Interdisciplinary Life Science - PULSe Great research is a matter of choice

David Nolte

David Nolte Profile Picture

Distinguished Professor of Physics
Ph.D., Physics, University of California at Berkeley (1988); B.A., Physics, Cornell University (1981)

Contact Info:

Training Group(s):
Molecular Signaling and Cancer Biology

Current Research Interests:

Prof. Nolte's research interests focus on the physics of light interaction with living tissue.  His central experimental techniques include interferometry and digital holography.  Dynamic light scattering and Doppler effects carry significant information concerning the health of tissue and how they respond to applied pharmaceuticals.  To assess this information, Nolte's lab has developed Biodynamic Imaging (BDI), a 3D tissue imaging technique that combines principles of Doppler radar with principles of light microscopy.  Biodynamic imaging is currently in clinical trials for chemotherapy sensitivity and could be used in the future to select the best therapies for cancer patients sooner.

Selected Publications:

Kwan Jeong, John J. Turek & David D. Nolte, Imaging Motility Contrast in Digital Holography of Tissue Response to Cytoskeletal Anti-cancer Drugs, Optics Express 15, 14057 (2007)

D. D. Nolte, R. An, J. Turek and K. Jeong, Phenotypic Profiling of Cellular Motions in Live Tissue, Biomed. Opt. Express. 3, 2825-2841 (2012)

Ran An, Dan Merrill, Larisa Avramova, Jennifer Sturgis, Maria Tsiper, J. Paul Robinson, John Turek and David D. Nolte, Phenotypic Profiling of Raf Inhibitors and Mitochondrial Toxicity in 3D Tissue using Biodynamic Imaging, J. Biomolec. Screening, DOI: 10.1177/1087057113516674 (Dec. 20, 2013) Volume: 19 Â Â Issue: 4 Pages: 526-537, Â APR 2014

D. Merrill, R. An, J. J. Turek, D. D. Nolte, Digital Holography of Intracellular Dynamics to Probe Tissue Physiology, Appl. Opt. 54, A89-A97 (2015)

Ran An,Chunmin Wang, John Turek, Zoltan Machaty, and David D. Nolte, Biodynamic imaging of live porcine oocytes, zygotes and blastocysts for viability assessment in assisted reproductive technologies, Biomed. Opt. Exp. vol. 6, no. 3, 963-976 (2015)

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