Keith M. Stantz, Ph.D.

Research Interests / Training Areas

  • Physiological Imaging using Dynamic Contrast-Enhanced Imaging
    • Quantify intra-tumor physiology
    • Influence of tumor angiogenic phenotype in cancer progression and metastasis
    • Investigate response to anti-angiogenic and radiation therapies
  • Development of Thermoacoustic CT Imaging
    • Molecular Imaging using Photoacoustic CT-spectroscopy (PCT-S)
    • 3D Dosimetric Imaging of Particle Beams using Radiation-induced Acoustic CT (RACT)
  • Modeling of Tumor Biology
    • Multi-parametric image fusion of hypoxia
    • Explore the role hypoxia plays on cancer stem cell prevalence and on the immune response to radiation therapy

Biography

Dr. Keith Stantz is a Professor of Imaging Sciences and Medical Physics within the School of Health Sciences at Purdue University. Dr. Stantz obtained a B.S. degree from Valparaiso University in ECE and Physics (1988); an M.S. degree in Physics from Michigan State University (East Lansing, MI); and a PhD from Indiana University (Bloomington, IN) in particle physics, where he was part of the MEGA research team investigating rare muon decay at Los Alamos National Laboratory. As a Project and Research Scientist at two small companies and IUSM, he developed CT, optical and thermoacoustic imaging instrumentation and methods. As a faculty at Purdue, his research continues to focus on developing diagnostic imaging in the treatment of cancer, and the training of students in the Medical Physics and the field of Imaging Sciences.

Recent / RepresentativePublications

Miles D, Cao N, Sandison G, Stewart RD, Moffitt G, Pulliam T, Parvathaneni U, Goff P, Nghiem P, Stantz K. Differential effects of high versus low LET radiation on type-I interferon (IFNb) response. (in preparation)

Sick JT, Rancilio NJ, Fulkerson CV, Plantenga JM, Knapp DW, Stantz KM. An ultrasound based platform for image-guided radiotherapy in canine bladder patients. Physics and Imaging in Radiation Oncology 12:10-16, 2019.

Miles D, Stantz K. Photoacoustic CT to Characterize the Effects of Antiangiogenic Drugs On Acute and Chronic Hypoxia (WE-FG-303-7). Medical Physics 46(6): e468-e469, 2019.

Klem M and Stantz K. Feasibility of a prototype RACT scanner to Image Proton Beam in the Brain (SU-E-202-1). Medical Physics 45(6): 2722, 2018.

Castanares M, Chavali B, Meyer C, Babur M, Little RA, Cheung S, Watson Y, Steart JA, Falcon BL, Williams K, Plowman GD, Stantz KM, O’Connor JP, Chintharlapalli S, Collins EC. Investigations on the temporal evolution of antivascular effects induced by anti-angiogenic therapy using multiple imaging modalities in an orthotopic syngeneic mouse model (2733550).. Mol Imaging Biol 19 (Suppl 1):S190, 2017.

Lee C-W and Stantz KM. Development of a mathematical model to estimate intra-tumor oxygen concentrations through multi-parametric imaging. BioMedical Engineering OnLine 15:article number: 114, 2016.

Stantz K, Alsanea F, Moskvin V. Feasibility of RACT for 3D dose measurement and range verification in a water phantom. Med Phys 42(2):937-946, 2015.

Cao N, Cao M, Chin-Sinex H, Mendonca M, Ko S-C, Stantz KM. Monitoring the Effects of Anti-angiogenesis on the Radiation Sensitivity of Pancreatic Cancer Xenografts Using Dynamic Contrast-Enhanced CT. Int J of Radiat Oncol Biol Phys 88(2):412-8, 2014.

Choi M-R, Bardhan R, Stanton-Maxey KJ, Badve S, Nakashatri H, Stantz KM, Cao N, Halas NJ, Clare SE, Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan Horse. Cancer Nanotechnology 3: 47-54, 2012.

Stantz KM, Cao M, Liang Y, Miller KD. Monitoring the Longitudinal Intra-Tumor Physiology Impulse Response to VEGFR2 Blockade in Breast Tumors Using DCE-CT. Molecular Imaging and Biology3(6):1183-95, 2011.

Curriculum Vitae

Click here for a full CV for Keith M. Stantz. (an Adobe Acrobat file)

Google Scholar

Keith M. Stantz

Associate Professor of Health Sciences
Assistant Professor of Radiology, Indiana University School of Medicine

Phone: 765-496-1874
Fax: 765-496-1377
E-mail: kstantz@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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