Interdisciplinary Life Science - PULSe Great research is a matter of choice

Silvia Stan

Silvia Stan Profile Picture

Assistant Professor of Nutrition Science
PhD, Oregon State University, 2004

Contact Info:
(765) 496-3847

Training Group(s):
Molecular Signaling and Cancer Biology

Current Research Interests:

Research in Dr. Stan's laboratory focuses on cancer prevention with diet-derived bioactive compounds. Our goal is to determine the cancer preventive activity of promising diet-derived bioactive compounds and to understand their mechanisms of action by identifying key molecular targets. Current research focuses primarily on pancreatic and breast cancer chemoprevention.  

Selected Publications:

  • Kiesel V.A., Stan S.D.* Diallyl      trisulfide, a chemopreventive agent from Allium vegetables, inhibits      alpha-secretases in breast cancer cells. Biochemical and Biophysical Research Communications 2017      484(4): 833-838. (*, PI and corresponding author)
  • Stan S.D.*, Singh S.V., Whitcomb      D.C., and Brand R.E. Phenethyl isothiocyanate inhibits proliferation and      induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2      xenograft animal model. Nutrition      and Cancer, 2014 66(4): 747-755.
  • Stan, S.D.*, Singh, S.V., and      Brand, R.E. Chemoprevention strategies for pancreatic cancer. Nature Reviews Gastroenterology and      Hepatology, 2010 7(6): 347-356.
  • Stan, S.D. and Singh, S.V.      Transcriptional repression and inhibition of nuclear translocation of      androgen receptor by diallyl trisulfide in human prostate cancer cells. Clinical Cancer Research, 2009      15(15):4895-4903.
  • Singh, S.V., Warin, R., Xiao,      D., Powolny, A.A., Stan, S.D., Arlotti, J.A., Zeng, Y., Hahm, E.R.,      Marynowski, S.W., Bommareddy, A., Desai, D., Amin, S., Parise, R.A.,      Beumer, J.H., and Chambers, W.H. Sulforaphane inhibits prostate      carcinogenesis and pulmonary metastasis in TRAMP mice in association with      increased cytotoxicity of natural killer cells. Cancer Research, 2009 69(5): 2117-2125.
  • Stan, S.D., Zeng, Y., and      Singh, S.V. Ayurvedic medicine constituent withaferin A causes G2 and M      phase cell cycle arrest in human breast cancer cells. Nutrition and Cancer, 2008 60: 51-606.
  • Stan, S.D., Hahm, E.R., Warin,      R., and Singh, S.V. Withaferin A causes FOXO3a- and Bim- dependent      apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Research, 2008 68(18): 7661-7669.
  • Singh, S.V., Powolny, A.A.,      Stan, S.D., Xiao, D., Arlotti, J.A., Warin, R., Hahm, E.R., Marynowski,      S.W., Bommareddy, Potter, D.M., and Dhir, R. Garlic constituent diallyl      trisulfide prevents development of poorly-differentiated prostate cancer      and pulmonary metastasis multiplicity in TRAMP mice. Cancer Research, 2008 68(22): 9503-9511.
  • Stan, S.D., Kar, S., Stoner,      G.D., and Singh, S.V. Bioactive food components and cancer risk reduction.      Journal of Cellular Biochemistry,      2008 104(1): 339-356.
  • Herman-Antosiewicz, A., Stan,      S.D., Hahm, E.R., Xiao, D., and Singh, S.V. Activation of a novel      ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase      1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide,      a promising cancer chemopreventive constituent of processed garlic. Molecular Cancer Therapeutics, 2007      6(4): 1249-1261.
  • Faculty Profile

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