Aaron Bowman, Ph.D.

Research Interests/Training Areas

  • Gene x Environment Interactions in Neurological Disease
  • Metal Neurotoxicity (manganese, methylmercury, copper)
  • Huntington’s Disease, Parkinson’s Disease, Alzheimer’s Disease, Neurodevelopmental disorders

Biography 

Aaron Bowman is Professor and Head of the School of Health Sciences and member of the Purdue Institute for Integrative Neuroscience (PIIN). His lab utilizes a combined approach of molecular genetics, pharmacology, biochemistry, cell and developmental biology to understand the role of gene-environment interactions between metal exposure and neurodegenerative diseases. The lab employs a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal cultures and mouse models. The lab aims to define mechanisms of neuronal dysfunction and understand the basis of selective neuropathology, by characterizing the molecular function of disease genes and their interaction with environmental toxicants under both normal and pathological conditions. The lab has been applying iPSC technology to neurotoxicity research for 10+ years, and has established protocols to generate iPSC lines and differentiate them down forebrain, striatal and midbrain neural lineages. The lab applies toxicological and functional approaches, in addition to novel high-throughput screening and high-content approaches. The long-term goal is to use a personalized medicine approach to investigate patient-specific toxicant vulnerabilities and develop neuroprotective strategies that mitigate neurological diseases with environmental etiologies.

Recent Publications

Neely MD, Davison CA, Aschner M, Bowman AB. From the cover: Manganese and rotenone-induced oxidative stress signatures differ in iPSC-derived human dopamine neurons. 2017. Toxicological Sciences. 159(2):366-379. PMCID in progress

Bryan MR, Uhouse MA, Nordham KD, Joshi P, Rose DIR, O'Brien MT, Aschner A, Bowman AB. Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line. 2017. NeuroToxicology. 159(2):366-379. 

Isaacs D, Claassen D, Bowman AB, Hedera P. Phenotypic Discordance in Siblings with Identical Compound Heterozygous PARK2 Mutations. 2017. Brain Science. 7(7). pii: E71. PMID: 28672806

Hollmann EK, Bailey AK, Potharazu AV, Neely MD, Bowman AB, Lippmann ES. Accelerated differentiation of human induced pluripotent stem cells to blood-brain barrier endothelial cells. 2017. Fluids Barriers CNS. 14(1):9. PMC5390351

Bichell TJ, Wegrzynowicz M, Grace Tipps K, Bradley EM, Uhouse MA, Bryan M, Horning K, Fisher N, Dudek K, Halbesma T, Umashanker P, Stubbs AD, Holt HK, Kwakye GF, Tidball AM, Colbran RJ, Aschner M, Diana Neely M, Di Pardo A, Maglione V, Osmand A, Bowman AB. Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model. 2017. Biochim Biophys Acta (BBA) - Molecular Basis of Disease. 1863(6):1596-1604. PMC5515276

Brown JA, Codreanu SG, Shi M, Sherrod SD, Markov DA, Neely MD, Britt CM, Hoilett OS, Reiserer RS, Samson PC, McCawley LJ, Webb DJ, Bowman AB, McLean JA, Wikswo JP. Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit. 2016. Journal of Neuroinflammation. 13(1):306. PMC5153753

Ruszkiewicz JA, Bowman AB, Farina M, Rocha JB, Aschner M. Sex- and structure-specific differences in antioxidant responses to methylmercury during early development. 2016. Neurotoxicology. 56:118-126..

Tidball AM, Neely MD, Chamberlin R, Aboud AA, Kumar KK, Han B, Bryan MR, Aschner M, Ess KC, Bowman AB. Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells. 2016. PLoS One. 11(3): e0150372. PMC4794230.

 

All peer reviewed publications https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40688189/?sort=date&direction=descending 

Purdue Institute for Integrative Neuroscience (PIIN) https://www.purdue.edu/discoverypark/institute-for-integrative-neuroscience/faculty/index.php 

PULSe http://www.purdue.edu/gradschool/pulse/groups/integrative-neuroscience.html


Aaron Bowman
Professor and Head

Phone: 765-494-2684
Fax: 765-496-1377
E-mail: bowma117@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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