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T. Joseph Kappock

T. Joseph Kappock Profile Picture

Assistant Professor of Biochemistry
PhD, Yale University, 1996

Contact Info:

Training Group(s):
Chemical Biology

Current Research Interests:

Mechanisms of carbon-carbon bond forming enzymes citrate synthase and PurE; metabolic bases of acetic acid resistance in acidophilic bacteria.

Selected Publications:

Kurz, L. C., C. Z. Constantine, H. Jiang, & T. Kappock (2009). The partial substrate dethiaacetyl-coenzyme A mimics all critical carbon acid reactions in the condensation half-reaction catalyzed by Thermoplasma acidophilum citrate synthase. Biochemistry, 48(33), 7878-7891.

Mullins, E. A., Francois, J. A., and Kappock, T. J. (2008) A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti. J. Bacteriol. 190, 4933-4940.

Schaefer, J., Jiang, H., Ransome, A. E., and Kappock, T. J. (2007) Multiple active site histidine protonation states in Acetobacter aceti N5-carboxyaminoimidazole ribonucleotide mutase (PurE) detected by REDOR NMR. Biochemistry 46, 9507-9512.

Nam, J.-W., and Kappock, T. J. (2007) Cloning and transcriptional analysis of Crepis alpina fatty acid desaturases affecting the biosynthesis of crepenynic acid. J. Exp. Bot. 58, 1421-1432.

Constantine, C. Z., Starks, C. M., Mill, C. P., Ransome, A. E., Karpowicz, S. J., Francois, J. A., Goodman, R. A., and Kappock, T. J. (2006) Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase (PurE) from the acidophilic bacterium Acetobacter aceti. Biochemistry 45, 8193-8208.

Francois, J. A., Starks, C. M., Sivanuntakorn, S., Jiang, H., Ransome, A. E., Nam, J.-W., Constantine, C. Z., and Kappock, T. J. (2006) Structure of an NADH-insensitive hexameric citrate synthase that resists acid inactivation. Biochemistry 45, 13487-13499.

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