Casey Krusemark

Casey Krusemark Profile Picture

Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Ph.D., Univ. of Wisconsin Madison (Peter Belshaw), 2007
Postdoctoral Fellow, Stanford Univ. (Pehr Harbury/Patrick Brown), 2007-2013

Contact Info:

Training Group(s):
Cancer Biology
Chemical Biology

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

            Research in the Krusemark laboratory is focused on the discovery of functional small molecules using the power of in vitro evolution.  DNA-programmed combinatorial chemistry (DPCC) enables the "translation" of DNA constructs into DNA conjugates with wholly synthetic small molecules, thus enabling Darwinian-like selections. DPCC allows the synthesis and functional interrogation of small molecule libraries of unprecedented size and complexity (presently up to 1010 members).  

            The Krusemark lab works on the further development of the DPCC technology, towards the goal of a streamlined system for generating drug leads and biological tool compounds.  We use a combination of chemical, engineering, and molecular biology methods. We are working to expand the synthetic toolbox available for building molecules on unprotected DNA towards drug-like small molecules.   Our lab will develop tools to study the protein kinase C (PKC) family of kinases, which are involved in the signal transduction pathways of numerous and varied cellular processes.  

Selected Publications:

Krusemark, C. J., Tilmans, N. P., Brown, P. O., Harbury, P. B., "Quantitative Population Behavior in the Directed Chemical Evolution of Protein Kinase Substrates." In review.Tilmans, N. P., Krusemark, C. J., Harbury, P. B., “Expedient Synthesis of a Modular Phosphate Affinity Reagent.” Bioconj. Chem.  2010, 21, 1010-1013.

Krusemark, C. J., Frey, B. L., Belshaw, P. B., Smith, L. M., "Modifying the Charge State Distribution of Proteins in Electrospray Ionization Mass Spectrometry by Chemical Derivatization." J. Am. Soc. Mass Spectrom.  2009, 20, 1617-1625.

Krusemark, C. J., Ferguson, J. T., Wenger, C. D., Kelleher, N. L., Belshaw, P. J., "Global Amine and Acid Functional Group Modification of Proteins."  Analytical Chemistry.  2008, 80, 713-720.

 Krusemark, C. J. and Belshaw, P. J., "Covalent Labelling of Fusion Proteins in Live Cells via an Engineered Receptor-Ligand Pair."  Organic and Biomolecular Chemistry. 2007, 5, 2201-2204.

Lamos, S. M.*, Krusemark, C. J.*, McGee, C. J., Scalf, M., Smith, L. M., Belshaw, P. J.,  "Mixed Isotope Photoaffinity Reagents for Identification of Small Molecule Targets by Mass Spectrometry."  Angewandte Chemie Int. Ed. 2006, 45, 4329-4333.

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