Bruno Roseguini

Research Interests:

My primary research focus is to elucidate the mechanistic basis underlying exercise intolerance in peripheral artery disease (PAD) and explore novel therapeutic interventions to restore vascular and skeletal muscle function and improve functional capacity in patients with this condition. We utilize a translational approach with experiments in rodent models as well as in patients with symptomatic PAD.


B.S. in Physical Therapy, Londrina State University, Brazil, 2004
M.S. in Cardiovascular Sciences, Federal University of Rio Grande do Sul, Brazil, 2006
Ph.D. in Biomedical Sciences, University of Missouri, 2011

Selected Publications:

  • Roseguini B.T., Silva LM, Polotow TG, Barros M.P., Souccar C., Han, S.W. Effects of N-acetylcysteine on skeletal muscle structure and function in a mice model of peripheral arterial insufficiency. J Vasc Surg. 2015 Mar;61(3):777-86.
  • Roseguini BT, Hirai DM, Alencar MC, Ramos RP, Silva BM, Wolosker N, Neder JA, Nery LE. Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication. Am J Physiol Regul Integr Physiol. 2014 Aug 15;307(4):R396-404.
  • Sheldon R, Roseguini B. T., Laughlin M, Newcomer S.C.New Insights into the Physiologic Basis for Intermittent Pneumatic Limb Compression as a Therapeutic Strategy for Peripheral Artery Disease. J Vasc Surg 2013 Dec;58(6):1688-96.
  • Sheldon RD, Roseguini BT, Thyfault JP, Crist BD, Laughlin MH, Newcomer SC.Acute impact of intermittent pneumatic leg compression frequency on limb hemodynamics, vascular function, and skeletal muscle gene expression in humans. J Appl Physiol. 2012 Jun;112(12):2099-109.
  • Roseguini BT, Arce-Esquivel AA, Newcomer SC, Yanh HT, Terjung RL, Laughlin MH. Intermittent pneumatic leg compressions enhance muscle performance and blood flow in a model of peripheral arterial insufficiency. J Appl Physiol 112(9):1556-63, 2012
  • Roseguini BT, Arce-Esquivel AA, Newcomer SC, Laughlin MH. Impact of a single session of intermittent pneumatic leg compressions on skeletal muscle and isolated artery gene expression in rats. Am J Physiol Regul Integr Comp Physiol. 2011 301(6):R1658-68.
  • Roseguini BT, Sheldon R, Stroup A, Bell JW, Maurer D, Crist BD, Laughlin MH, Newcomer SC. Impact of chronic intermittent external compressions on forearm blood flow capacity in humans.Eur J Appl Physiol. 2011 Mar;111(3):509-19.
  • Roseguini BT, Mehmet Soylu S, Whyte JJ, Yang HT, Newcomer S, Laughlin MH.Intermittent pneumatic leg compressions acutely upregulate VEGF and MCP-1 expression in skeletal muscle.Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1991-2000.
  • Roseguini BT, Davis MJ, Harold Laughlin M. Rapid vasodilation in isolated skeletal muscle arterioles: impact of branch order. Microcirculation. 2010 Feb;17(2):83-93.
  • Laughlin MH, Roseguini B. Mechanisms for exercise training-induced increases in skeletal muscle blood flow capacity: differences with interval sprint training versus aerobic endurance training. J Physiol Pharmacol. 2008 Dec;59 Suppl 7:71-88.
  • Chiappa GR, Roseguini BT, Vieira PJ, Alves CN, Tavares A, Winkelmann ER, Ferlin EL, Stein R, Ribeiro JP. Inspiratory muscle training improves blood flow to resting and exercising limbs in patients with chronic heart failure. J Am Coll Cardiol. 2008 Apr 29;51(17):1663-71.
  • Roseguini BT, Alves CN, Chiappa GR, Stein R, Knorst MM, Ribeiro JP. Attenuation of muscle metaboreflex in chronic obstructive pulmonary disease. Med Sci Sports Exerc. 2008 Jan;40(1):9-14.
  • Chiappa GR, Roseguini BT, Alves CN, Ferlin EL, Neder JA, Ribeiro JP. Blood lactate during recovery from intense exercise: impact of inspiratory loading. Med Sci Sports Exerc.2008 Jan;40(1):111-6.
  • Roseguini BT, Alves CN, Chiappa GR, Stein R, Ribeiro JP. Muscle metaboreflex contribution to resting limb haemodynamic control is preserved in older subjects.

Bruno Roseguini

Assistant Professor

Lambert, Room 08A
Phone: (765) 496-2612
Fax: (765) 496-1239

Exercise Physiology

Center on Aging and Life Course

Health & Kinesiology, 800 W. Stadium Ave., West Lafayette, IN 47907, PH:(765) 494-3170, Fax: (765) 496-1239

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