Kristine Marceau

Research Interests

Gene-environment interplay, prenatal experiences, physiological responses to stress, pubertal development, parenting and parent-child relationships, development of behavior problems and substance use

Biography

I have had a long-standing interest in understanding how biological and environmental processes work together over time in the service of identifying which types of problems children and adolescents are likely to exhibit, and which youth will develop persistent problems. My research tackles questions about the development of behavior problems and substance use across the lifespan by incorporating the integrated roles of genetics, prenatal risk, neuroendocrine development, and the family environment across childhood and adolescence. My research has a strong focus on biological underpinnings (e.g., genetics, hormones) of neurodevelopmental behavior and problems, and a strong methodological focus, including multiple models of change and developmental trajectories, and methodological considerations for repeated measures, genetic, and prenatal data.

Follow this link to a description of current projects.

In the News

Selected Publications 

(full list of publications)  **Undergraduate, *Graduate Student/Mentee

• Marceau, K., Wang*, W., Robertson*, O.C., & Shirtcliff, E.A. (in press). A systematic review of hair cortisol during pregnancy: Reference ranges and methodological considerations. Psychoneuroendocrinology.

• Marceau, K. & Neiderhiser, J.M. (in press). Generalist genes and specialist environments for adolescent internalizing and externalizing problems: A test of severity and directionality. Development and Psychopathology.

• Ruiz, Y., MacDermid Wadsworth, S., Abbott, A.R., Elias, C.M., Marceau, K., Purcell, M., Redick, T.S., Richards, E.A., Schlesinger-Devlin, E. (2020) Ultra-rapid Development and Deployment of a Family Resilience Program During the COVID-19 Pandemic; Lessons Learned from Families Tackling Tough Times Together. Journal of Military, Veteran, and Family Health.

• Mishra*, A.A., & Marceau, K. (2020). Childhood Maltreatment Exposure and Depressive Symptoms in Adulthood: Differential Effects of Stress Dysregulation and Perceived Stress. Aging and Mental Health, 24, 1837-1846.

• Marceau, K., Brick, L., Knopik, V.S., & Reijneveld, S.A. (2020). Developmental pathways from genetic, prenatal, parenting and emotional/behavioral risk to cortisol reactivity and adolescent substance use: A TRAILS study. Journal of Youth and Adolescence, 49, 17-31.

• Mishra* A.A., Friedman, E.M., Mihalec-Adkins*, B.P., Evich*, C.D., Christ, S.L., & Marceau, K. (2020). Profiles of childhood maltreatment and physical functional limitations in late adulthood: Does subjective sleep problems in midlife mediate these associations? Psychology and Health, 35, 573-592.

• Horvath*, G., Knopik, V.S. & Marceau, K., (2020). Polygenic Influences on Pubertal Timing & Tempo and Depressive Symptoms in Boys and Girls. Journal of Research on Adolescence, 21, 568-579.

• Abel* E., Schwichtenberg, A.J., Mannin*, R., & Marceau, K. (2020). Brief Report: A gene enrichment approach applied to sleep and autism. Journal of Autism and Developmental Disorders, 50, 1834-1840.

• Marceau, K., Nair* N., Rogers, M.L., & Jackson, K.M. (2020). Lability in parent- and child-based sources of parental monitoring is differentially associated with adolescent substance use. Prevention Science, 21, 568-579.

• Rector, J.L., Marceau, K., & Friedman, E. (2020). Moderation of the association between chronic medical conditions and functional limitations over time by physical activity: Effects of age. Journals of Gerontology, Series A, 75, 168-174.

• Marceau, K., Kirisci, L., & Tarter, R.E. (2019). Correspondence of pubertal neuroendocrine and Tanner Stage changes in boys and associations with substance use. Child Development, 90, e763-e782.

• Marceau, K., Rolan*, E., Leve, L.D., Ganiban, J.M., Reiss, D., Shaw, D.S., Natsuaki, M.N., & Neiderhiser, J.M. (2019). Parenting and prenatal risk as moderators of genetic influences on conduct problems during middle childhood. Developmental Psychology, 55, 1164-1181.

• Knopik, V.S., Marceau, K., Bidwell, C.L., & Rolan*, E. (2019). Prenatal substance exposure and offspring development: Does DNA methylation play a role? Neurotoxicology and Teratology, 75, 50-63.

• Marceau, K., Abel*, E., Duncan, R.J., Moore, P.J., Leve, L.D., Reiss, D., Shaw, D.S., Natsuaki, M., Neiderhiser, J.M., & Ganiban, J.M. (2019). Longitudinal associations of sleep duration, morning and evening cortisol, and BMI during childhood. Obesity, 27, 645-652.

• Marceau, K., Hottle, S.**, & Yatcilla, J.K. (2019). Puberty in the last 25 years: A retrospective bibliometric analysis. Journal of Research on Adolescence, 29, 96-114.

