Kristine Marceau

Research Interests

Gene-environment interplay, prenatal experiences, physiological responses to stress, pubertal development, parenting and parent-child relationships, development of behavior problems and substance use

Biography

I have had a long-standing interest in understanding how biological and environmental processes work together over time in the service of identifying which types of problems children and adolescents are likely to exhibit, and which youth will develop persistent problems. My research tackles questions about the development of behavior problems and substance use across the lifespan by incorporating the integrated roles of genetics, prenatal risk, neuroendocrine development, and the family environment across childhood and adolescence. I am currently funded on a K01 career development award from the National Institute on Drug Abuse to examine biobehavioral developmental pathways and interactions among these influences for adolescent substance use. My research has a strong focus on biological underpinnings (e.g., genetics, hormones) of neurodevelopmental behavior and problems, and a strong methodological focus, including multiple models of change and developmental trajectories, and methodological considerations for repeated measures, genetic, and prenatal data.

Selected Publications 

(full list of publications)  **Undergraduate, *Graduate Student/Mentee

• Knopik, V. S., Marceau, K., Bidwell, C. L., & Rolan*, E. (in press). Prenatal substance exposure and offspring development: Does DNA methylation play a role? Neurotoxicology and Teratology.

• Marceau, K., Hottle**, S., & Yatcilla, J. K. (in press). Puberty in the last 25 years: A retrospective bibliometric analysis. Journal of Research on Adolescence.

• Marceau, K., Kirisci, L., & Tarter, R. E. (in press). Correspondence of pubertal neuroendocrine and Tanner Stage changes in boys and associations with substance use. Child Development.

• Rolan*, E., & Marceau, K. (in press). Individual and sibling characteristics: Parental differential treatment and adolescent externalizing behaviors. Journal of Youth and Adolescence.

• Marceau, K., & Abel*, E. (2018). Mechanisms of cortisol – substance use associations across the substance use progression: A theoretical synthesis and hypothesis generation through gene enrichment. Neuroscience and Biobehavioral Reviews, 92, 128-139.

• Bidwell, L. C., Marceau, K., Brick, L., Karoly, H. C., Todorov, A. A., Palmer, R. H., Heath, A. C., & Knopik V. S. (2017). Prenatal exposure effects on early adolescent substance use: A genetically-informed Bayesian approach. Journal of Studies on Alcohol and Drugs, 78, 789-94.

• Marceau, K., Bidwell, L. C., Karoly, H. C., Schettini Evans, A., Todorov, A. A., Palmer, R. H. C., Heath, A. C., & Knopik, V. S. (2017) Within-family effects of smoking during pregnancy on ADHD: the importance of phenotype. Journal of Abnormal Child Psychology, 46, 685–699.

• Marceau, K., & Jackson, K. M. (2017). Deviant peers as a mediator of pubertal timing – substance use associations: Moderating role of parental knowledge. Journal of Adolescent Health, 61, 53-20.

• Spirito, A., Hernandez, L., Marceau, K., Cancilliere, M. K., Graves, H. R., Rodriquez, A. M., & Knopik, V. S. (2017). A brief intervention for parents of adolescents with alcohol misuse: Effects on adolescents and their siblings. Journal of Substance Abuse Treatment, 77, 156-165.

• Marceau, K., De Araujo-Greecher, M., Miller, E. S., Massey, S. H., Mayes, L. C., Ganiban, J. M., Reiss, D., Shaw, D. S., Leve, L. D., & Neiderhiser, J. M. (2016). The Perinatal Risk Index: Early risks experienced by domestic adoptees in the United States. Plos One, 11: e150486.

• Marceau, K., Knopik, V. S., Neiderhiser, J. M., Lichtenstein, P., Spotts, E., Ganiban, J., & Reiss, D. (2016). Adolescent age moderates genetic and environmental influences on parent-adolescent positivity and negativity: Implications for genotype-environment correlation. Development and Psychopathology, 28, 149-66.

