Interdisciplinary Life Science - PULSe Great research is a matter of choice

Joseph M K Irudayaraj

Joseph M K Irudayaraj Profile Picture

M.S. (Biosystems Engineering); M.S. (Computer Sciences); Ph.D. (Biological Engineering)

Contact Info:

Training Group(s):
Chromatin and Regulation of Gene Expression

Current Research Interests:

Our focus is to develop nanotools for real time diagnostics and single molecule methods to understand intracellular mechanisms that could potentially lead to the development of efficient therapies or better prognosis of cancer or neurodegenerative diseases. Single molecule methods as tools for understanding, asking, and answering fundamental biological questions, related to epigenetic modifications and programming, phosphorylation dynamics, splice profiling and mRNA trafficking are central to our work.

Selected Publications:

1. Chen, J., Wang, C., and Irudayaraj, J. 2009. Ultrasensitive on-step immunoassay in blood serum using gold nanoparticle probes by single molecule spectroscopy. Biomedical Optics Letters, July/August issue, Vol 14,(4). 1-4. 040501:1-3.

2. Chen, J. and Irudayaraj, J. 2009. Quantitative investigation of compartmentalized dynamics of ErbB2 targeting gold nanorods in live cells by single molecule spectroscopy. ACS Nano (conditionally accepted)

3. Sun, L. and Irudayaraj, J. 2009. Quantitative Surface Enhanced Raman for gene expression estimation, Biophysical Journal. 96:4609-16.

4. Wang, C. Chen, J. Talavange, T. and Irudayaraj, J. 2009. Gold nanorod/Fe3O4 nanoparticle "Nano-Pearl-Necklaces" for simultaneous targeting, dual-mode imaging, and photothermal ablation of cancer cells. Angewandte Chemie, 121(15):2797-2801.

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