Sulma Mohammed

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Our research focuses on (a) Characterization of an immunocompetent animal model resource for triple-negative breast cancer and investigation of immunopreventative and immunotherapeutic approaches such as vaccines and CAR T therapy; (b) Studying mechanisms of cancer dissemination through the lymphatic system; (c) Studying the biology of triple-negative breast cancer, and (d) Addressing cervical cancer inequality and development of point-of-care-test.

Selected Publications:

1. Antuofermo E, Miller MA, Pirino S, Xie J, Badve S, Mohammed SI. Spontaneous mammary intraepithelial lesions in dogs--a model of breast cancer. Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2247-56. PMID: 17982119

2. Mouser P, Miller MA, Antuofermo E, Badve SS, Mohammed SI Prevalence and classification of spontaneous mammary intraepithelial lesions in dogs without clinical mammary disease. Vet Pathol. 2010 Mar;47(2):275-84. PMID: 20106771

3. Miller MA, Mohammed SI. In pursuit of a prognostic marker in canine mammary tumors. Vet J. 2011 Sep;189(3):245. PMID: 21277242

4. Mohammed SI, Meloni GB, Pinna Parpaglia ML, Marras V, Burrai GP, Meloni F, Pirino S, Antuofermo E. Mammography and ultrasound imaging of preinvasive and invasive canine spontaneous mammary cancer and their similarities to human breast cancer. Cancer Prev Res (Phila). 2011 Nov;4(11):1790-8. PMID: 21803985

5. Burrai GP, Tanca A, De Miglio MR, Abbondio M, Pisanu S, Polinas M, Pirino S, Mohammed SI, Uzzau S, Addis MF, Antuofermo E. Investigation of HER2 expression in canine mammary tumors by antibody-based, transcriptomic and mass spectrometry analysis: is the dog a suitable animal model for human breast cancer? Tumour Biol. 2015 Nov;36(11):9083-91. PMID: 26088453

6. Mohammed SI, Utturkar S, Lee M, Yang HH, Cui Z, Atallah Lanman N, Zhang G, Ramos Cardona XE, Mittal SK, Miller MA. Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer. Cancers (Basel). 2020 Feb 11;12(2):418. PMID: 32053966.

7. Beetch M, Harandi-Zadeh S, Yang T, Boycott C, Chen Y, Stefanska B, Mohammed SI. DNA methylation landscape of triple-negative ductal carcinoma in situ (DCIS) progressing to the invasive stage in canine breast cancer. Sci Rep. 2020 Feb 12;10(1):2415. PMID: 32051475

8. Ramos-Cardona XE, Luo W, and Mohammed SI. Advances and Challenges of CAR T Therapy and Suitability of Animal Models. Molecular and Clinical Oncology. Submitted - Under review

9. Mohammed SI, Torres-Luquis O, Walls E, Lloyd F. Lymph-circulating tumor cells show distinct properties to blood-circulating tumor cells and are efficient metastatic precursors. Mol Oncol. 2019 Jun;13(6):1400-1418. PMID: 31026363.

10. Mohammed SI, Torres-Luquis O, Zhou W, Lanman NA, Espina V, Liotta L. Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis.Breast Cancer (Dove Med Press). 2020 Mar 25;12:57-67. PMID: 32273752.

11. Rahman M, Mohammed S. Breast cancer metastasis and the lymphatic system. Oncol Lett. 2015 Sep;10(3):1233-1239. PMID: 26622656

12. Tayyari F, Gowda GAN, Olopade OF, Berg R, Yang HH, Lee MP, Ngwa WF, Mittal SK, Raftery D, Mohammed SI. Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences. Oncotarget. 2018 Feb 7;9(14):11677-11690. PMID: 29545929

13. Torres-Luquis O, Madden K, N'dri NM, Berg R, Olopade OF, Ngwa W, Abuidris D, Mittal S, Lyn-Cook B, Mohammed SI. LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women. Breast Cancer (Dove Med Press). 2018 Dec 20;11:1-12. PMID: 30588086

14. Ren W, Mohammed SI, Wereley S, Irudayaraj J. Magnetic Focus Lateral Flow Sensor for Detection of Cervical Cancer Biomarkers. Anal Chem. 2019 Feb 19;91(4):2876-2884. 30632735

15. Mohammed SI, Ren W, Flowers L, Rajwa B, Chibwesha CJ, Parham GP, Irudayaraj JM. Point-of-care test for cervical cancer in LMICs. Oncotarget. 2016 Apr 5;7(14):18787-97. PMID: 26934314

16. Ginsburg O, Badwe R, Boyle P, Derricks G, Dare A, Evans T, Eniu A, Jimenez J, Kutluk T, Lopes G, Mohammed SI, Qiao YL, Rashid SF, Summers D, Sarfati D, Temmerman M, Trimble EL, Padela AI, Aggarwal A, Sullivan R. Changing global policy to deliver safe, equitable, and affordable care for women's cancers. Lancet. 2017 Feb 25;389(10071):871-880. PMID: 27814964