• Marceau, K., Palmer, R. H. C., Neiderhiser, J. M., Smith, T. F., McGeary, J. E., & Knopik, V. S. (2016). Passive rGE or developmental gene-environment cascade? An investigation of the role of xenobiotic genes in the association between smoking during pregnancy and child birthweight. Behavior Genetics, 46, 365-77.

• Short, S. J., Stalder, T., Marceau, K., Entringer, S., Moog, N. K., Shirtcliff, E. A., Wadhwa, P. D., & Buss, C. (2016). Correspondence between hair cortisol concentrations and 30-day integrated daily salivary and weekly urinary cortisol measures. Psychoneuroendocrinology, 71, 12-18.

• Marceau, K., Abar, C. C., & Jackson, K. M. (2015). Parental knowledge is a contextual amplifier of associations of pubertal maturation and substance use. Journal of Youth and Adolescence, 44, 1720-1734.

• Marceau, K., Laurent, H. K., Neiderhiser, J. M., Reiss, D., Shaw, D. S., Fisher, P., Natsuaki, M. N., & Leve, L. D. (2015). Combined influences of genes, prenatal environment, cortisol, and parenting on the development of children’s internalizing vs. externalizing problems. Behavior Genetics, 45, 268-282.

• Marceau, K., Ram, N., & Susman, E. J. (2015). Development and lability in the parent-child relationship through adolescence: Associations with pubertal timing and tempo. Journal of Research on Adolescence, 25, 474-489.

• Marceau, K., Ruttle, P. L., Shirtcliff, E. A., Hastings, P. D., Klimes-Dougan, B., & Zahn-Waxler, C. (2015). Within-person coupling of changes in cortisol, testosterone, and DHEA across the day. Developmental Psychobiology, 57(6), 654-669. doi:10.1002/dev.21173

• Marceau, K., Ruttle, P. L., Shirtcliff, E. A., Essex, M. J., & Susman, E. J. (2015). Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health. Developmental Psychobiology, 57(6), 742-768.

• Marceau, K., Zahn-Waxler, C., Shirtcliff, E. A., Schreiber, J. E., Hastings, P. D., & Klimes-Dougan, B. (2015). Adolescents’, mothers’, and fathers’ gendered coping strategies during conflict: Youth and parent influences on conflict resolution and psychopathology. Development & Psychopathology, 27, 1025-1044.

• Nederhof, E., Marceau, K., Shirtcliff, E. A., Hastings, P. D., & Oldehinkel, A. J. (2015). Autonomic and adrenocortical interactions predict mental health in late adolescence: The TRAILS study. Journal of Abnormal Child Psychology, 43, 847-861.

• Marceau, K., Narusyte, J., Ganiban, J., Spotts, E., Lichtenstein, P., Reiss, D., & Neiderhiser, J. M. (2014). Parental knowledge is an environmental influence on adolescent externalizing. Journal of Child Psychology and Psychiatry, 56, 130-137.

• Marceau, K., Shirtcliff, E. A., Hastings, P. D., Klimes-Dougan, B., Zahn-Waxler, C., Susman, E. J., & Dorn, L. D. (2014). Within-adolescent coupled changes in cortisol with DHEA and testosterone in response to three stressors. Psychoneuroendocrinology, 41, 33-35.

• Marceau, K., Horwitz, B. N., Narusyte, J., Ganiban, J. M., Spotts, E., Reiss, D., & Neiderhiser, J. M. (2013). Gene-environment correlation underlying the association between parental negativity and adolescent externalizing problems. Child Development, 84(6), 2031-2046.

• Marceau, K., Ram, N., Neiderhiser, J. M., Laurent, H. K., Reiss, D., Shaw, D. S., Fisher, P., Natsuaki, M. N., & Leve, L. D. (2013). Disentangling the effects of genetic, prenatal, and parenting influences on children’s HPA flexibility. Stress: The International Journal on the Biology of Stress, 16(6), 607-615.

