Kristine Marceau

Research Interests

Gene-environment interplay, prenatal experiences, physiological responses to stress, pubertal development, parenting and parent-child relationships, development of behavior problems and substance use

Biography

I have had a long-standing interest in understanding how biological and environmental processes work together over time in the service of identifying which types of problems children and adolescents are likely to exhibit, and which youth will develop persistent problems. My research tackles questions about the development of behavior problems and substance use across the lifespan by incorporating the integrated roles of genetics, prenatal risk, neuroendocrine development, and the family environment across childhood and adolescence. I am currently funded on a K01 career development award from the National Institute on Drug Abuse to examine biobehavioral developmental pathways and interactions among these influences for adolescent substance use. My research has a strong focus on biological underpinnings (e.g., genetics, hormones) of neurodevelopmental behavior and problems, and a strong methodological focus, including multiple models of change and developmental trajectories, and methodological considerations for repeated measures, genetic, and prenatal data.

Selected Publications

• Bidwell, L. C., Marceau, K., Brick, L., Karoly, H. C., Todorov, A. A., Palmer, R. H., Heath, A. C., & Knopik V. S. (accepted). Prenatal exposure effects on early adolescent substance use: A genetically-informed Bayesian approach. Journal of Studies on Alcohol and Drugs.

• Marceau, K., Bidwell, L. C., Karoly, H. C., Schettini Evans, A., Todorov, A. A., Palmer, R. H. C., Heath, A. C., & Knopik, V. S. (accepted) Within-family effects of smoking during pregnancy on ADHD: The importance of phenotype. Journal of Abnormal Child Psychology.

• Marceau, K., & Jackson, K. M. (in press). Deviant peers as a mediator of pubertal timing – substance use associations: Moderating role of parental knowledge. Journal of Adolescent Health. [ePub ahead of print] 

• Spirito, A., Hernandez, L., Marceau, K., Cancilliere, M. K., Graves, H. R., Rodriquez, A. M., & Knopik, V. S. (in press). A brief intervention for parents of adolescents with alcohol misuse: Effects on adolescents and their siblings. Journal of Substance Abuse Treatment. [ePub ahead of print]

• Brooker, R. J., Davey, K. M., Marceau, K., Najjar, R., Leve, L. D., Ganiban, J. M., Shaw, D. S., Reiss, D., & Neiderhiser, J. M. (2016). Genetic risk for anxiety moderates the association between child-centered parenting and early social inhibition. Developmental Origins of Health and Disease, 6, 602-615. doi: 10.1017/S204017441600043X

• Knopik, V. S., Marceau, K., Bidwell, L. C., Palmer, R., Smith, T., & Heath, A. C. (2016). Smoking during pregnancy and ADHD risk: A genetically informed, multiple-rater approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171B, 971-981. doi: 10.1002/ajmg.b.32421

• Knopik, V. S., Marceau, K., Palmer, R. H. C., Smith, T. F., & Heath, A. C. (2016). Maternal smoking during pregnancy and offspring birth weight: A genetically-informed approach incorporating multiple raters. Behavior Genetics, 46, 353-364. doi:10.1007/s10519-015-9750-6

• Marceau, K., De Araujo-Greecher, M., Miller, E. S., Massey, S. H., Mayes, L. C., Ganiban, J. M., Reiss, D., Shaw, D. S., Leve, L. D., & Neiderhiser, J. M. (2016). The Perinatal Risk Index: Early risks experienced by domestic adoptees in the United States. Plos One, 11: e150486. doi:10.1371/journal.pone.0150486

• Marceau, K., Knopik, V. S., Neiderhiser, J. M., Lichtenstein, P., Spotts, E., Ganiban, J., & Reiss, D. (2016). Adolescent age moderates genetic and environmental influences on parent-adolescent positivity and negativity: Implications for genotype-environment correlation. Development and Psychopathology, 28, 149-66. doi:10.1017/S0954579415000358

• Marceau, K., Palmer, R. H. C., Neiderhiser, J. M., Smith, T. F., McGeary, J. E., & Knopik, V. S. (2016). Passive rGE or developmental gene-environment cascade? An investigation of the role of xenobiotic genes in the association between smoking during pregnancy and child birthweight. Behavior Genetics, 46, 365-77. doi:10.1007/s10519-016-9778-2

