recovery. American Journal of Clinical Nutrition 87: 1686-1694, 2008.

Henderson GC, Fattor JA, Horning MA, Faghihnia N, Johnson ML, Mau TL, Luke-Zeitoun M, Brooks GA. Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period. Journal of Physiology 584: 963-981, 2007.

Henderson GC, Fattor JA, Horning MA, Faghihnia N, Luke-Zeitoun M, Brooks GA. Retention of intravenously infused [13C]bicarbonate is transiently increased during recovery from hard exercise. Journal of Applied Physiology 103: 1604-1612, 2007.

Friedlander AL, Braun B, Pollack M, MacDonald JR, Fulco CS, Muza SR, Rock PB, Henderson GC, Horning MA, Brooks GA, Hoffman AR, Cymerman A. Three weeks of caloric restriction alters protein metabolism in normal-weight, young men. American Journal of Physiology: Endocrinology and Metabolism 289: E446-455, 2005.

Kuo CC, Fattor JA, Henderson GC, and Brooks GA. Lipid oxidation in fit young adults during postexercise recovery. Journal of Applied Physiology 99: 349-356, 2005.

Henderson GC, Horning MA, Lehman SL, Wolfel EE, Bergman BC, and Brooks GA. Pyruvate shuttling during rest and exercise before and after endurance training in men. Journal of Applied Physiology 97: 317-325, 2004.

 headshot of Greg Henderson
Assistant Professor

Office: STONE 208
Address: 700 West State Street
West Lafayette, IN 47907
Phone: 496-9462

Department of Nutrition Science, 700 W. State Street, West Lafayette, IN 47907-2059 (765) 494-8228, Fax: (765) 494-0674

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