• Neiderhiser, J. M., Marceau, K., & Reiss, D. (2013). Four factors for the initiation of substance use by young adulthood: A 10-year follow-up twin and sibling study of marital conflict, monitoring, siblings, and peers. Development and Psychopathology, 25(Special Issue 01), 133-149.

• Marceau, K., Dorn, L. D., & Susman, E. J. (2012). Stress and puberty-related hormone reactivity, negative emotionality, and parent–adolescent relationships. Psychoneuroendocrinology, 37(8), 1286-1298.

• Marceau, K., Neiderhiser, J., Lichtenstein, P., & Reiss, D. (2012). Genetic and environmental influences on the association between pubertal maturation and internalizing symptoms. Journal of Youth and Adolescence, 41(9), 1111-1126.

• Marceau, K., Ram, N., Houts, R., Grimm, K., & Susman, E. J. (2011). Individual differences in boys’ and girls’ timing and tempo of puberty: Modeling development with nonlinear growth models. Developmental Psychology, 47(5), 1389-1409.

• Zahn-Waxler, C., Shirtcliff, E. A., & Marceau, K. (2008). Disorders of childhood and adolescence: Gender and psychopathology. Annual Review of Clinical Psychology, 4(1), 275-303.

Education

• Postdoctoral Fellow, 2015-2016, Division of Behavioral Genetics, Rhode Island Hospital and Brown University Medical School

• Postdoctoral Fellow, 2013-2015, Center for Alcohol and Addiction Studies, Brown University School of Public Health

• PhD, 2013, Developmental Psychology, The Pennsylvania State University

• MS, 2011, Developmental Psychology, The Pennsylvania State University

• BA, 2006, Psychology and Philosophy, University of Wisconsin-Madison

Honors

• 2016:  APS Rising Star, Association for Psychological Science

• 2016:  Early Career Scholar, The New Biobehavioral Science of Puberty, Society for Research on Adolescence

Recent Grants

• 2018-2023: R01 DA045108, Co-Investigator, Neiderhiser (PI), NIDA, An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturation, Total Costs: $3,827,586

• 2018-2019: AgSEED, Principal Investigator, Purdue University, Adolescent Substance Use: Indiana Community Needs and Education through Extension, Total Costs: $50,015

• 2016-2021: K01 DA039288, Principal Investigator, NIDA, Bio-behavioral developmental origins of adolescent substance use, Total Costs: $876,112

• 2016: Social Science Research Institute Level 1, Co-Investigator, Neiderhiser (PI), Pennsylvania State University, Remote collection of hair samples for pubertal hormone assay analysis, Total Costs: $4,116

• 2012-2013: F31 DA033737, Principal Investigator, NIDA, Genetic, hormone, and family environmental influences on adolescent substance use, Total Costs: $39,706

Professional Service

Ad Hoc Reviewer

Alcohol and Alcoholism, American Journal of Human Biology, Behavior Genetics, Child Abuse and Neglect, Child Development, Developmental Psychobiology, Developmental Psychology, Drug and Alcohol Dependence, Genes, Health Psychology, Hormones and Behavior, Journal of Abnormal Psychology, Journal of Adolescence, Journal of Adolescent Health, Journal of Abnormal Child Psychology, Journal of Child Psychology and Psychiatry and Allied Disciplines, Journal of Early Adolescence, Journal of Family Psychology, Journal of Research on Adolescence, Journal of Studies on Alcohol and Drugs, Neuropsychiatry, Prevention Science, Psychological Medicine, Psychological Science, Psychoneuroendocrinology, Tobacco Induced Diseases

Conference Reviewer

• Meetings of the Society For Research on Child Development
• Meetings of the American Psychological Association Division 50 (addictions)
• Meetings of the Society for Research on Adolescence

Courses Recently Taught

HDFS 627: Multilevel Modeling