Michael G. Rossmann

Michael G.  Rossmann Profile Picture

Hanley Distinguished Professor of Biological Sciences
National Academy of Sciences; Ph.D., Glasgow (Scotland), 1956

Contact Info:


Training Group(s):
Microbiology, Immunology and Infectious Diseases
Computational and Systems Biology
Biomolecular Structure and Biophysics

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Structure and function of Viruses Cryo electron microscopy X-ray crystallography Microbiology

Selected Publications:

Liu, Y., M. G. Hill, T. Klose, Z. Chen, K. E. Watters, Y. A. Bochkov, W. Jiang, A. C. Palmenberg, M. G. Rossmann. 2016. Atomic structure of a rhinovirus C, a species linked to severe childhood asthma. Proc. Natl. Acad. Sci. U.S.A. 113:8997-9002. doi: 10.1073/pnas.1606595113; PMID: 27511920; PMCID: PMC4987780.

Fokine, A., M. G. Rossmann. 2016. Common evolutionary origin of procapsid proteases, phage tail tubes, and tubes of bacterial type VI secretion systems. Structure 24:1928-1935. doi: 10.1016/j.str.2016.08.013; PMID: 27667692; PMCID: PMC5093050.

Arisaka, F., M. L. Yap, S. Kanamaru, M. G. Rossmann. 2016. Molecular assembly and structure of the bacteriophage T4 tail. Biophys. Rev. 8:385-396. doi: 10.1007/s12551-016-0230-x.; PMID: 28510021; PMCID: PMC5418481.

Mangala Prasad, V., A. S. Miller, T. Klose, D. Sirohi, G. Buda, W. Jiang, R. J. Kuhn, M. G. Rossmann. 2017. Structure of the immature Zika virus at 9 Å resolution. Nat. Struct. Mol. Biol. 24:184-186. doi:10.1038/nsmb.3352; PMID: 28067914; PMCID: PMC5296287.

Rossmann, M. G. 2017. John C. Kendrew and his times. J. Mol. Biol. 429(17):2601-2602. doi: 10.1016/j.jmb.2017.03.012; PMID: 28315354.

Hasan, S. S., A. Miller, G. Sapparapu, E. Fernandez, T. Klose, F. Long, A. Fokine, J. C. Porta, W. Jiang, M. S. Diamond, J. E. Crowe, Jr., R. J. Kuhn, M. G. Rossmann. 2017. A human antibody against Zika virus crosslinks the E protein to prevent infection. Nat. Commun. 8:14722. doi: 10.1038/ncomms14722; PMID: 28300075; PMCID: PMC5356071.

Urakami, A., A. Sakurai, M. Ishikawa, G. Meng, Y. Flores-Garcia, Y. Haseda, T. Aoshi, F. P. Zavala, M. G. Rossmann, S. Kuno, R. Ueno, W. Akahata. 2017. Development of a novel virus-like particle vaccine platform that mimics immature form of alphavirus. Clin. Vaccine Immunol. 24(7):e00090-17. doi: 10.1128/CVI.00090-17; PMID: 28515133; PMCID: PMC5498722.

Mangala Prasad, V., T. Klose, M. G. Rossmann. 2017. Assembly, maturation and three-dimensional helical structure of the teratogenic rubella virus. PLoS Pathog. 13:e1006377. doi: 10.1371/journal.ppat.1006377; PMID: 28575072; PMCID: PMC5470745.

Andreani, J., J. Y. Bou Khalil, M. Sevvana, S. Benamar, F. DiPinto, I. Bitam, P. Colson, T. Klose, M. G. Rossmann, D. Raoult, B. La Scola. 2017. Pacmanvirus, a new giant icosahedral virus at the crossroads between Asfarviridae and Faustoviruses. J. Virol. 91(14):e00212-17. doi: 10.1128/JVI.00212-17; PMID: 28446673; PMCID: PMC5487549.

Dong, Y., Y. Liu, W. Jiang, T.J. Smith, Z. Xu, M.G. Rossmann. 2017. Antibody-induced uncoating of human rhinovirus B14. Proc. Natl. Acad. Sci. U.S.A. 114(30):8017-8022. doi: 10.1073/pnas.1707369114; PMID: 28696310; PMCID: PMC5544331.

Chen, Z., L. Sun, Z. Zhang, A. Fokine, V. Padilla-Sanchez, D. Hanein, W. Jiang, M. G. Rossmann, V. B. Rao. Cryo-EM structure of the bacteriophage T4 isometric head at 3.3Å. Proc. Natl. Acad. Sci. U.S.A. 114(39):E8184-8193. doi: 10.1073/pnas.1708483114; PMID: 28893988; PMCID: PMC5625921.

Yap, M. L., T. Klose, A. Urakami, W. Akahata, M. G. Rossmann. 2017. Structural studies of Chikungunya virus maturation. Proc. Natl. Acad. Sci. U.S.A., 114(52):13703-13707. doi: 10.1073/pnas.1713166114; PMID: 29203665; PMCID: PMC5748190.

Wang, Z., S. C. Hardies, A. Fokine, T. Klose, W. Jiang, B. C. Cho, M. G. Rossmann. Structure of the marine siphovirus TW1: evolution of the capsid stabilizing proteins and tail spikes. Structure 26(17):30400-30408. doi: 10.1016/j.str.2017.12.001; PMID: 29290487; PMCID: pending.

Sun, Y., A. P. Roznowski, J. M. Tokuda, T. Klose, A. W. Mauney, L. Pollack, B. A. Fane, M. G. Rossmann. Structural changes of tailless bacteriophage ΦX174 during penetration of bacterial cell walls. Proc. Natl. Acad. Sci. U.S.A., 114(52):13708-13713. doi: 10.1073/pnas.1716614114; PMID: 29229840; PMCID: PMC5748221.

De Castro, C., T. Klose, I. Speciale, R. Lanzetta, A. Molinaro, J.L. Van Etten, M.G. Rossmann. 2018. Structure of the chlorovirus PBCV-1 major capsid glycoprotein determined by combining crystallographic and carbohydrate molecular modeling approaches. Proc. Natl. Acad. Sci. U.S.A., 115(1):E44-E52. doi: 10.1073/pnas.1613432115; PMID: 29255015; PMCID: pending.

Hasan, S. S., M. Sevvana, R. J. Kuhn, M. G. Rossmann. 2018. Structural biology of Zika virus and other flaviviruses. Nat. Struct. Mol. Biol. 25(1):13-20. doi: 10.1038/s41594-017-0010-8; PMID: 29323278.

"Pushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions" by Dongjie Zhu, Xiangxi Wang, Qianglin Fang, James van Etten, Michael Rossmann, Zihe Rao, and xinzheng zhang [Paper #NCOMMS-18-04588A],

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