• Marceau, K., McMaster, M. T. B., Smith, T. F., Daams, J. G., van Beijsterveldt, C. E. M., Boomsma, D. I., & Knopik, V. S. (2016). The prenatal environment in twin studies: A review on chorionicity. Behavior Genetics, 46, 286-303. doi:10.1007/s10519-016-9782-6

• Neiderhiser, J. M., Marceau, K., De Araujo-Greecher, M., Ganiban, J. M., Mayes, L. C., Shaw, D. S., Reiss, D., & Leve, L. D. (2016). Estimating the roles of genetic risk, perinatal risk, and marital hostility on early childhood adjustment: Medical records and self-reports. Behavior Genetics, 46, 334-52. doi:10.1007/s10519-016-9788-0

• Short, S. J., Stalder, T., Marceau, K., Entringer, S., Moog, N. K., Shirtcliff, E. A., Wadhwa, P. D., & Buss, C. (2016). Correspondence between hair cortisol concentrations and 30-day integrated daily salivary and weekly urinary cortisol measures. Psychoneuroendocrinology, 71, 12-18. doi:10.1016/j.psyneuen.2016.05.007

• Horwitz, B. N., Marceau, K., Ganiban, J. M., Spotts, E. L., Lichtenstein, P., Reiss, D., & Neiderhiser, J. M. (2015). Parental hostility and child somatic problems using an extended children of twins design. Journal of Family Psychology, 29, 283-289. doi:10.1037/fam0000065

• Knopik, V. S., Heath, A., Marceau, K., Palmer, R., McGeary, J. E., Todorov, A., & Schettini Evans, A. (2015). Missouri mothers and their children: A family study of the effects of genetics and the prenatal environment. Twin Research and Human Genetics, 18(5), 485-496. doi:10.1017/thg.2015.46

• Marceau, K., Abar, C. C., & Jackson, K. M. (2015). Interactions of self-reported timing and tempo of puberty and parental knowledge predict substance initiation. Journal of Youth and Adolescence, 44, 1720-1734. doi:10.1007/s10964-015-0335-8

• Marceau, K., Laurent, H. K., Neiderhiser, J. M., Reiss, D., Shaw, D. S., Fisher, P., Natsuaki, M. N., & Leve, L. D. (2015). Combined influences of genes, prenatal environment, cortisol, and parenting on the development of children’s internalizing vs. externalizing problems. Behavior Genetics, 45, 268-282. doi:10.1007/s10519-014-9689-z

• Marceau, K., Ram, N., & Susman, E. J. (2015). Development and lability in the parent-child relationship through adolescence: Associations with pubertal timing and tempo. Journal of Research on Adolescence, 25, 474-489. doi:10.1111/jora.12139

• Marceau, K., Ruttle, P. L., Shirtcliff, E. A., Hastings, P. D., Klimes-Dougan, B., & Zahn-Waxler, C. (2015). Within-person coupling of changes in cortisol, testosterone, and DHEA across the day. Developmental Psychobiology, 57(6), 654-669. doi:10.1002/dev.21173

• Marceau, K., Ruttle, P. L., Shirtcliff, E. A., Essex, M. J., & Susman, E. J. (2015). Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health. Developmental Psychobiology, 57(6), 742-768. doi:10.1002/dev.21214

• Marceau, K., Zahn-Waxler, C., Shirtcliff, E. A., Schreiber, J. E., Hastings, P. D., & Klimes-Dougan, B. (2015). Adolescents’, mothers’, and fathers’ gendered coping strategies during conflict: Youth and parent influences on conflict resolution and psychopathology. Development & Psychopathology, 27, 1025-1044. doi:10.1017/S0954579415000668

• Nederhof, E., Marceau, K., Shirtcliff, E. A., Hastings, P. D., & Oldehinkel, A. J. (2015). Autonomic and adrenocortical interactions predict mental health in late adolescence: The TRAILS study. Journal of Abnormal Child Psychology, 43, 847-861. doi:10.1007/s10802-014-9958-6

