Jonathan Shannahan, Ph.D.

Research Interests/Training Areas

• Susceptible Subpopulations to Toxic Insults
• Role of the Nanoparticle-Biocorona in Cellular Interactions
• Inflammatory Resolution Signaling
• Oral Health Effects of Electronic Nicotine Delivery Systems
• Responses of the Immune System to Engineered Nanomaterials
• Cured-In-Place Pipe Emissions and Health Effects
• -Omics Approaches

Biography

Jonathan Shannahan is an Assistant Professor in the School of Health Sciences at Purdue University in West Lafayette, IN.  He received his B.S. in Chemistry from North Carolina State University and a Ph.D. in Toxicology from the University of North Carolina Chapel Hill.  He did his post-doctoral work at East Carolina University and the University of Colorado Anschutz Medical Campus.  The Shannahan laboratory mechanistically investigates toxicity associated with environmental and occupational exposures utilizing both in vitro and in vivo models.  His research team is especially interested in understanding how prevalent underlying diseases influence responses to toxic exposures. These studies evaluate immune, cardiovascular, and pulmonary toxicity associated with engineered nanomaterial exposures.  Specifically examining the role of surface associated physiological macromolecules, and how their addition alters nanomaterial cellular interactions, immune responses, and disease progression. The Shannahan laboratory also examines disrupted inflammatory resolution signaling following exposures utilizing novel lipidomic approaches. These deficits in inflammatory resolution are likely targets for interventional approaches. The Shannahan Laboratory also has ongoing projects evaluating toxicity related to the use of electronic nicotine delivery systems as well as the emissions produced during the repair of underground pipes. Overall, the goals of these studies are to 1) elucidate mechanisms of toxicity in susceptible subpopulations in order to mitigate adverse public health effects; 2) determine potential biomarkers and interventional strategies to mitigate toxicity; 3) utilize novel and emerging technologies to assess mechanisms of toxicity.

Recent Publications

Alqahtani S, Xia L, Jannasch A, Ferreira C, Franco J, Shannahan J. Disruption of pulmonary resolution mediators contribute to exacerbated silver nanoparticle-induced acute inflammation in a metabolic syndrome mouse model. Toxicology and Applied Pharmacology 2021

Kobos L, Ferreira C, Sobreira T, Rajwa B, Shannahan J. A novel experimental workflow to determine the impact of storage parameters on the mass spectrometric profiling and assessment of representative phosphatidylethanolamine lipids in mouse tissues. Analytical and Bioanalytical Chemistry 2021

Alqahtani S, Cooper B, Spears C, Wright C, Shannahan J. Electronic nicotine delivery system-induced alterations in oral health via saliva assessment. Experimental Biology and Medicine 2020

Alqahtani S, Kobos L, Xia L, Ferreira C, Franco J, Du X, Shannahan J. Exacerbation of nanoparticle-induced acute pulmonary inflammation in a mouse model of metabolic syndrome. Frontiers in Immunology 2020

Kobos L, Alqahtani S, Ferreira C, Aryal U, Hedrick V, Sobreira T, Shannahan J. An integrative proteomic/lipidomic analysis of the gold nanoparticle biocorona in healthy and obese conditions. Applied In Vitro Toxicology 2019

Kobos L, Teimouri Sendesi S, Whelton A, Boor B, Howarter J, Shannahan J. In vitro toxicity assessment of emitted materials collected during the manufacture of water pipe plastic linings. Inhalation Toxicology 2019