Jason Cannon, Ph.D.

Research Interests/Training Areas

  • Dietary toxins and neurological disease
  • Environmentally-induced autophagy disruptions
  • Gene-environment interactions in Parkinson’s disease


Jason Cannon is an Associate Professor of Toxicology in the School of Health Sciences at Purdue University in West Lafayette. He received his B.S. in Physiology from Michigan State University, his Ph.D. in Toxicology from the University of Michigan, and was a postdoctoral fellow at the Pittsburgh Institute of Neurodegenerative Diseases at the University of Pittsburgh. He teaches courses in analytical, pathological, and biochemical toxicology and performs mechanistic research on the environmental exposures and neurological disease. Further, his group aims to identify and test novel therapeutic strategies. His research group is particularly interested in the following topics related neurodegeneration: 1) Neurotoxicity of heterocyclic amines, which are compounds formed during high temperature cooking; 2) How environmental insults may disrupt autophagy and lead to neuronal cell death; 3) How specific genetic factors can increase sensitivity to environmental insults and resultant neurotoxicity. The lab utilizes neurobehavioral, biochemical, and histological techniques to address these topics.

Recent Publications

Wise, J. P., Jr., Price, C. G., Amaro, J. A., Cannon, J. R., (2018). Autophagy Disruptions Associated With Altered Optineurin Expression in Extranigral Regions in a Rotenone Model of Parkinson's Disease. Front Neurosci. 12, 289.
Cruz-Hernandez, A., Agim, Z. S., Montenegro, P. C., McCabe, G. P., Rochet, J. C., and Cannon, J. R. (2018). Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology 65, 68-84, 10.1016/j.neuro.2018.01.009.
Agim, Z. S., and Cannon, J. R. (2018). Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure. Toxicology letters 287, 31-41, 10.1016/j.toxlet.2018.01.017.
Sammi, S. R., Agim, Z. S., and Cannon, J. R. (2018). From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology 161(2), 335-348, 10.1093/toxsci/kfx223.
Wise, J. P., Jr., and Cannon, J. (2016). From the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease Models. Toxicological sciences : an official journal of the Society of Toxicology 153(2), 372-81, 10.1093/toxsci/kfw133.
Griggs, A. M., Agim, Z. S., Mishra, V. R., Tambe, M. A., Director-Myska, A. E., Turteltaub, K. W., McCabe, G. P., Rochet, J. C., and Cannon, J. R. (2014). 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro. Toxicological sciences : an official journal of the Society of Toxicology 140(1), 179-89, 10.1093/toxsci/kfu060.

Full publication list: http://scholar.google.com/citations?user=l3f_ixcAAAAJ&hl=en

Purdue Interdisciplinary Life Science Program (PULSe) link:

Jason Cannon

Associate Professor of Toxicology

Faculty Associate, Center on Aging and Life Course

Phone: 765-494-0794
Fax: 765-496-1377
E-mail: cannonjr@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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