Interdisciplinary Life Science - PULSe Great research is a matter of choice

Russell Main

Russell Main Profile Picture

Assistant Professor of Basic Medical Sciences
Ph.D.-2006-Harvard University

Contact Info:

Training Group(s):
Molecular Signaling and Cancer Biology

Current Research Interests:

Research in the lab focuses on three primary areas within the broader theme of musculoskeletal biology and mechanics. First, we are interested in skeletal biology and changes in gene and protein regulation during growth and development. Ultimately, we strive to understand how regulation of bone at the genetic and cellular level affects skeletal structure and the ability to withstand mechanical load. Second, we study in vivo biomechanics across a wide range of vertebrate groups to measure how the musculoskeletal system is loaded by external forces during locomotion and the bearing of these forces on musculoskeletal growth an development. Third, we study musculoskeletal adaptation to applied mechanical loading and unloading. We use controlled loading conditions to relate mechanical stimuli to the skeletal response at the gene, protein, cell, and whole bone levels

Selected Publications:

Main, R.P. and A.A. Biewener. Hindlimb torsional mechanics in emu (Dromaius novaehollandiae) and other extant reptiles. Journal of Anatomy (In review).

*Lynch, M.E., *R.P. Main, Q. Xu, T.L. Schmicker, M.B. Schaffler, T.M. Wright, M.C.H. van der Meulen. Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging. Bone 49, 439-446, 2011. *authors contributed equally to this work 

Main, R.P., M.E. Lynch, and M.C.H. van der Meulen. In vivo tibial stiffness is maintained by whole bone morphology and cross-sectional geometry in growing female mice. Journal of Biomechanics 43, 2689-2694, 2010. 

Lynch, M.E., R.P. Main, Q. Xu, D.J. Walsh, M.B. Schaffler, T.M. Wright, and M.C.H. van der Meulen. Cancellous bone adaptation to dynamic tibial compression is not sex-dependent in growing mice. Journal of Applied Physiology 109, 685-691, 2010. 

Moreno, C.A, R.P. Main, and A.A. Biewener. Variability in forelimb bone strains during non-steady locomotor activities in goats. Journal of Experimental Biology 211, 1148-1162, 2008.  

Main, R.P. and A.A. Biewener. Skeletal strain patterns and growth in the emu hindlimb during ontogeny. Journal of Experimental Biology 210, 2676-2690, 2007. 

Main, R.P. Ontogenetic relationships between in vivo strain environment, bone histomorphometry, and growth in the goat radius. Journal of Anatomy 210, 272-293, 2007.

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