Bruno Roseguini

Research Interests:

My primary research focus is to elucidate the mechanistic basis underlying exercise intolerance in peripheral artery disease (PAD) and explore novel therapeutic interventions to restore vascular and skeletal muscle function and improve functional capacity in patients with this condition. We utilize a translational approach with experiments in rodent models as well as in patients with symptomatic PAD. We are currently conducting a series of studies to investigate the acute and long-term impact of heat therapy on the vasculature and on skeletal muscle of patients with PAD as well as in healthy young volunteers. Heat therapy is an emerging non-invasive therapeutic tool that has been shown to overcome some of the barriers associated with current therapies for PAD. Heat therapy is particularly appealing for patients with PAD because it is portable, easy to use and amenable for application in the home setting, thus eliminating the need for patient supervision as well the frequent travelling to rehabilitation facilities. We recently examined the impact of repeated exposure to heat therapy in a model of PAD produced by ligation of the femoral artery in mice. Exposure to heat therapy at 37ºC and 39ºC improved force development of the isolated soleus muscle.  In healthy young individuals, we demonstrated that exposure to heat therapy promotes marked increases in skin and leg blood flow and enhances the expression in skeletal muscle of key genes involved in vascular and skeletal muscle growth, including vascular endothelial growth factor. More recently, we documented that repeated applications of leg heat therapy following muscle damage accelerates functional recovery in healthy individuals.

In The News:

These warming 'space pants' use technology to help people with chronic pain (April 1, 2019)

Space technology can help patients take a ‘giant leap’ around their neighborhood (March 21, 2019)

Purdue professor hopes space pants can help patients with a painful leg disease (March 29, 2017)


B.S. in Physical Therapy, Londrina State University, Brazil, 2004
M.S. in Cardiovascular Sciences, Federal University of Rio Grande do Sul, Brazil, 2006
Ph.D. in Biomedical Sciences, University of Missouri, 2011

Selected Publications:

  • Kim K, Reid BA, Ro B, Casey CA, Song Q, Kuang S, Roseguini BT. Heat therapy improves soleus muscle force in a model of ischemia-induced muscle damage. J Appl Physiol. 2019 May 30
  • Kim K, Kuang S, Song Q, Gavin TP, Roseguini BT. Impact of heat therapy on recovery following eccentric exercise in humans.  J Appl Physiol. 2019 Apr 1;126(4):965-976.
  • Neff D, Kuhlenhoelter AM, Lin C, Wong BJ, Motaganahalli RL, Roseguini BT. Thermotherapy reduces blood pressure and circulating endothelin-1 concentration and enhances leg blood flow in patients with symptomatic peripheral artery disease. Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R392-400.
  • Kuhlenhoelter AM, Kim K, Neff D, Nie Y, Blaize AN, Wong BJ, Kuang S, Stout J, Song Q, Gavin TP, Roseguini BT. Heat therapy promotes the expression of angiogenic regulators in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R377-91.
  • da Silva ND Jr, Roseguini BT, Chehuen M, Fernandes T, Mota GF, Martin PK, Han SW, Forjaz CL, Wolosker N, de Oliveira EM. Effects of oral N-acetylcysteine on walking capacity, leg reactive hyperemia, and inflammatory and angiogenic mediators in patients with intermittent claudication. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H897-905.
  • Roseguini BT, Silva LM, Polotow TG, Barros M.P., Souccar C., Han, S.W. Effects of N-acetylcysteine on skeletal muscle structure and function in a mice model of peripheral arterial insufficiency. J Vasc Surg. 2015 Mar;61(3):777-86.
  • Roseguini BT, Hirai DM, Alencar MC, Ramos RP, Silva BM, Wolosker N, Neder JA, Nery LE. Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication. Am J Physiol Regul Integr Physiol. 2014 Aug 15;307(4):R396-404.

Bruno Roseguini

Associate Professor

Lambert, Room 08A
Phone: (765) 496-2612
Fax: (765) 496-1239

Exercise Physiology

Center on Aging and Life Course

Health & Kinesiology, 800 W. Stadium Ave., West Lafayette, IN 47907, PH:(765) 494-3170, Fax: (765) 496-1239

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