Qing Deng

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Our lab is interested in the mechanisms that regulate neutrophil migration and activation, more specifically their response to tissue injury and infection. The neutrophil is a hallmark of inflammation and neutrophilic inflammation, if not properly resolved, is the driving force behind a spectrum of human inflammatory diseases. Hopefully, our understanding of neutrophilic inflammation will help alleviate diseases such as arthritis, cancer and auto-inflammation. We are also interested in understanding pathogen-host interactions using zebrafish model and the strength relies on the combination of the genetics in both systems. We want to create a lab where happy scientists do solid science.

Selected Publications:

Development and Characterization of an Endotoxemia Model in Zebra Fish. Hsu AY, Gurol T, Sobreira TJP, Zhang S, Moore N, Cai C, Zhang ZY, Deng Q. Front Immunol. 2018 Mar 29;9:607. doi: 10.3389/fimmu.2018.00607. eCollection 2018.

Neutrophil-specific knockout demonstrates a role for mitochondria in regulating neutrophil motility in zebrafish. Zhou W, Cao L, Jeffries J, Zhu X, Staiger CJ, Deng Q. Dis Model Mech. 2018 Mar 28;11(3).

MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Zhou W, Pal AS, Hsu AY, Gurol T, Zhu X, Wirbisky-Hershberger SE, Freeman JL, Kasinski AL, Deng Q. Cell reports. 2018; 22(7):1810-1823.

Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish. Hsu AY, Wang D, Gurol T, Zhou W, Zhu X, Lu HY, Deng Q. Disease models & mechanisms. 2017; 10(11):1323-1332.

Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Cell reports. 2017; 19(8):1572-1585.

Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, Deng Q, Keller NP, Huttenlocher A. Journal of immunology (Baltimore, Md. : 1950). 2016; 197(12):4780-4790.

EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5. Zhang Q, Wang D, Jiang G, Liu W, Deng Q, Li X, Qian W, Ouellet H, Sun J. Scientific reports. 2016; 6:32618. 

MicroRNAs in neutrophils: potential next generation therapeutics for inflammatory ailments. Gurol T, Zhou W, Deng Q. Immunological reviews. 2016; 273(1):29-47.

Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton. Zhou W, Hsu AY, Wang Y, Syahirah R, Wang T, Jeffries J, Wang X, Mohammad H, Seleem MN, Umulis D, Deng Q. J Cell Sci. 2020 Sep 4;133(17):jcs248880. doi: 10.1242/jcs.248880.

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. Hsu AY, Wang D, Liu S, Lu J, Syahirah R, Bennin DA, Huttenlocher A, Umulis DM, Wan J, Deng Q. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18561-18570. doi: 10.1073/pnas.1905221116. Epub 2019 Aug 26.

Full List on PubMed: https://www.ncbi.nlm.nih.gov/myncbi/qing.deng.1/bibliography/42120085/public/