• Marceau, K., & Abel*, E. (2018). Mechanisms of cortisol – substance use associations across the substance use progression: A theoretical synthesis and hypothesis generation through gene enrichment. Neuroscience and Biobehavioral Reviews, 92, 128-139.

• Rolan* E., & Marceau, K. (2018). Individual and sibling characteristics: Parental differential treatment and adolescent externalizing behaviors. Journal of Youth and Adolescence, 47, 2565-2553.

• Marceau, K., Bidwell, L. C., Karoly, H. C., Schettini Evans, A., Todorov, A. A., Palmer, R. H. C., Heath, A. C., & Knopik, V. S. (2018) Within-family effects of smoking during pregnancy on ADHD: The importance of phenotype. Journal of Abnormal Child Psychology, 46, 685-699.

• Marceau, K., & Jackson, K. M. (2017). Deviant peers as a mediator of pubertal timing – substance use associations: Moderating role of parental knowledge. Journal of Adolescent Health, 61, 53-20.

• Knopik, V. S., Marceau, K., Palmer, R. H. C., Smith, T. F., & Heath, A. C. (2016). Maternal smoking during pregnancy and offspring birth weight: A genetically-informed approach incorporating multiple raters. Behavior Genetics, 46, 353-364.

• Marceau, K., De Araujo-Greecher, M., Miller, E. S., Massey, S. H., Mayes, L. C., Ganiban, J. M., Reiss, D., Shaw, D. S., Leve, L. D., & Neiderhiser, J. M. (2016). The Perinatal Risk Index: Early risks experienced by domestic adoptees in the United States. Plos One, 11: e150486.

• Marceau, K., Palmer, R. H. C., Neiderhiser, J. M., Smith, T. F., McGeary, J. E., & Knopik, V. S. (2016). Passive rGE or developmental gene-environment cascade? An investigation of the role of xenobiotic genes in the association between smoking during pregnancy and child birthweight. Behavior Genetics, 46, 365-77.

• Short, S. J., Stalder, T., Marceau, K., Entringer, S., Moog, N. K., Shirtcliff, E. A., Wadhwa, P. D., & Buss, C. (2016). Correspondence between hair cortisol concentrations and 30-day integrated daily salivary and weekly urinary cortisol measures. Psychoneuroendocrinology, 71, 12-18.

• Marceau, K., Laurent, H. K., Neiderhiser, J. M., Reiss, D., Shaw, D. S., Fisher, P., Natsuaki, M. N., & Leve, L. D. (2015). Combined influences of genes, prenatal environment, cortisol, and parenting on the development of children’s internalizing vs. externalizing problems. Behavior Genetics, 45, 268-282.

• Marceau, K., Ram, N., & Susman, E. J. (2015). Development and lability in the parent-child relationship through adolescence: Associations with pubertal timing and tempo. Journal of Research on Adolescence, 25, 474-489.

• Marceau, K., Ruttle, P. L., Shirtcliff, E. A., Hastings, P. D., Klimes-Dougan, B., & Zahn-Waxler, C. (2015). Within-person coupling of changes in cortisol, testosterone, and DHEA across the day. Developmental Psychobiology, 57(6), 654-669. doi:10.1002/dev.21173

• Marceau, K., Ruttle, P. L., Shirtcliff, E. A., Essex, M. J., & Susman, E. J. (2015). Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health. Developmental Psychobiology, 57(6), 742-768.

• Marceau, K., Zahn-Waxler, C., Shirtcliff, E. A., Schreiber, J. E., Hastings, P. D., & Klimes- Marceau, K., Narusyte, J., Ganiban, J., Spotts, E., Lichtenstein, P., Reiss, D., & Neiderhiser, J. M. (2014). Parental knowledge is an environmental influence on adolescent externalizing. Journal of Child Psychology and Psychiatry, 56, 130-137.

• Marceau, K., Shirtcliff, E. A., Hastings, P. D., Klimes-Dougan, B., Zahn-Waxler, C., Susman, E. J., & Dorn, L. D. (2014). Within-adolescent coupled changes in cortisol with DHEA and testosterone in response to three stressors. Psychoneuroendocrinology, 41, 33-35.

• Marceau, K., Horwitz, B. N., Narusyte, J., Ganiban, J. M., Spotts, E., Reiss, D., & Neiderhiser, J. M. (2013). Gene-environment correlation underlying the association between parental negativity and adolescent externalizing problems. Child Development, 84(6), 2031-2046.

• Marceau, K., Ram, N., Neiderhiser, J. M., Laurent, H. K., Reiss, D., Shaw, D. S., Fisher, P., Natsuaki, M. N., & Leve, L. D. (2013). Disentangling the effects of genetic, prenatal, and parenting influences on children’s HPA flexibility. Stress: The International Journal on the Biology of Stress, 16(6), 607-615.

• Marceau, K., Ram, N., Houts, R., Grimm, K., & Susman, E. J. (2011). Individual differences in boys’ and girls’ timing and tempo of puberty: Modeling development with nonlinear growth models. Developmental Psychology, 47(5), 1389-1409.

