Chad Carroll

Chad Carroll Profile Picture

Assistant Professer

Contact Info:

carrol71@purdue.edu
(765) 496-6002
Office: LAMB07

Training Group(s):
Biotechnology

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

The long-term goal of our research program is determine the molecular mechanisms contributing to the development of tendinopathies in order to develop effective treatment strategies. We are determining the mechanisms responsible for the increase in tendinopathy risk in diabetic patients and older adults. We are particularly interested in: 1) the role of advanced glycation end-products in the development of diabetic tendinosis, 2) the role of estrogen in tendon health, and 3) how a combined nutrition/exercise approach can improve tendon properties in older adults. My laboratory uses both human and rodent models to address our research goals in a bench-to-bedside manner.

Selected Publications:

Dickinson, JM, D’Lugos, AC, Naymik, M, De Both, M, Siniard, A, Wolfe, A, Curtis, D, Gaesser, GA, Huentelman, MJ, and Carroll, CC. Transcriptional signatures of human skeletal muscle in response to aerobic and resistance exercise. J Appl Physiol (1985). 2018 Mar 15. doi: 10.1152/japplphysiol.00014.2018. PMID: 29543133.

Patel, SH, Sabbaghi, A, and Carroll CC. Streptozotocin-induced diabetes alters mRNA expression of ECM regulators in rat patellar tendon. Connect Tissue Res. 2018 May 10:1-11. doi: 10.1080/03008207.2018.1470168. PMID: 29745261.

Astill, BD, Katsma, MS, Cauthon, DJ, Greenlee, J, Murphy, M, Curtis, D, and Carroll, CC. Sex-based difference in Achilles tendon release of matrix metalloproteinases and growth factors after acute resistance exercise. J Appl Physiol (1985). 2017 Feb 1;122(2):361-367. doi: 10.1152/japplphysiol.00878.2016. Epub 2016 Nov 23. PMID: 27881671.

Katsma, MS, Patel, SH, Eldon, ER, Arthur, KA, Shimkus, KL, Fluckey, JD., and Carroll, CC. The influence of chronic IL-6 exposure, in vivo, on rat Achilles tendon extracellular matrix. Cytokine, 2017 May;93:10-14. doi: 10.1016/j.cyto.2017.04.011. Epub 2017 Apr 13. PMID: 28412025.

Patel, SH, D’Lugos, AC, Eldon, ER, Curtis, D, Dickinson, JM, and Carroll, CC. Impact of acetaminophen consumption and resistance exercise on extracellular matrix gene expression in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2017 2017 Jul 1;313(1):R44-R50. doi: 10.1152/ajpregu.00019.2017. Epub 2017 May 17. PMID: 28515079.

Dickinson, JM, D’Lugos, AC, Mahmood, TM, Ormsby, J, Salvo, L, Dedmon, WL, Patel, SH, Katsma, MS, Gonzales, RJ, Hale, TM, Carroll, CC*, Angadi, SS*. Exercise protects skeletal muscle during chronic doxorubicin administration. *Denotes equal contribution of authors. Med Sci Sport Exerc. 2017 Dec;49(12):2394-2403. PMID:28767526

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