Active Grants

The role of substance use trajectory on the association between childhood maltreatment and intimate partner violence: a gene-environment study

R36 DA047563 (PI: Mishra, Mentor: Marceau)                                                                                                07/01/19-08/31/20


This study will evaluate the role of developmental trajectories of substance use for the association between childhood maltreatment exposures and inter-personal violence in adulthood, and whether genetic risk for substance use strengthens this developmental pathway. Understanding the roles of substance use and associated biological underpinnings for the maltreatment-violence cycle will provide critical avenues for the prevention of these associations in future generations.

Supports: Aura Mishra

Bio-behavioral developmental origins of adolescent substance use

K01 DA039288 (PI: Marceau)                                                                                                03/01/16-02/28/21


The goals of this K01 are to improve our understanding of how multiple biological (genetic, hormone) and environmental (prenatal exposures and parenting) influences work together for the development of adolescent substance use and to prepare the Candidate for an independent career as an interdisciplinary, developmental scientist. The work conducted here will lead to better targets for prevention efforts by helping to identify the strongest predictors given multiple other influences and constructing more specific profiles of risk for determining which individuals are likely to initiate early.

Supports: Dr. Marceau, Gregor Horvath

An adoption study of the development of early substance use: the joint roles of genetic influences, prenatal risk, rearing environment, and pubertal maturation.

R01 DA045108 (PI: Neiderhiser)                                                                                         04/01/18-02/28/23


The proposed research will clarify how heritable risks and prenatal and postnatal environments work together with hormonal changes to influence the development of risk for early substance use (SU) and related problems in adolescence. My role is to lead the data core, overseeing data management, preparation, and analyses, as well as to assist in retention and recruitment of hard-to-reach families, and research dissemination.

Supports: Olivia Robertson

Adolescent Substance Use: Indiana Community Needs and Education through Extension

AgSEED (PI: Marceau)                                                                                                    03/01/2018-02/28/2019

Purdue University

The goals of this AgSEED grant are 1) information gathering, 2) an outreach component: education through Extension, and 3) qualitative community-based participatory research aimed at understanding the prevalence of adolescence substance use and needs of Indiana residents surrounding adolescent substance use prevention and resources. This research will facilitate informed decision-making to improve the well-being of Indiana youth and their families.

Supports: Nayantara Nair

The Early Growth and Development Study Pediatric Cohort

UH3 OD023389 (PI: Leve)                                                                                                          09/01/18-08/31/21

Office of the Director, NIH

This Pediatric Cohort of the Environmental Influences on Child Health Outcomes (ECHO) initiative leverages and builds upon a unique existing “dual-family” adoption design to isolate early environmental exposures from heritable influences on familial clustering of health problems to contribute to ECHO’s overall goal of investigating the role of early life exposures and underlying biological mechanisms in childhood health and disease.

Dr. Marceau is a consultant on this grant.

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