Mark A. Lipton

Mark A.  Lipton Profile Picture

Associate Professor — Organic Chemistry
Ph.D., 1988, Columbia University

Contact Info:

Training Group(s):
Chemical Biology

PULSe Contributor - not currently hosting students for laboratory rotations or recruiting students in the laboratory

Current Research Interests:

Our research effort combines the disciplines of organic synthesis, bioorganic chemistry and molecular modeling. Current projects in the Lipton group fall into two areas:

Development of novel synthetic methodology.We have recently developed two new reagents for the guanylation of amines, an important and underdeveloped reaction. We also have developed a novel, cyclic dipeptide catalyst (1) for an asymmetric variant of the Strecker amino acid synthesis. This has led to a broad effort directed toward the use of cyclic dipeptide catalysts (e.g., 2) in asymmetric carbon-carbon bond forming reactions. We have initiated another broad effort in the area of reactions on solid supports. We began with the synthesis of cyclic dipeptides 1 and 2 for our catalysis studies. Recent projects involve the synthesis of peptidomimetics (e.g., 3) and macrocyclic lactams on solid supports.

Design and synthesis of biologically active molecules.Ongoing projects include the synthesis of inhibitors of the enzymes cyclophilin A and HIV-1 protease (both essential for the replication of the HIV-1 virus and the pathogenesis of AIDS), and novel DNA-cleaving agents for the treatment of cancer. Projects of this type usually are designed using molecular modeling and tested "in house" after synthesis


Selected Publications:

M.S Iyer, N. Namdev, K. Gigstad, and M.A.Lipton, "Asymmetric Catalysis of the Strecker Synthesis by a Cyclic Dipeptide," J. Am. Chem. Soc. 1996, 118, 4910-491.

J. Kowalski and M.A. Lipton, "Solid Phase Sythesis of a Diketopiperazine Catalyst Containing the Unnatural Amino Acid (S)-Norarginine." Tetrahedron Lett. 1996, 37, 5839-5840.

Y.F. Yong, J.A. Kowalski, M.A. Lipton, "The Facile and Efficient Guanylation of Amines Using Thioureas and Mukaiyama's Reagent," J. Org. Chem. 1997, 62, 1540-1542.

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