Linda H. Nie, PhD.

Research Interests / Training Areas

  • Development, Validation, and Application of Non-invasive Neutron Activation Analysis Technology to Quantify Metals and Trace Elements in Bone and Soft Tissue In Vivo.

    o Quantification of manganese (Mn) and aluminum (Al) in bone, and association between Mn/Al exposure and neurodegeneration

    o Quantification of sodium (Na) and potassium (K) in bone and soft tissue, Na/K intake, storage, biokinetics, and hypertension and cardiovascular diseases (CVD)

    o Quantification of magnesium (Mg) in bone, and association between Mg exposure and varies health outcomes

    o Quantification of other metals and trace elements in human tissues and small animals in vivo, and applications in biology and health sciences

    o Health effect of exposure to metal mixtures

  • Development, Validation, and Application of a Non-invasive X-ray Fluorescence (XRF) Technology to Quantify Metals and Trace Elements in Bone, Toenail, and Skin In Vivo.

    o Quantification of lead (Pb) and gadolinium (Gd) in bone using an advanced Cd-109 induced k-x-ray fluorescence (KXRF) system

    o Quantification of Pb and strontium (Sr) in bone, and manganese (Mn), mercury (Hg), zinc (Zn), and selenium (Se) in toenail using a portable XRF device

    o Quantification of arsenic (As) in skin using a portable XRF device

    o Quantification of metals in bone using a portable KXRF system

    o Pb exposure and neurodegeneration (Alzheimer’s Disease and Parkinson’s Disease); Pb exposure and neurodevelopmental effect

    o Sr exposure and bone diseases

    o Health effects of exposure to metals individually and combined

  • Development and Application of Synchrotron X-ray Technologies to Study Metal and Human Health.

    o Synchrotron micro XRF to map metals in bone, tooth, and brain tissues

    o Synchrotron x-ray absorption near edge structure (XANES) to determine elemental speciation

    o Synchrotron micro- and nano- tomography

    o Application of the synchrotron x-ray technologies in metal toxicology and health, neurodegeneration, and mechanism studies

  • Development and Validation of Other Neutron Technologies in Medicine.

    o Associated particle elemental imaging (APEI) technology to determine elemental distribution and diagnose diseases associated with elemental alteration at an early stage

    o Neutron generator based boron neutron capture therapy (BNCT) system for cancer treatment

  • Biological Effects of Radiation Exposure, and Combined Exposure of Metal and Radiation.

  • General Nuclear Physics and Instrumentation Development in Interdisciplinary and Multidisciplinary fields


Linda H. Nie is an Associate Professor in School of Health Sciences at Purdue University in West Lafayette, Indiana. She received her B.S. in Physics from Zhongnan University of Technology in China, a M.S. and a Ph.D. in Medical Physics from McMaster University in Canada. She did her postdoctoral training in Nuclear Instrumentation, Exposure Assessment, and Epidemiology at Harvard University before joining Purdue in 2009. She teaches courses in Medical Physics, Health Physics, and Radiation Sciences. She and her husband, Baozeng Zhang, have three children.

Recent Publications

Zhang X, Specht AJ, Wells E, Weisskopf MG, Weuve J, Nie LH* (2020). Evaluation of a Portable XRF Device for In Vivo Quantification of Lead in Bone among a US Population. Sci Total Environ, Epub ahead of print:

Specht AJ, Weisskopf M, Nie LH*. Childhood Lead Biokinetics and Associations with Age among a Group of Lead-poisoned Children in China. J Expo, Sci Environ Epidemiol. 29(2019)416-423

Lin Y, Huang L, Specht AJ, Xu J*, Yan C, Geng H, Shen X, Nie LH*, Hu H (2019). The Association of Bone Lead and Blood Lead with Child Attention-deficit-hyperactivity- disorder-like Behavior. Sci Total Environ. 659(2019)161-167

Coyne MD, Lobene A, Neumann C, Lachcik P, Weaver CM, Nie LH*. Determination of Bone Sodium (Na) and Na Exchange in Pig Leg using In Vivo Neutron Activation Analysis (IVNAA), Physiol Meas. 40(2019)075009, doi: 10.1088/1361-6579/ab2ba5

Rolle-McFarland D, Liu Y, Zhou J, Mostafaei F, Zhou Y, Li Y, Fan Q, Zheng W, Nie LH*, Wells E*. The Association between Bone, Fingernail, and Blood Manganese with Cognitive and Olfactory Function in Chinese Workers. Sci Total Environ. 666(2019) 1003-1010

Liu Y, Rolle-McFarland D, Mostafaei F, Zhou Y, Li Y, Zheng W, Wells EM*, Nie LH*. In Vivo Neutron Activation Analysis (IVNAA) of Bone Manganese (Mn) in Workers, Physiological Measurement, 39(2018)035003

Zhang X, Specht AJ, Weisskopf MG, Weuve J, Nie LH*. Quantification of Manganese and Mercury in Toenail In Vivo Using Portable X-ray Fluorescence (XRF). Biomarkers, 23(2018)154-160

Abel MR2 and Nie LH*. Monte Carlo Simulations of Elemental Imaging using the Neutron Associated Particle Technique. Medical Physics, 45(2018)1631-1644.

Hsieh M2, Liu Y2, Mostafaei F3, Poulson J, Nie LH*. A Feasibility Study of a Deuterium-deuterium Neutron Generator-based Boron Neutron Capture Therapy System for Treatment of Brain Tumors. Medical Physics, 44(2017)637-643

Wang Y2, Specht A2, Liu Y2, Finney L, Maxey E, Zheng W, Weisskopf M, Nie LH*. Micro-distribution of Lead in Human Teeth Using Synchrotron m-XRF. X-ray Spectrometry, 46(2017)19-26

NCBI Weblink to My Bibliography


Huiling (Linda) Nie

Associate Professor

Phone: 765-494-2625
Fax:  765-496-1377


Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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