Plant host-viral interactions; identification, characterization of molecular markers for resistance genes; cellular and functional genomics
Mechanism(s) of liver cancer pathogenesis by the Hepatitis B Virus X protein. Signal transduction networks in neuronal development and cancer pathogenesis.
Transcriptional regulation in poxviruses
Development of small molecules, peptides and peptidomimetics for drug discovery, bionanotechnology, and cellular delivery of therapeutic agents
Interactome based drug discovery: Computational and analytical chemistry techniques to design and verify small molecules drugs and "cells as drugs" for cancer, neurological and immunological disorders.
Design and synthesis of molecules that interact with enzymes and membrane-bound receptors
Leukocytes response to infection, discovery of agents to suppress inflamation
Parasitology, Immunology, Cellular Trafficking, Vaccine Development
Use of chemistry as a tool to elucidate biological mechanisms
Structural cell biology of infection, immunity, and aging
Mechanism of the transfer to and expression of the Agrobacterium tumefaciens Ti-plasmid in plant cells
Structural basis for RNA function
Molecular biology of arthropod vectors of disease, with an emphasis on vector-pathogen interactions, characterization of arthropod G protein-coupled receptors, and insecticide discovery.
Structure of tailed dsDNA bacteriophages and Flaviviruses; Membrane protein structure by 2-D crystallization; Cryo-EM method development; Large scale computing for cryo-EM image processing
veterinary pathology, molecular pathology, immunopathology, mouse models of human disease, inflammatory bowel disease, microbiome, colon cancer, dengue virus
Immune cell development, trafficking and effector function
Epigenetic processes that mediate heritable modifications to chromatin
Viral gene expression; virus-host interactions; pathogenesis; virus receptors and virus assembly
Systems biology of host-pathogen interactions; dengue virus; malaria parasites; protein-protein interactions
Virus study using electron microscope tomography
Diagnostic pathology, molecular pathology, and immunohistopathology of infectious, toxic, and neoplastic diseases
Molecular Virology - function of viral genes in virus replication, disease development, and virus control
Development of targeted therapic and imaging agents for cancer and various inflammatory diseases. Function and molecular organization of the human red blood cell membrane. Novel methods for detection of human pathogens.
Type IV protein secretion of Legionella pneumophila; intracellular multiplication and trafficking of bacterial pathogens
Biochemistry, Signal Transduction, Microbiology
Molecular Genetics of Plant Immunity - with emphasis on host defense response to necrotrophic fungi
Gene-to-Lead Drug Discovery
Computational chemistry and biological NMR
Microbial pathogenesis; host-parasite interactions; molecular detection and differentiation of microbial pathogens; recombinant and DNA vaccines
Structure of picornaviruses, parvoviruses, alphaviruses and bacteriophages, fX174, f29, T4; molecular evolution
Entry of retroviruses and other enveloped viruses into cells; mechanism of enzymatic phosphoryl transfer
Oncogene expression in eukaryotic cells
Organic synthesis, nanostructured materials science, self-assembly principles to produce exotic materials with physical or biomimetic function
Cancer metastasis and development of resistance to targeted molecular therapies.
Salmonella typhimurium Type III secretion; actin cytoskeleton rearrangements and bacteria-host interactions