Chromatin and Regulation of Gene Expression

Research includes:

  • Biochemistry
  • Chromatin
  • DNA Repair
  • Gene Expression
  • Genomics
  • Nucleic Acids
  • Transcription

Training Group Mission:

Students in this training group work with a diverse group of faculty who employ an extensive range of experimental approaches with the goal of understanding chromatin and regulation of eukaryotic gene expression. Recent advances in the identification of chromatin modifying proteins and in the elaboration of the “histone code hypothesis” illustrate the value of interdisciplinary approaches in gaining insights into this exciting area of research. Students also have the opportunity to examine the effect of chromatin on other DNA-based processes such as replication, recombination, and repair. All students receive broad training in genetic, biochemical, and genome-based approaches in analysis of these fundamental processes.


Faculty Membership

Faculty
Research Area

Control of eukaryotic gene expression and replication; DNA structure; virus evolution

Role of histone methylation in gene expression and oncogenesis
Transcriptional regulation in poxviruses

Our research focuses on understanding critical epigenetic mechanisms involved in the regulation of the stem cell plasticity and the stem cell fate in breast cancer, and translating the promising basic research findings into innovative clinical applications, aiming to impact the diagnosis, treatment and prevention of breast cancer.

Structure and function of large protein complexes; Cryo-electron microscopy.
The genetic basis of reproductive barriers and molecular mechanisms of plant adaptation. Cost effective integration of genomics for comparative and forward genetics research approaches.
Nutritional Biochemistry and Physiology
We work on understanding and targeting epigenetic regulators in cancer initiation, progression, and chemotherapy resistance.
Genetic and genomic investigation of naturally-occurring canine diseases and traits
Regulation of mineral metabolism, molecular actions of vitamin D in calcium metabolism and cancer prevention, gene-environment interactions influencing bone/calcium metabolism or cancer
Mechanism of the transfer to and expression of the Agrobacterium tumefaciens Ti-plasmid in plant cells
Regulation of DNA methylation in development and disease
Molecular biology, cell biology, cancer biology and molecular imaging
DNA microarray technology to investigate the genomic basis of disease, development, and drug toxicity
Biological roles of miRNAs and their use as cancer therapeutics
Epigenetic processes that mediate heritable modifications to chromatin
Gene expression during mammalian development; cancer model systems
Understanding how the cell nucleus directs expression and stability of the genome and how tissue architecture influences nuclear organization; development of 3D cell culture and organ-on-a-chip models for discovery of targets and cell nucleus-based readouts in cancer prevention and treatment;
Epigenetic regulation of transposable elements
Functional genomics; Epigenomics; Histone modification; Environmental responses; Systems Biology; Plant Genetics
Regulation of cell identity, signal transduction, chromatin remodeling
Nutritional Epigenetics, Cancer Epigenetics. Epigenetic mechanisms of vitamins and polyphenols in cancer prevention and therapy. Epigenetic biomarkers for solid tumors.
Oncogene expression in eukaryotic cells
Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation

Aging photoreceptors in the eye show characteristic changes in gene expression. Our lab is interested in understanding the mechanisms that drive these changes in gene expression. These studies provide a model for understanding how aging contributes to ocular diseases such as age-related macular degeneration. Our work is funded by the National Eye Institute of the NIH. We are actively seeking new graduate students, so please contact us if you are interested in joining our group.

Maize genetics, genomics, value-added traits
Signal transduction in cancer biology, early neuronal development and cancer metabolism.

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