Vinny Menon

Vinny Menon Profile Picture

Identification of the Targets of Cationic Amphiphilic Polyproline Helices (CAPHs) in Intracellular Gram-Negative Bacteria

Contact Info:

menon34@purdue.edu

Training Group(s):
Chemical Biology

Current Research Interests:

Our group created a novel class of peptide-based antibiotics called Cationic Amphiphilic Polyproline Helices (CAPHs) that showed remarkable cell penetrating and  antibacterial capabilities against intracellular pathogens like Staphylococcus aureus and Escherichia coli. These CAPHs have since been conjugated to known antibiotics, such as kanamycin, via a cleavable tether in order to imbue these therapeutics with a dual mode of action against bacteria. Using techniques such as MALDI-TOF, LC/MS, cell culture, organic/peptide synthesis and enzyme kinetics assays we are seeking to determine the intracellular target(s) of these conjugate antibiotics and better understand their interaction.

  • Student Profile

Ernest C. Young Hall, Room 170 | 155  S. Grant Street, West Lafayette, IN 47907-2114 | 765-494-2600

© 2017 Purdue University | An equal access/equal opportunity university | Copyright Complaints | Maintained by The Purdue University Graduate School

If you have trouble accessing this page because of a disability, please contact The Purdue University Graduate School.