• Shirtcliff, E. A., Dismukes, A. R., Marceau, K., Ruttle, P. L., Simmons, J., & Han, G. (2015). A dual-axis approach to understanding neuroendocrine development. Developmental Psychobiology, 57(6), 643-653. doi:10.1002/dev.21337

• Marceau, K., Narusyte, J., Ganiban, J., Spotts, E., Lichtenstein, P., Reiss, D., & Neiderhiser, J. M. (2014). Parental knowledge is an environmental influence on adolescent externalizing. Journal of Child Psychology and Psychiatry, 56, 130-137. doi:10.1111/jcpp.12288

• Marceau, K., Shirtcliff, E. A., Hastings, P. D., Klimes-Dougan, B., Zahn-Waxler, C., Susman, E. J., & Dorn, L. D. (2014). Within-adolescent coupled changes in cortisol with DHEA and testosterone in response to three stressors. Psychoneuroendocrinology, 41, 33-35. doi:10.1016/j.psyneuen.2013.12.002

• Laurent, H. K., Leve, L. D., Neiderhiser, J. M., Natsuaki, M. N., Shaw, D. S., Fisher, P. A., Marceau, K., Harold, G., & Reiss, D. (2013). Effects of parental depressive symptoms on child adjustment moderated by hypothalamic pituitary adrenal activity: Within- and between-family risk. Child Development, 84(2), 528-542. doi:10.1111/j.1467-8624.2012.01859.x

• Marceau, K., Hajal, N., Leve, L. D., Reiss, D., Shaw, D. S., Ganiban, J. M., Mayes, L. C., & Neiderhiser, J. M. (2013). Measurement and associations of pregnancy risk factors with genetic influences, postnatal environmental influences, and toddler behavior. International Journal of Behavioral Development, 37(4), 366-375. doi:10.1177/0165025413489378

• Marceau, K., Horwitz, B. N., Narusyte, J., Ganiban, J. M., Spotts, E., Reiss, D., & Neiderhiser, J. M. (2013). Gene-environment correlation underlying the association between parental negativity and adolescent externalizing problems. Child Development, 84(6), 2031-2046. doi:10.1111/cdev.12094

• Marceau, K., Ram, N., Neiderhiser, J. M., Laurent, H. K., Reiss, D., Shaw, D. S., Fisher, P., Natsuaki, M. N., & Leve, L. D. (2013). Disentangling the effects of genetic, prenatal, and parenting influences on children’s HPA flexibility. Stress: The International Journal on the Biology of Stress, 16(6), 607-615. doi:10.3109/10253890.2013.825766

• Neiderhiser, J. M., Marceau, K., & Reiss, D. (2013). Four factors for the initiation of substance use by young adulthood: A 10-year follow-up twin and sibling study of marital conflict, monitoring, siblings, and peers. Development and Psychopathology, 25(Special Issue 01), 133-149. doi:10.1017/S0954579412000958

• Marceau, K., Dorn, L. D., & Susman, E. J. (2012). Stress and puberty-related hormone reactivity, negative emotionality, and parent–adolescent relationships. Psychoneuroendocrinology, 37(8), 1286-1298. doi:http://dx.doi.org/10.1016/j.psyneuen.2012.01.001

• Marceau, K., Humbad, M. N., Burt, S. A., Klump, K. L., Leve, L. D., & Neiderhiser, J. M., (2012). Genetic and environmental influences on observed externalizing behavior in middle childhood and early adolescence. Behavior Genetics, 42(1), 30-39. doi:10.1007/s10519-011-9481-2

• Marceau, K., Neiderhiser, J., Lichtenstein, P., & Reiss, D. (2012). Genetic and environmental influences on the association between pubertal maturation and internalizing symptoms. Journal of Youth and Adolescence, 41(9), 1111-1126. doi:10.1007/s10964-012-9762-y

• Marceau, K., Ram, N., Houts, R., Grimm, K., & Susman, E. J. (2011). Individual differences in boys' and girls' timing and tempo of puberty: Modeling development with nonlinear growth models. Developmental Psychology, 47(5), 1389-1409. doi:10.1037/a0023838

• Zahn-Waxler, C., Shirtcliff, E. A., & Marceau, K. (2008). Disorders of childhood and adolescence: Gender and psychopathology. Annual Review of Clinical Psychology, 4(1), 275-303. doi:10.1146/annurev.clinpsy.3.022806.091358

Invited Chapters

• Marceau, K., & Neiderhiser, J. M. (2013). Influences of gene environment interaction and correlation on disruptive behavior in the family context. In P. Tolan, & B. Leventhal (Eds.), Advances in clinical child and adolescent psychopathology, Volume I: Disruptive behavior. Springer.

