Arun K. Bhunia

Arun K. Bhunia Profile Picture

Professor of Molecular Food Microbiology
B.V.Sc (Veterinary Medicine), W.B. India; Ph.D. (Food Microbiology), University of Wyoming, Laramie, WY; Postdoctoral training, University of Arkansas, Fayetteville, AR.

Contact Info:

bhunia@purdue.edu
765-494-5443
NLSN
https://ag.purdue.edu/foodsci/Pages/profile.aspx?strAlias=bhunia&intDirDeptID=14

Training Group(s):
Microbiology, Immunology and Infectious Diseases

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Microbial pathogenesis, host immune response, and bioengineered probiotics approach in mitigating foodborne pathogen infection

Selected Publications:

Drolia, R., and Bhunia, A.K. 2019. Crossing the Epithelial Barrier via Listeria Adhesion Protein and Internalin A, Trends Microbiol. 27 (5): 408-425.

Mathipa, M., Thantsha, M.S., and Bhunia, A.K., 2019. Lactobacillus casei expressing internalins A and B reduces Listeria monocytogenes interaction with Caco-2 cells in vitro. Microb. Biotechnol. 12(4):715-729.

Drolia, R., Tenguria, S., Durkes, A.C., Turner, J.R. and Bhunia, A.K. 2018. Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation. Cell Host & Microbe 23(4): 470-480.e7.

Horn, N and Bhunia, A.K. 2018. Food-Associated Stress Primes Foodborne Pathogens for the Gastrointestinal Phase of Infection.Front. Microbiol. 9:1962.

Kim, H., and Bhunia, A.K. 2013. Secreted Listeria adhesion protein (Lap) influences Lap-mediated Listeria monocytogenes paracellular translocation through epithelial barrier. Gut Pathog. 5:16.

Koo, O.K., Amalaradjou, M.A.R., and Bhunia, A.K. 2012. Recombinant probiotic expressing Listeria adhesion protein attenuates Listeria monocytogenes virulence in vitro. PLoS ONE 7 (1):e29277

Jagadeesan, B., Fleishman Littlejohn, A.E., Amalaradjou, M.A.R., Singh, A.K., Mishra, K., La, D., Kihara, D., and Bhunia, A.K. 2011. N-terminal Gly224–Gly411 domain in Listeria Adhesion Protein interacts with host receptor Hsp60. PLoS ONE 6 (6):e20694.

Burkholder, K.M. and Bhunia, A.K. 2010. Listeria monocytogenes uses LAP to promote bacterial transepithelial translocation, and induces expression of LAP receptor Hsp60. Infect. Immun. 78(12):5062-5073.

Jagadeesan, B., Koo, O.K., Kim, K.-P., Burkholder, K.M., Mishra, K.K., Aroonnual, A., and Bhunia, A.K. 2010. LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species. Microbiology-UK. 156 (9):2782–2795.

BOOKS

Foodborne Microbial Pathogens: Mechanisms and Pathogenesis, A.K. Bhunia, 1st Edition (Dec 2007), Springer, New York.

Fundamental Food Microbiology, Bibek Ray and Arun Bhunia, 4th Edition (2007).CRC Press, Boca Raton, FL.

Foodborne Pathogens: Microbiology and Molecular Biology, 2005. Editors: P. M. Fratamico, A.K. Bhunia and J.L. Smith, Caister Academic Press, Ltd., Norfolk, UK.

PATHOGENESIS

Akin, D., J. Sturgis, K. Ragheb, D. Sherman, K. Burkholder, J.P. Robinson, A.K. Bhunia, S. Mohammed, and R. Bashir. 2007. Bacteria-mediated delivery of nanoparticles into cells. Nat. Nanotechnol. 2:441-449.

Kim, K.P., B.K. Hahm, and A.K. Bhunia. 2007. The 2-cys peroxiredoxin deficient Listeria monocytogenes displays impaired growth and survival in the presence of hydrogen peroxide in vitro but not in mouse organs. Curr. Microbiol. 54:382-387.

Kim, K.-P., B. Jagadeesan, K. Burkholder, Z.W. Jaradat, J.L. Wampler, A.A. Lathrop, M.T. Morgan, and A.K. Bhunia. 2006. Adhesion characteristics of Listeria adhesion protein (LAP) expressing Escherichia coli to Caco-2 cells and of recombinant LAP to eukaryotic receptor Hsp60 as examined in a surface plasmon resonance sensor. FEMS Microbiol. Lett. 256:324-332.

Wampler, J.L., K-P. Kim, Z.W. Jaradat, and A.K. Bhunia. 2004. Heat-shock protein 60 acts as a receptor for the Listeria adhesion protein in Caco-2 cells. Infect. Immun. 72:931-936

Jaradat, Z.W., J. L. Wampler, and A.K. Bhunia. 2003. A Listeria adhesion protein-deficient Listeria monocytogenes strain shows reduced adhesion primarily to intestinal cell lines. Med. Microbiol. Immunol. 192:85-91.

Jaradat, J.W. and A.K. Bhunia. 2003. Adhesion, Invasion, and translocation characteristics of Listeria monocytogenes serotypes in a Caco-2 cell and mouse model. Appl. Environ. Microbiol. 69:3640-3645.

DETECTION

Banada, P.P., S. Guo, B. Bayraktar, E. Bae, B. Rajwa, J. Paul Robinson, E.D. Hirleman, and A.K. Bhunia. 2007. Optical forward scattering for detection of Listeria monocytogenes and other Listeria species. Biosens. Bioelectron. 22:1664-1671.

Banerjee, P., M.T. Morgan, J.L. Rickus, K. Ragheb, C. Corvalan, J. P. Robinson, and A.K. Bhunia. 2007. Hybridoma Ped-2E9 cells cultured under modified conditions can sensitively detect Listeria monocytogenes and Bacillus cereus. Appl. Microbiol. Biotechnol. 73:1423-1434.

Hahm, B. K and A.K. Bhunia. 2006. Effect of environmental stresses on antibody-based detection of Escherichia coli O157:H7, Salmonella enterica serotype Enteritidis and Listeria monocytogenes. J. Appl. Microbiol. 100:1017-1027.

Gray, K. M., P. P. Banada, E. O’Neal, and A. K. Bhunia. 2005. Rapid Ped-2E9 cell-based cytotoxicity analysis and genotyping of Bacillus species. J. Clin. Microbiol. 43:5865-5872.

Maldonado, Y., J. Fiser, C. H. Nakatsu, and A.K. Bhunia. 2005. Cytotoxicity potential and genotypic characterization of Escherichia coli isolates from environmental and food sources. Appl. Environ. Microbiol. 71:1890-1898.

Geng, T., M.T. Morgan, and A.K. Bhunia. 2004. Detection of low levels of Listeria monocytogenes cells by using a fiber-optic immunosensor. Appl. Environ. Microbiol. 70:6138-6146.

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