Molecular Signaling and Cancer Biology

Research includes:

  • Metastasis
  • Immunotherapy
  • microRNAs
  • Metabolism
  • Systemic tumor dormancy
  • Growth factor signaling
  • 3D culture systems
  • Apoptosis
  • Cell cycle
  • Cell differentiation
  • Epigenetics
  • Transcription factors

Training Group Mission:

Mission: To train the next generation of leaders in cancer research, and develop new knowledge that will translate into improved outcomes for cancer patients. Our cancer biology training program combines rigorous training basic biomedical sciences with translational research experiences in relation to human cancer. The program is in strong affiliation with the Purdue Center for Cancer Research (PCCR). We have been a National Cancer Institute-designated center for over 40 years. The PCCR and the Cancer Biology training program include research labs from numerous departments across campus all focused on graduate education in cancer research. A major goal of our program is to encourage and facilitate the development of integrated, interdisciplinary approaches by promoting collaborations within our training group and with other research areas such as pharmacology, biomedical engineering, and chemical biology.

Faculty Membership

Research Area

Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation

The role of protein phosphatases in regulating cellular plasticity and therapeutic resistance in cancer

Epigenetic mechanisms in liver cancer pathogenesis due to chronic infection with the Hepatitis B Virus.

Obesity is associated with an increased risk of and/or mortality from several forms of cancer, including breast and colon cancer. Given that obesity rates in the U.S. are now approaching 40%, the development of mechanism-based interventions for this population could have a significant impact on public health. My research program focuses on investigating the molecular mechanisms linking obesity with increased breast and colon cancer risk and progression, with the goal of developing dietary and pharmaceutical interventions that reduce risk and improve prognoses in the obese patient population.

Role of histone methylation in gene expression and oncogenesis
Cell and developmental biology, membrane trafficking, molecular genetics, cell polarity
Structure and function of large protein complexes; Cryo-electron microscopy.

Chemical Immunology: Cell specific chemical perturbation of immune microenvironments in cancer, neurological and immunological disorders

We work on understanding and targeting epigenetic regulators in cancer initiation, progression, and chemotherapy resistance.

Our laboratory develops strategies that can leverage the immune system to simultaneously repair bone and control inflammation or cell viability. The overall
therapy goals are to (a) treat tumors and repair bone in tumor models and (b) treat and repair cartilage/bone in arthritis models.

Regulation of mineral metabolism, molecular actions of vitamin D in calcium metabolism and cancer prevention, gene-environment interactions influencing bone/calcium metabolism or cancer
Environmental and molecular toxicology, genomics, and cytogenetics
Macromolecular sequences and the evolution, structure and function of molecules; databases and computational tools for functional genomics

The Hall lab is generally interested in mechanisms cell cycle control that protect genome stability. Our work provides insight into how normal cells maintain genome fidelity during the complex process of cell division and how defects in the regulation of cell division can lead to various forms of genome instability and disease, including cancer.

We study the initiation, progression, and metastasis of vascular sarcomas with a focus on the role of microRNAs.
Functional genomics and systems biology
Multidrug resistance in human cancer
The Chang-Deng Hu lab in the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University has developed an integrated research program that involves technology development, biological discovery and clinical translation. The current research interest is mainly focused on mechanism and targeting of therapy-induced neuroendocrine differentiation in prostate cancer, lung cancer and pancreatic cancer. The lab is using cutting edge technologies and multidisciplinary approaches to discovering and validating novel therapeutic targets and developing novel therapeutics for cancer treatment.
Biological roles of miRNAs and their use as cancer therapeutics
Dietary Control of Adipose Development and Its Function
Epigenetics, Impacts of Chromatin on Gene Expression, DNA Replication & DNA Repair
Gene expression during mammalian development; cancer model systems
bio-organic chemistry, bioconjugate chemistry, in vitro evolution, drug discovery
Stem cell biology; Muscle development and regeneration; Signaling regulation of satellite cells; Adipose stem cell; muscle-fat interaction
Understanding how the cell nucleus directs expression and stability of the genome and how tissue architecture influences nuclear organization; development of 3D cell culture and organ-on-a-chip models for discovery of targets and cell nucleus-based readouts in cancer prevention and treatment;

Immunotherapy, A regulatory mechanism of anti-tumor immunity, A resistance mechanism of target therapy and/or immunotherapy, Antibody engineering

Roles of Polo-like kinase 1 and its interacting proteins in cell proliferation and carcinogenesis

Understanding the regulation of phospholipase C enzymes in cardiovascular disease and cancer through macromolecular structure determination and functional assays.

Biochemistry, Signal Transduction, Microbiology
MDM2, p53, cerebellar development and tumorigenesis, mouse models of human disease

In the Parkinson lab, we focus on the discovery of novel antibiotic and anticancer natural products from cryptic biosynthetic gene clusters found in soil dwelling

Computational chemistry and biological NMR
Microbial pathogenesis; host-parasite interactions; molecular detection and differentiation of microbial pathogens; recombinant and DNA vaccines
NeuroEngineering / Cellular Neurobiology
Signal transduction and protein Ser/Thr phosphatases
Ecology of natural systems, ecotoxicology, animal health
Drug Discovery in Cancer and Alzheimer's Disease Using Chemical Biology Tools
Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function
Cell signaling and morphogenesis in the leaf epidermis
Proteomics and biological mass spectrometry
Oncogene expression in eukaryotic cells
Vitamin D and cancer Vitamin D and calcium regulation of body composition
We primarily study the molecular basis of GPCR-mediated signal transduction, principally via the techniques of X-ray crystallography and single particle electron microscopy. By determining atomic structures of signaling proteins alone and in complex with their various targets, we can provide important insights into the molecular basis of signal transduction and how diseases result from dysfunctional regulation. The lab is also interested in rational drug design and the development of biotherapeutic enzymes.
Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation
Signal transduction in development; mechanisms of robustness, cell fate decisions, and tissue patterning by morphogen gradients
We study metastatic breast cancer with a focus on the tumor microenvironment and development of antimetastatic therapeutics.
Signal transduction in cancer biology, early neuronal development and cancer metabolism.
Phytohormone ethylene biosynthesis and its signaling pathway in Arabidopsis thaliana
Cancer biology; Zebrafish cancer Model; Comparative oncogenomics; Evolutionary developmental biology (Evo-Devo)
Protein tyrosine phosphatases (PTPs), structure and function, PTP-mediated cellular signaling mechanisms, roles of PTPs in normal physiology and diseases, chemical biology and drug discovery

Ernest C. Young Hall, Room 170 | 155  S. Grant Street, West Lafayette, IN 47907-2114 | 765-494-2600

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