Molecular Signaling and Cancer Biology
Research includes:
- Apoptosis
- Cancer Biology
- Cell Cycle
- Cell Differentiation
- Cell Proliferation
- Chemokines
- Growth Factors
- Lipid Mediators
- Oncogenes
- Phosphoproteomics
- Protein Kinases
- Protein Phosphatases
- Protein Phosphorylation
- Signal Transduction
- Suppressor Genes
- Therapeutic Targets in Cancer
- Transcription Factors
Training Group Mission:
The mission of the Molecular Signaling and Cancer Biology Training Group is to educate the next generation of biomedical scientists in the understanding of the basic processes of molecular signal transduction. This knowledge will be applied to the study of differentiation, development, apoptosis and growth of normal and abnormal (malignant) cells and the treatment of disease states, with a special emphasis on cancer. The group encourages and facilitates development of integrated, interdisciplinary approaches by promoting interactions with faculty representing research areas such as cancer biology, cancer pharmacology, biomedical engineering, and chemical biology. The Training Group provides opportunities for development of independent and critical thinking skills by fostering participation in scientific seminars and research forums and will provide specialized graduate courses in the areas of Signal Transduction and the Molecular Basis of Cancer. These opportunities provide students with a strong foundation in biochemistry, molecular and cellular biology, and cancer biology preparing them for a wide range of career opportunities in academia and industry.
Faculty Membership
Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation
Epigenetic mechanisms in liver cancer pathogenesis due to chronic infection with the Hepatitis B Virus.
Obesity is associated with an increased risk of and/or mortality from several forms of cancer, including breast and colon cancer. Given that obesity rates in the U.S. are now approaching 40%, the development of mechanism-based interventions for this population could have a significant impact on public health. My research program focuses on investigating the molecular mechanisms linking obesity with increased breast and colon cancer risk and progression, with the goal of developing dietary and pharmaceutical interventions that reduce risk and improve prognoses in the obese patient population.
Chemical Immunology: Cell specific chemical perturbation of immune microenvironments in cancer, neurological and immunological disorders
Our laboratory develops strategies that can leverage the immune system to simultaneously repair bone and control inflammation or cell viability. The overall
therapy goals are to (a) treat tumors and repair bone in tumor models and (b) treat and repair cartilage/bone in arthritis models.
The Hall lab is generally interested in mechanisms cell cycle control that protect genome stability. Our work provides insight into how normal cells maintain genome fidelity during the complex process of cell division and how defects in the regulation of cell division can lead to various forms of genome instability and disease, including cancer.
Immunotherapy, A regulatory mechanism of anti-tumor immunity, A resistance mechanism of target therapy and/or immunotherapy, Antibody engineering
Understanding the regulation of phospholipase C enzymes in cardiovascular disease and cancer through macromolecular structure determination and functional assays.
In the Parkinson lab, we focus on the discovery of novel antibiotic and anticancer natural products from cryptic biosynthetic gene clusters found in soil dwelling
bacteria.
- Training Groups
- Prospective Faculty
- Biomolecular Structure and Biophysics
- Biotechnology
- Chromatin and Regulation of Gene Expression
- Chemical Biology
- Computational and Systems Biology
- Integrative Neuroscience
- Membrane Biology
- Microbiology, Immunology and Infectious Diseases
- Molecular Signaling and Cancer Biology
- Plant Biology
