Jason Cannon, Ph.D.

Research Interests/Training Areas

  • Neurotoxic exposures and neurological disease
    • Identification of toxicants/toxins that may influence the development of Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease
    • Identification of neurotoxic mechanisms of action relative to adverse neurological outcomes
    • Focus on neurotoxicity of heterocyclic aromatic amines (dietary toxins), per- and polyfluoroalkyl substances (PFAS), and pesticides
  • Gene-environment interactions in neurodegeneration
    • Elucidation of specific genetic events that modulate the magnitude of neurotoxicity
    • Creation and utilization of new models to study neurodegeneration stemming from gene-environment interactions
  • Comparative biology of neurodegeneration
    • Determination of similarities and differences of species-specific responses to neurotoxic insults to advance understanding of pathogenic mechanisms
    • Creation, validation, and utilization of models that offer higher translational value to study environmentally induced neurodegeneration


Jason Cannon is an Associate Professor of Toxicology in the School of Health Sciences at Purdue University in West Lafayette. He received his B.S. in Physiology from Michigan State University, his Ph.D. in Toxicology from the University of Michigan, and was a postdoctoral fellow at the Pittsburgh Institute of Neurodegenerative Diseases at the University of Pittsburgh. He teaches courses in analytical, pathological, and biochemical toxicology and performs mechanistic research on the environmental exposures and neurological disease, along with major leadership roles in multiple graduate programs. His group aims to identify and test novel therapeutic strategies. The lab utilizes neurobehavioral, neurochemical, and neuropathology techniques to address Research Interests/Training Areas.

Recent Publications

Lawana, V., Um, S. Y., Rochet, J. C., Turesky, R. J., Shannahan, J. H., and Cannon, J. R. (2020). Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology 173(1), 171-188

Syeda, T., Foguth, R. M., Llewellyn, E., and Cannon, J. R. (2020). PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease. Toxicology 437, 152436.

Foguth, R. M., Hoskins, T. D., Clark, G. C., Nelson, M., Flynn, R. W., de Perre, C., Hoverman, J. T., Lee, L. S., Sepulveda, M. S., and Cannon, J. R. (2020). Single and mixture per- and polyfluoroalkyl substances accumulate in developing Northern leopard frog brains and produce complex neurotransmission alterations. Neurotoxicol Teratol doi: 10.1016/j.ntt.2020.106907, 106907.

Sammi, S. R., Foguth, R. M., Nieves, C. S., De Perre, C., Wipf, P., McMurray, C. T., Lee, L. S., and Cannon, J. R. (2019). Perfluorooctane Sulfonate (PFOS) Produces Dopaminergic Neuropathology in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology 172(2), 417-434, 10.1093/toxsci/kfz191.

Wise, J. P., Jr., Price, C. G., Amaro, J. A., Cannon, J. R., (2018). Autophagy Disruptions Associated With Altered Optineurin Expression in Extranigral Regions in a Rotenone Model of Parkinson's Disease. Front Neurosci. 12, 289.

Full publication list: http://scholar.google.com/citations?user=l3f_ixcAAAAJ&hl=en

Purdue Interdisciplinary Life Science Program (PULSe) link: 






Associate Professor of Toxicology

Courtesy Faculty, Department of Public Health

Faculty Associate, Purdue Institute for Integrative Neuroscience 

Faculty Associate, Center on Aging and Life Course

Phone: 765-494-0794
Fax: 765-496-1377
E-mail: cannonjr@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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