• Horwitz, B., Marceau, K., & Neiderhiser, J. M. (2011). Family relationship influences on development: What can we learn from genetic research? In K. Kendler, S. Jaffee, & D. Romer, (Eds.), The dynamic genome and mental health: The role of genes and environments in youth development. Oxford: Oxford University Press.

Education

• Postdoctoral Fellow, 2015-2016, Division of Behavioral Genetics, Rhode Island Hospital and Brown University Medical School

• Postdoctoral Fellow, 2013-2015, Center for Alcohol and Addiction Studies, Brown University School of Public Health

• PhD, 2013, Developmental Psychology, The Pennsylvania State University

• MS, 2011, Developmental Psychology, The Pennsylvania State University

• BA, 2006, Psychology and Philosophy, University of Wisconsin-Madison

Honors

• 2016:  APS Rising Star, Association for Psychological Science

• 2016:  Early Career Scholar, The New Biobehavioral Science of Puberty, Society for Research on Adolescence

Recent External Grants

• 2016-2021: K01 DA039288, Principal Investigator, NIDA, Bio-behavioral developmental origins of adolescent substance use, Total Costs: $876,112

• 2016: Social Science Research Institute Level 1, Co-Investigator, Neiderhiser (PI), Pennsylvania State University, Remote collection of hair samples for pubertal hormone assay analysis, Total Costs: $4,116

• 2012-2013: F31 DA033737, Principal Investigator, NIDA, Genetic, hormone, and family environmental influences on adolescent substance use, Total Costs: $39,706

• 2010: Social Science Research Institute Level 1, Co-Investigator, Ram (PI), Pennsylvania State University, Methodological innovations in modeling timing and tempo of puberty: A multiple cohort 50-year approach, Total Costs: $4,864
  
  

Professional Service

Ad Hoc Reviewer for:

Alcohol and Alcoholism, American Journal of Human Biology, Behavior Genetics, Child Abuse and Neglect, Child Development, Developmental Psychobiology, Developmental Psychology, Drug and Alcohol Dependence, Genes, Health Psychology, Hormones and Behavior, Journal of Abnormal Psychology, Journal of Adolescence, Journal of Adolescent Health, Journal of Abnormal Child Psychology, Journal of Child Psychology and Psychiatry and Allied Disciplines, Journal of Early Adolescence, Journal of Family Psychology, Journal of Research on Adolescence, Journal of Studies on Alcohol and Drugs, Neuropsychiatry, Prevention Science, Psychological Medicine, Psychological Science, Psychoneuroendocrinology, Tobacco Induced Diseases

Conference Reviewer for:

• 2017 Meeting of the Society for Research on Child Development Biennial Meeting, “Panel #2: Biology and Neuroscience” chaired by Drs. Jennifer H. Pfeifer and Elizabeth A. Shirtcliff

• 2016 Meeting of the American Psychological Association Division 50 (addictions) co-chaired by Drs. Lara Ray and Christian Hendershot.

• 2015 Meeting of the American Psychological Association Division 50 (addictions) co-chaired by Drs. Suzette Glasner-Edwards and Kristina Jackson.

• 2015 Meeting of the Society for Research on Child Development Biennial Meeting, “Panel #12: Parenting & Parent-Child Relationships” chaired by Drs. Jean M. Ispa and Mary Dozier.

• 2012 Meetings of the Society for Research on Child Development Developmental Methodology Themed Meeting, “Intraindividual Longitudinal Analysis” chaired by Dr. Nilam Ram.

• 2012 Meetings of the Society for Research on Adolescence Review Panel, “Biological Processes and Evolutionary Perspectives” chaired by Dr. Carolyn Tucker-Halpern. Mentee reviewer.