Daniel Hirai

Research Interests

My research focuses on the (dys)regulation of oxygen transport and utilization at the muscle microcirculatory level with an emphasis on exercise tolerance in health and disease. We utilize a translational approach with investigations in pre-clinical rodent models and patients to identify therapeutic targets and improve microvascular and muscle function with rehabilitation and pharmacological/non-pharmacological interventions. 

Education

Ph.D., Physiology, Kansas State University, 2012
M.S., Kinesiology, Londrina State University, Brazil, 2007
B.S., Physical Therapy, Londrina State University, Brazil, 2004

Selected Journal Publications

For a complete list of publications please go to http://bit.ly/Hirai-publications

Hirai DM, Craig JC, Colburn TD, Eshima H, Kano Y, Musch TI, Poole DC. Skeletal muscle interstitial PO2 kinetics during recovery from contractions. J Appl Physiol. 127:930-939, 2019.

Hirai DM, Colburn TD, Craig JC, Hotta K, Kano Y, Musch TI, Poole DC. Skeletal muscle interstitial O2 pressures: bridging the gap between the capillary and myocyte. Microcirculation 26(5):e12497, 2019.

Hirai DM, Craig JC, Colburn TD, Eshima H, Kano Y, Sexton WL, Musch TI, Poole DC. Skeletal muscle microvascular and interstitial PO2 from rest to contractions. J Physiol. 596:869-883, 2018.

Hirai DM, Copp SW, Ferguson SK, Holdsworth CT, Hageman KS, Poole DC, Musch TI. Neuronal nitric oxide synthase regulation of skeletal muscle functional hyperemia: exercise training and moderate compensated heart failure. Nitric Oxide 74:1-9, 2018.

Poole DC, Richardson RS, Haykowsky MJ, Hirai DM, Musch TI. Exercise limitations in heart failure with reduced and preserved ejection fraction. J Appl Physiol. 124:208-224, 2018.

Hirai DM, Jones JH, Zelt JT, da Silva ML, Bentley RF, Edgett BA, Gurd BJ, Tschakovsky ME, O'Donnell DE, Neder JA. Oral N-acetylcysteine and exercise tolerance in mild chronic obstructive pulmonary disease. J Appl Physiol. 122:1351-1361, 2017.

Hirai DM, Zelt JT, Jones JH, Castanhas LG, Bentley RF, Earle W, Staples P, Tschakovsky ME, McCans J, O'Donnell DE, Neder JA. Dietary nitrate supplementation and exercise tolerance in patients with heart failure with reduced ejection fraction. Am J Physiol Regul Integr Comp Physiol. 312:R13-R22, 2017.

Hirai DM, Musch TI, Poole DC. Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization. Am J Physiol Heart Circ Physiol. 309:H1419-39, 2015.

Roseguini BT, Hirai DM, Alencar MC, Ramos RP, Silva BM, Wolosker N, Neder JA, Nery LE. Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication. Am J Physiol Regul Integr Comp Physiol. 307:R396-404, 2014.

Hirai DM, Copp SW, Holdsworth CT, Ferguson SK, McCullough DJ, Behnke BJ, Musch TI, Poole DC. Skeletal muscle microvascular oxygenation dynamics in heart failure: exercise training and nitric oxide-mediated function. Am J Physiol Heart Circ Physiol. 306:H690-H698, 2014.

Hirai DM, Copp SW, Ferguson SK, Holdsworth CT, Musch TI, Poole DC. The NO donor sodium nitroprusside: evaluation of skeletal muscle vascular and metabolic dysfunction. Microvasc Res. 85:104-111, 2013.

Hirai DM, Copp SW, Ferguson SK, Holdsworth CT, McCullough DJ, Behnke BJ, Musch TI, Poole DC. Exercise training and muscle microvascular oxygenation: functional role of nitric oxide. J Appl Physiol. 113:557-565, 2012.

Hirai DM, Copp SW, Hageman KS, Poole DC, Musch TI. Aging alters the contribution of nitric oxide to regional muscle hemodynamic control at rest and during exercise in rats. J Appl Physiol. 111:989-998, 2011.

Hirai DM, Roseguini BT, Diefenthaeler F, Carpes FP, Vaz MA, Ferlin EL, Ribeiro JP, Nakamura FY. Effects of altering pedal frequency on the slow component of pulmonary V̇O2 kinetics and EMG activity. Int J Sports Med. 31:529-536, 2010.

 

 

 

Hirai Photo

Assistant Professor

Lambert, Room 201C 
Phone: (765) 494-7113
Fax: (765) 496-1239
Email:

dhirai@purdue.edu

www.purdue.edu/hhs/hk

Health & Kinesiology, 800 W. Stadium Ave., West Lafayette, IN 47907, PH:(765) 494-3170, Fax: (765) 496-1239

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