• Zahn-Waxler, C., Shirtcliff, E. A., & Marceau, K. (2008). Disorders of childhood and adolescence: Gender and psychopathology. Annual Review of Clinical Psychology, 4(1), 275-303.

Education

• Postdoctoral Fellow, 2015-2016, Division of Behavioral Genetics, Rhode Island Hospital and Brown University Medical School

• Postdoctoral Fellow, 2013-2015, Center for Alcohol and Addiction Studies, Brown University School of Public Health

• PhD, 2013, Developmental Psychology, The Pennsylvania State University

• MS, 2011, Developmental Psychology, The Pennsylvania State University

• BA, 2006, Psychology and Philosophy, University of Wisconsin-Madison

External Grants

• 2018-2023: R01 DA045108, Co-Investigator, Neiderhiser (PI), NIDA, An Adoption Study of the Development of Early Substance Use: The Joint Roles of Genetic Influences, Prenatal Risk, Rearing Environment, and Pubertal Maturation. Total Costs: $3,827,586

• 2016-2021: K01 DA039288, Principal Investigator, NIDA, Bio-behavioral Developmental Origins of Adolescent Substance Use. Total Costs: $876,112

• 2012-2013: F31 DA033737, Principal Investigator, NIDA, Genetic, hormone, and family environmental influences on adolescent substance use. Total Costs: $39,706

Mentored External Grants

• 2021-2023: F31 AG072824, Co-Sponsor, Teas, PI, NIA. A Life Course Perspective on Social Connectedness and Adult Health

• 2021-2023: F31 DC019281, Co-Sponsor, Kiefer, PI, NIDCD. Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS

• 2019-2020: R36 DA047563, Primary Mentor, Mishra (PI), NIDA, The Role of Substance Use Trajectory on the Association Between Childhood Maltreatment and Intimate Partner Violence: A Gene-environment Study. Total Costs: $60,194

Statistical Consultant

• 2018-2019: R34 DA043293, Consultant, Slowey (PI), NIDA, Real-time Salivary Testosterone and Extension to Mobile Application and Multiple Biomarker Quantification Capability.

• 2018: R01 AG041759, Consultant, Friedman (PI), NIA, Living Well with Later Life Multimorbidity: A Biopsychosocial Approach.

• 2018-2021: UH3 OD023389, Consultant, Leve (PI), Office of the Director-NIH, The Early Growth and Development Study Pediatric Cohort.

• 2016-2018: UG3 OD023389, Consultant, Leve (PI), Office of the Director-NIH, The Early Growth and Development Study Pediatric Cohort.

Other Appointments

• Information Officer, Executive Committee, Behavior Genetics Association 10/2018 – 06/2021

• Courtesy appointment: Department of Psychological Sciences, Clinical area, Purdue University 2017-present
  

Professional Service

Ad Hoc Grant Reviewer

• NIH CSR study section: Addiction Risks and Mechanisms study section

• Environmental influences on Child Health Outcomes (ECHO) Opportunities and Infrastructure Fund (OIF) (NIH)

• National Science Foundation (USA)

• Insight Grants, Social Sciences and Humanities Research Council of Canada

• Swiss National Science Foundation

Journal Reviewer

Statistical Consulting Editor:

Child Development

Ad Hoc:

Addiction, Addictive Behaviors, Alcohol and Alcoholism, Alcoholism: Clinical and Experimental Research, American Journal of Human Biology, Behavior Genetics, Biological Psychology, BMC-Genetics, BMC-Pediatrics, Clinical Endocrinology, Clinical Psychological Science, Clinical Psychology Review, Child Abuse and Neglect, Child Development, Comprehensive Psychoneuroendocrinology, Development and Psychopathology, Developmental Psychobiology, Developmental Psychology, Drug and Alcohol Dependence, Emotion, Genes, Genes Brain and Behavior, Health Psychology, Hormones and Behavior, JAMA-Psychiatry, Journal of Abnormal Psychology, Journal of Adolescence, Journal of Adolescent Health, Journal of Abnormal Child Psychology, Journal of Child Psychology and Psychiatry and Allied Disciplines, Journal of Early Adolescence, Journal of Family Psychology, Journal of Research on Adolescence, Journal of Studies on Alcohol and Drugs, Journal of Youth and Adolescence, Neuropsychiatry, Pediatrics, Population Research and Policy Review, Prevention Science, Proceedings of the National Academy of Sciences, Psychological Medicine, Psychological Science, Psychoneuroendocrinology, Tobacco Induced Diseases

Societies: Conference/Award Reviewer

• Behavior Genetics Association Thompson and Rowe student presentation Awards

• Meeting of the Society for Research on Child Development Biennial Meeting

• Meeting of the American Psychological Association Division 50 (addictions)

• Meetings of the Society for Research on Adolescence

Courses Recently Taught

• HDFS 627: Multilevel Modeling (Spring, 2018, 2019, Fall 2021)

• HDFS 313: Adolescent Development (Fall, 2019)