Shuang Liu, Ph.D.

Research Interests / Training Areas

  • Research Interest: Radiochemistry and Radiopharmaceutical Development

    o Development of novel radiotracers for myocardial perfusion imaging

    o Fundamental coordination chemistry of radiopharmaceuticals.

Biography

Dr. Liu graduated with his Ph.D. in 1990 from Memorial University of Newfoundland, Canada.  He spent the next three years as a postdoctoral fellow at the University of British Columbia.  After nine years of industrial research at DuPont Medical Imaging Division (now Lantheus Medical Imaging Inc.), he joined Purdue University as Associate Professor in 2002, and then became a full professor in School of Health Sciences.  Dr. Liu is the leader in using radiolabeled multimeric RGD peptides as radiotracers for non-invasive imaging of integrin αvβ3 expression in the rapidly growing and metastatic tumors.  After evaluating >30 radiotracers in different tumor-bearing animal models, 99mTc-3P-RGD2 has been selected for clinical evaluation. Clinical data clearly indicate that 99mTc-3P-RGD2 is very useful for the diagnosis of primary tumors (breast, esophagus, head & neck, lung, and melanoma) and small metastatic lesions in breast cancer patients.

Recent / Representative Publications

Xi, X-Y.; Wang, L.; Hsu, B.; Zhao, Z. Q.; Liu, S.; and Fang, W. 99mTc-3SPboroxime: a neutral 99mTc(III) radiotracer with high heart uptake and Long myocardial retention. J. Nucl. Cardiol. 2020. http://link.springer.com/10.1007/s12350-020-02087-3

2. Fang, W.; and Liu, S. New 99mTc Radiotracers for Myocardial Perfusion Imaging by SPECT. Current Radiopharmaceuticals 2019, 12: 171-186.

3. Liu, M.; Yang, Y.; Wei Fang.; and Liu, S. Sulfonyl-containing boronate caps for novel 99mTc(III) complexes [99mTcCl(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime) with favorable properties for myocardial perfusion imaging. J. Med. Chem. 2018, 61: 319−32810.

4. Liu, M.; Zhao, Z. Q.; Fang, W.; and Liu, S. A novel approach for in vivo 99mTc-labeling of red blood cells: evaluation of 99mTc-4SAboroxime as a blood pool radiotracer. Biocoj. Chem. 2017, 28:2998 – 3006.

5. Liu, M.; and Liu, S. 99mTc-3Cboroxime: A novel 99mTc(III) complex [99mTcCl(CDO)(CDOH)2B-3C] (CDOH2 = Cyclohexanedione Dioxime; 3C-B(OH)2 = 3-(carbamoylphenyl)boronic acid) with high heart uptake and long myocardial retention. Dalton Transactions. 2017, 46: 14509 – 14518.

Shuang Liu, Ph.D.

Professor of Health Sciences

Phone: 765-494-0236
Fax: 765-496-1377
E-mail: liu100@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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