Active Grants

Bio-behavioral developmental origins of adolescent substance use

K01 DA039288 (PI: Marceau)                                                                                                03/01/16-02/28/21

NIDA

The goals of this K01 are to improve our understanding of how multiple biological (genetic, hormone) and environmental (prenatal exposures and parenting) influences work together for the development of adolescent substance use and to prepare the Candidate for an independent career as an interdisciplinary, developmental scientist. The work conducted here will lead to better targets for prevention efforts by helping to identify the strongest predictors given multiple other influences and constructing more specific profiles of risk for determining which individuals are likely to initiate early.

Supports: Dr. Marceau, Gregor Horvath

An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturation.

R01 DA045108 (PI: Neiderhiser)                                                                                         04/01/18-02/28/23

NIDA

The proposed research will clarify how heritable risks and prenatal and postnatal environments work together with hormonal changes to influence the development of risk for early substance use (SU) and related problems in adolescence. My role is to lead the data core, overseeing data management, preparation, and analyses, as well as to assist in retention and recruitment of hard-to-reach families, and research dissemination.

Supports: Olivia Robertson

The Early Growth and Development Study Pediatric Cohort

UH3 OD023389 (PI: Leve)                                                                                                          09/01/18-08/31/21

Office of the Director, NIH

This Pediatric Cohort of the Environmental Influences on Child Health Outcomes (ECHO) initiative leverages and builds upon a unique existing “dual-family” adoption design to isolate early environmental exposures from heritable influences on familial clustering of health problems to contribute to ECHO’s overall goal of investigating the role of early life exposures and underlying biological mechanisms in childhood health and disease.

Dr. Marceau is a consultant on this grant.

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