Completed Grants

Bio-behavioral developmental origins of adolescent substance use

K01 DA039288 (PI: Marceau)                                                                                                03/01/16-02/28/21

NIDA

The goals of this K01 are to improve our understanding of how multiple biological (genetic, hormone) and environmental (prenatal exposures and parenting) influences work together for the development of adolescent substance use and to prepare the Candidate for an independent career as an interdisciplinary, developmental scientist. The work conducted here will lead to better targets for prevention efforts by helping to identify the strongest predictors given multiple other influences and constructing more specific profiles of risk for determining which individuals are likely to initiate early.

Supported: Dr. Marceau, various students

The role of substance use trajectory on the association between childhood maltreatment and intimate partner violence: a gene-environment study

R36 DA047563 (PI: Mishra, Mentor: Marceau)                                                                                                07/01/19-08/31/20

NIDA

This study will evaluate the role of developmental trajectories of substance use for the association between childhood maltreatment exposures and inter-personal violence in adulthood, and whether genetic risk for substance use strengthens this developmental pathway. Understanding the roles of substance use and associated biological underpinnings for the maltreatment-violence cycle will provide critical avenues for the prevention of these associations in future generations.

Supported: Aura Mishra

Adolescent substance use: Indiana community needs and education through extension

Purpose: The primary goal of this study is to facilitate informed decision-making to improve the well-being of Indiana youth and their families. The project involves 1) information gathering, 2) an outreach component: education through Extension, and 3) qualitative community-based participatory research aimed at understanding the prevalence of adolescence substance use and needs of Indiana residents surrounding adolescent substance use prevention and resources.

Sample: 1) 200 parents of adolescents in Indiana and 87 Indiana Extension Educators; 2) ~20 Extension Educators; 3) participants of Extension Programming in participating counties.

Funding: Purdue’s AgSEED program (PI: Marceau)

Real-time Salivary Testosterone and extension to mobile Application and Multiple Biomarker Quantification Capability

Purpose: This Small Business Innovation Research Award (SBIR) will develop a new device to assay salivary testosterone in real-time. This device will be more cost effective and faster than current assay techniques, with both research and point-of-care applications. My role is as statistical consultant in order to confirm the validity of testosterone levels recovered by the new device in comparison to current gold-standard salivary testosterone assays.

Funding: National Institute on Drug Abuse: R34 DA043293 (PI: Slowey) 07/15/18-07/14/19. Dr. Marceau was a consultant on this grant.

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