Interdisciplinary Life Science - PULSe Great research is a matter of choice

Kevin M. Hannon

Kevin M. Hannon Profile Picture

Assistant Professor of Basic Medical Sciences
Ph.D. - 1990 - Iowa State University

Contact Info:

Training Group(s):
Molecular Signaling and Cancer Biology

Current Research Interests:

Skeletal muscle atrophy, a decrease in muscle size and strength, is a sequela of many different diseases and states (e.g., cancer, heart disease and stroke, and aging). Atrophy progressively robs a person of his/her ambulatory function, thereby markedly diminishing the quality of life of millions of Americans each year. Age-associated atrophy often necessitates costly nursing care, and disease-associated atrophy both increases hospitalization time and extends requirements for regenerative therapy. Thus, in addition to quality of life issues, skeletal muscle atrophy is an important factor that drives up the cost of medical care. The long-range goal of our laboratory is to discover potential treatments and interventions for skeletal muscle atrophy. To date, we have found specific growth factors that stimulate the growth, size and strength of skeletal muscles in vivo. It is expected that these growth factors will provide the means to prevent and/or treat skeletal muscle atrophy associated with aging and disease. In addition, we have identified growth factors that significantly inhibit the growth of, and actually stimulate degeneration of, skeletal muscle in vivo. In order to design the most optimal approaches for the prevention and treatment of skeletal muscle atrophy, it may be necessary to consider inhibiting mechanisms that are responsible for myofiber degeneration.

Selected Publications:

Mitchell, P., T. Steenstrup, and K. Hannon. 1999. Expression of FGFs during post-natal skeletal muscle hypertrophy. J. Appl. Phys.. 86: 313-319.

Steenstrup, T. and K. Hannon. 2000. Fusion alters mitogenic response of BC3H1 muscle cells. In Vitro Developmental Biology 36: 241-248.

Flanagan-Steet*, H., K. Hannon*, M. McAvoy, R. Hullinger, B. B. Olwin. 2000. Loss of FGF Receptor 1 Signaling Reduces Skeletal Muscle Mass and Disrupts Myofiber Organization in the Developing Limb. Developmental Biology 218: 21-37. (*indicates equal contributors, listed alphabetically).

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