Jozlyn Clasman

Jozlyn Clasman Profile Picture

Mechanisms of Viral Proteases in Coronavirus Replication and Pathogenesis

Contact Info:

Training Group(s):
Biomolecular Structure and Biophysics

Current Research Interests:

Our lab studies coronaviruses (CoVs), a group of RNA viruses that cause mild infection to severe disease in both animal and human populations. We focus on the structure and function of virus-encoded papain-like proteases (PLPs). These enzymes facilitate both RNA replication and virus evasion of the host-innate immune system. Using biophysical, biochemical, and kinetic techniques, we compare the action of different PLPs from human (i.e. SARS-CoV, MERS-CoV) and animal CoVs (i.e. FIPV, MHV, PEDV) towards critical host signaling molecules, such as ubiquitin and interferon stimulating gene 15, which would otherwise function in viral clearance. The goal of our research is to specifically engineer PLPs in the viral genome to no longer counteract the immune system. Ultimately, our research will provide insight into the development of vaccines to effectively treat coronavirus infection.


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