Julie Liu

Julie Liu Profile Picture

Associate Professor
California Institute of Technology

Contact Info:

julieliu@purdue.edu
765-494-1935
FRNY 1160
engineering.purdue.edu/LiuGroup

Training Group(s):
Biotechnology

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Prof. Liu's research focuses on developing protein-based biomaterials for application in tissue engineering, regenerative medicine, and surgical glues. One area of investigation is in designing biomaterials from recombinant proteins. Recombinant proteins have molecular-level control over amino acid sequence, a property that dictates the subsequent structure and function. To fully utilize the potential of these biomaterials, her work focuses on establishing key sequence-structure-function relationships between protein design and the resulting material properties. Another area of investigation is the use of natural proteins, such as collagen, and other important matrix molecules, such as hyaluronic acid and chondroitin sulfate. In addition to being biomimetic, these materials contain important biological cues that govern cell response. Overall, the Liu group utilizes both recombinant proteins and natural matrix molecules to design materials with specific performance capabilities for cartilage engineering, in vitro tissue models for drug testing, and biomedical adhesives.

Selected Publications:

C.E. Kilmer, T. Walimbe, A. Panitch, J.C. Liu, “Incorporation of a Collagen-Binding Chondroitin Sulfate Molecule to a Collagen Type I and II Blend Hydrogel for Cartilage Tissue Engineering,” ACS Biomaterials Science & Engineering, 8, 1247-1257 (2022).

S. Hollingshead, J.E. Torres, J.J. Wilker, and J.C. Liu, “Effect of Cross-Linkers on Mussel- and Elastin-Inspired Adhesives on Physiological Substrates,” ACS Applied Bio Materials, 5, 630-641 (2022).

S. Hollingshead, H. Siebert, J.J. Wilker, and J.C. Liu, “Cytocompatibility of a Mussel-Inspired Poly(Lactic Acid)-Based Adhesive,” Journal of Biomedical Materials Research: Part A, 110, 43-51 (2022).

C.-Y. Lin, C.M. Battistoni, and J.C. Liu, “Redox-Responsive Hydrogels with Decoupled Initial Stiffness and Degradation,” Biomacromolecules, 22, 5270-5280 (2021).

M. Nguyen, J.C. Liu, and A. Panitch, “Physical and Bioactive Properties of Glycosaminoglycan Hydrogels Modulated by Polymer Design Parameters and Polymer Ratio,” Biomacromolecules, 22, 4316-4326 (2021).

Q. Xu, J.E. Torres, M. Hakim, P.M. Babiak, P. Pal, C.M. Battistoni, M. Nguyen, A. Panitch, L. Solorio, and J.C. Liu, “Collagen- and Hyaluronic Acid-based Hydrogels and their Biomedical Applications,” Materials Science & Engineering: R: Reports, 146, 100641 (2021).

C.-Y. Lin and J.C. Liu, “Comparison between Catechol- and Thiol-based Adhesion Using Elastin-like Polypeptides,” ACS Applied Bio Materials, 3, 3894-3905 (2020).

C.E. Kilmer, C.M. Battistoni, A. Cox, G.J. Breur, A. Panitch, and J.C. Liu, “Collagen Type I and II Blend Hydrogel with Autologous Mesenchymal Stem Cells as a Scaffold for Articular Cartilage Defect Repair,” ACS Biomaterials Science & Engineering, 6, 3464-3476 (2020).

M.J. Brennan, B.F. Kilbride, J.J. Wilker, and J.C. Liu, “A Bioinspired Elastin-based Protein for a Cytocompatible Underwater Adhesive,” Biomaterials, 124, 116-125 (2017).

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