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Jessica Ellis

Jessica Ellis Profile Picture

Assistant Professor, Department of Nutrition Science
Ph.D. Nutritional Biochemistry, University of North Carolina at Chapel Hill

Contact Info:

Training Group(s):
Membrane Biology

Current Research Interests:

Abnormally high levels of fat metabolism, particularly in the muscle, play a key role in the development of diabetes and diabetes-related heart disease. The lab aims to target the breakdown of fats in the muscle and heart to prevent and improve diabetes and related complications. These goals will be accomplished using novel conditional genetic animal models combined with dietary and exercise paradigms, as well as biochemical and molecular techniques. The long-term goal of this work is to provide mechanistic insight into the metabolic underpinnings of diabetes and ultimately shape therapeutic strategies aimed at reversing insulin resistance and preventing diabetes-related mortality.

Selected Publications:

Ellis JM, Bowman CE, Wolfgang MJ. Metabolic and tissue-specific regulation of acyl-CoA metabolism. PLoS One. 2015 10(3)e0116587. PMID: 25760036

Schisler JC, Grevengoed TJ, Pascual F, Cooper DE, Ellis JM, Paul DS, Willis MS, Patterson C, Jia W, Coleman RA. Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mTOR. J Am Heart Assoc. 2015 4(2)e001136. PMID: 25713290

Lee J, Ellis JM, Wolfgang MJ. Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress induced inflammation. 2015 Cell Reports. 2015 10(2)266-79. PMID: 25578732

Paul DS, Grevengoed TJ, Pascual F, Ellis JM, Willis MS, Coleman RA. Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin. Biochim Biophys Acta. 2014 1841(6):880-7. PMID: 24631848

Rodriguez S, Ellis JM, Wolfgang MJ. Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle. BMC Biochem 2014 15(1):20. PMID: 25152047

Ellis JM, Wong GW & Wolfgang MJ. Acyl Coenzyme A Thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol 2013; 33(9): 1869-1882. PMID: 2345998

Ellis JM & Wolfgang MJ. A genetically encoded metabolite sensor for malonyl-CoA. Chem Biol 2012 Oct; 19(10): 1333-1339. PMID: 23102226

Ellis JM, Mentock SM, DePetrillo MA, Koves TR, Sen S, Watkins SM, Muoio DM, Cline GW, Taegtmeyer H, Shulman GI, Willis MS & Coleman RA. Mouse cardiac Acyl Coenzyme A synthetase 1 deficiency impairs fatty acid oxidation and induces cardiac hypertrophy. Mol Cell Biol. 2011 Mar;31(6): 1252-62. PMID: 21245374

Ellis JM, Li LO, Wu PC, Koves TR, Stevens RD, Watkins SM, Muoio DM & Coleman RA. Adipose acyl-CoA synthetase-1 (ACSL1) directs fatty acids towards ß-oxidation and is required for cold thermogenesis. Cell Metab. 2010 Jul 4;12(1): 53-64. PMID: 20620995

Ellis JM, Frahm JL, Li LO & Coleman RA. Acyl-CoA synthetases in metabolic control. Curr Opin Lipidol 2010; 21 (3): 212-17. PMID: 20480548

Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller GN, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI & Coleman RA. Liver-specific loss of long-chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation, and alters phospholipid fatty acid composition. J. Biol Chem 2009; 284 (41): 27816-26. PMID: 19648649

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