Richard M. van Rijn

Richard M. van Rijn Profile Picture

Associate Professor of Medicinal Chemistry and Molecular Pharmacology
Ph.D., Vrije Universiteit Amsterdam

Contact Info:
RHPH 506C 

Training Group(s):
Membrane Biology
Integrative Neuroscience

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

We carry out preclinical drug discovery, including hit identification, lead optimization, assay development, behavioral efficacy and toxicity studies as well as pharmacological studies into the mechanism of action of therapeutic and adverse drug effects. We collaborate with multiple labs both at Purdue and at UIC and Washington University to identify both synthetic, semi-synthetic and natural product-derived opioids.

Selected Publications:

Ko MJ, Chiang T, Mukadam AM, Mulia, GE, Gutridge AM, Chester JA, Van Rijn RM, β-arrestin-dependent ERK signaling positively correlates with reduced anxiety-like and conditioned fear-related behavior in mice, Science Signaling, 2021 accepted,

Creed SM1, Gutridge AM1, Argade MD, Hennessy MR, Brent Friesen JJB, Pauli GF, van Rijn RM#, Riley AP#, Isolation and Pharmacological Characterization of six Opioidergic Picralima nitida Alkaloids, J Natural products, 2021, 84(1):71-80, PMID: 33326237, PMC7932029, doi: 10.1021/acs.jnatprod.0c01036

1Gutridge AM, 1Robins MT, 1Cassell RJ, 1Uprety R, Mores KL, Ko MJ, Pasternak G, Majumdar S, Van Rijn RM, G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder. Br J Pharmacol, 2020, 177(7): 1497-1513, PMID: 31705528, PMC7060366 DOI:10.1111/bph.14913. Editor’s Choice

1Cassell RJ, 1Mores KL, Zerfas BL, AHA Abdallah, Lill MA, Trader DJ, Van Rijn RM, Rubsicolins are naturally occurring G-protein-biased delta opioid receptor peptide, Eur Neuropsychopharmacol, 2019, 29(3):450-456, PMID:30591345, PMC6421079, doi: 10.1016/j.euroneuro.2018.12.013.

Robins MT, Chiang T, Mores, KL, Alongkronrusmee D, Van Rijn RM, Critical role for Gi-protein activity in the dorsal striatum in the reduction of voluntary alcohol intake in C57Bl/6 mice, 2018, Front. Psychiatry (Special topics in opioid research), 9 (112): 1-14, PMID:29686629, PMC5900748, DOI:10.3389/fpsyt.2018.00112

Alongkronrusmee D, Chiang T, Van Rijn RM, Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57BL/6 mice. Drug Alcohol Depend, 2016, 167:190-198 PMID: 27567436, PMC5325684, DOI:10.1016/j.drugalcdep.2016.08.017

Chiang T, Sansuk K, Van Rijn RM, β-arrestin 2 dependence of delta opioid receptor agonists is correlated with alcohol intake., Br. J Pharmacol, 2016, 173, 332-343, PMID:26507558, PMC4940619, doi: 10.1111/bph.13374

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