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Chang H. Kim

Chang H. Kim Profile Picture

Professor of Immunology
Ph.D. (Indiana University School of Medicine); Fellowship (Stanford University)

Contact Info:

Training Group(s):
Immunology and Infectious Diseases
Molecular Signaling and Cancer Biology

Current Research Interests:

Hematopoiesis, differentiation, migration and function of immune cells: Immune cells in our bodies develop immunity against pathogens and cancer. Immune cells are produced from stem and progenitor cells that are present mainly in the bone marrow. Many subsets of T cells play central roles in regulation of immune responses. Immune cells migrate from the thymus to lymph nodes and then to sites of infection and cancer for differentiation and effector functions. We study the mechanisms of trafficking and effector function of immune cells and differentiation of stem and progenitor cells. Current studies in the lab include: 1) Roles of chemokines and chemokine receptors in trafficking of immune cells (focusing on FoxP3+ cells and Th17 cells); 2) migration of T cell subsets in cancer; 3) migration and function of regulatory T cells in autoimmune diseases such as Crohn's disease; 4) Functional genomics of germinal center T cells; 5) Regulation of immune responses at the mucosal surface; and 5) Homing and differentiation of hematopoietic stem cells.

Selected Publications:

Kim CH, Qu C, Hangoc G, Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.

Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP. 1999, J. Clin. Invest. 104:1751

Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.

Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.

Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.

Kim CH, Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo. 2001, J. Clin. Invest, 108:1331

Kim CH and Butcher EC, Trafficking machinery of NKT cells: differential chemokine receptor expression among NKT cell subsets with distinct cytokine-producing capacity. 2002, Blood. 2002;100:11-16.

Roy M, Kim CH, Butcher EC. Cytokine regulation of B cell homing machinery. 2002, J. Immunol. 169:1676.

Kim CH, Nagata K, and Butcher EC. Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation. J. Immunol. 2003. 171:152-158.

Broxmeyer HE, Cooper S. Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, and Kim CH. Transgenic Expression of Stromal Cell Derived Factor-1/CXCL12 Enhances Myeloid Progenitor Cell Survival/Anti-Apoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo. 2003, J. Immunol.,170:421-9.

Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T cells. 2004. Blood. 104: 1952-1960.

Lim HW, Hillsamer P, Kim CH. Regulatory T cells acquire migratory capacity to follicles upon T cell activation and suppress GC-T helper cell-driven B cell responses. 2004, J. Clin. Invest. 114:1640-1649.

Kim CH. The greater chemotactic network for lymphocyte trafficking: Chemokines and beyond. Current Opinion in Hematology 2005, 12:298-304.

Kim CH. Chemokines and their receptors in hematopoietic cell development and function. In Chemokines, Chemokine Receptors, and Disease. Edited by Lisa Schwiebert. Current Topics in Membranes (Elsevier. 2005), 55:115-142.

Kim JR, Lim HW, Hillsamer P, Kim CH. Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination. BMC Immunology 2005, 6:3.

Broxmeyer HE, Cooper S, Hangoc G, Kim CH. Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. 2005. Stem Cells Dev. 14: 199-203.

Lim HW, Hillsamer P, Banham AH, and Kim CH , Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells , J Immunol 2005 175: 4180-4183

Kim CH. Regulation of humoral immunity by FoxP3+ regulatory T cells. Expert Review of Clinical Immunology, 2006. Vol. 2(6): 859-868

Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box p3+ regulatory T cells. J Immunol. 2006 177(2):840-51.

Kim CH. Trafficking of FoxP3+ Regulatory T cells: Myths and Facts. Arch. Immunol. Ther. Exp., 2007, 55, 1–9

Kim CH. Molecular Targets of FoxP3+ Regulatory T cells. Mini Rev Med Chem. 2007, 11:1136-43.

Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311.

Kang SG, Piniecki RJ, Lim HW, HogenEsch H, Braun SE, Wiebke E, Matsumoto S, Kim CH. Identification of a chemokine network that recruits FoxP3+ regulatory T cells to inflamed intestine. Gastroenterology, 2007, 132: 966-981.

Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, and Kim CH. Vitamin A Metabolites Induce Gut Homing FoxP3+ Regulatory T cells. J Immunol 2007. 179: 3724-3733.

Lim HW, Kim CH. Loss of IL-7Ralpha defines terminally differentiated B cell helping effector T cells. J Immunol, 2007 179: 7448-7456.

Lim HW, Lee J, Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008 Jan 1;180(1):122-9.

Wang C, Kang SG, Lee J, Sun Z, Kim CH. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2009 Mar;2(2):173-83

Kang SG, Wang C, Matsumoto S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T cell subsets and effectively control intestinal inflammation. Gastroenterology. 2009 Oct;137(4):1391-402.

Lee JH, Wang C, Kim CH. FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells. J Immunol. 2009 Nov 15;183(10):6377-86.

Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH, Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010 Apr 26.

Wang C, Kang SG, Hogenesch H, Love PE, Kim CH. Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine. J Immunol. 2010, 184, 5519 -5526

Kang SG, Park J, Cho JY, Ulrich B, Kim CH. Complementary roles of retinoic acid and TGF-ß1 in coordinated expression of mucosal integrins by T cells. Mucosal Immunol. 2011 Jan;4(1):66-82. Epub 2010 Jul 21.

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